Megagam Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 25 Nov 2025 | 03:07 PM (IST)

Megagam Tablet is a combination medicine used for the treatment of neuropathic pain. This medicine decreases pain by modulating calcium channel activity of the nerve cells.

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Gabanyl 300mg/500mcg Tablet

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Megagam Tablet

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Gabanyl 300mg/500mcg Tablet

strip of 10 tablets

Gabapentin (300mg) + Methylcobalamin (500mcg)

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General Information

Contains

Gabapentin (300mg)+ Methylcobalamin (500mcg)

Marketer

Origam Pharmocrats

Storage

Store below 30°C

The content is shown in English

Product introduction

Megagam Tablet is taken by mouth with or without food, preferably at bedtime. It is advised to take medicine at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by your doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor.

Some common side effects of this medicine are nausea, peripheral edema, ataxia, blurred vision, fever and nystagmus (involuntary eye movement). It may also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. It is important to inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Before taking the medicine you should tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It can usually be mixed safely with other medicines but some drugs (including antacids and alcohol) do affect the way it works and can increase the chance of side effects.

Uses of Megagam Tablet

Treatment of Neuropathic pain

Benefits of Megagam Tablet

Treatment of Neuropathic pain
Megagam Tablet is a combination of medicines used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes, shingles or spinal cord injury. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It is thought to work by interfering with pain signals that travel through the damaged nerves and the brain. Using this medicine regularly will improve your physical and social functioning and overall quality of life. It takes a few weeks to work so you need to use it regularly even if you feel it is not doing any good. Once your symptoms have gone you should still keep using the medicine until your doctor advises you to stop.

Side effects of Megagam Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Megagam

Dizziness
Sleepiness
Tiredness

How to use Megagam Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Megagam Tablet may be taken with or without food.

How Megagam Tablet works

Megagam Tablet is a combination of two medicines: Gabapentin and Methylcobalamin. Gabapentin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

All substitutes for Megagam Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed Megagam Tablet for treating and preventing nerve pain.
Its side effects are usually mild and temporary.
It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
To lower the chances of feeling dizzy or passing out, rise slowly if you have been sitting or lying down.
Avoid consuming alcohol when taking Megagam Tablet, as it may cause excessive sleepiness.
Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression or suicidal thoughts or behavior.
Do not stop taking the medication suddenly without talking to your doctor.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Megagam Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Megagam Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Megagam Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

UNSAFE

Megagam Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.

Kidney

CAUTION

Megagam Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Megagam Tablet in patients with liver disease.

Frequently asked questions

What is Megagam Tablet?

Megagam Tablet is a combination of two medicines: Gabapentin and Methylcobalamin. This medication is useful in the treatment of pain due to nerve damage (peripheral neuropathy). This medication works by regenerating damaged nerves in the body and decreasing the pain sensation.

What is peripheral neuropathy?

The nerves in the periphery of your body, such as the nerves in your toes and fingertip are called peripheral nerves and any damage to one or more of these nerves is called peripheral neuropathy. These nerves carry messages to/from the brain and spinal cord from/to the rest of the body. A damage caused to these nerves stops them from functioning properly and the messages traveling between your central and peripheral nervous system get disrupted.

Can I stop taking Megagam Tablet when my pain is relieved?

No, take Megagam Tablet for the full prescribed length of time. Your symptoms may improve before the nerves are completely regenerated and healed.

Can the use of Megagam Tablet cause sleepiness?

Yes, the most common side effect of Megagam Tablet is sleepiness. Do not drive, operate heavy machinery or engage in other activities that need your full attention. Do not drink alcohol while taking Megagam Tablet as it can lead to severe sleepiness , causing falls or accidents.

Can I take a higher than the recommended dose of this medicine?

No, taking a higher than the recommended dose of Megagam Tablet can lead to increased chances of side effects and toxicity. If you are experiencing increased severity of your symptoms that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

What is the recommended storage condition for the Megagam Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

Stahl SM, editor. Gabapentin. In: Stahl's Essential Pschopharmacology: Prescriber's Guide. 5th ed. New York, New York: Cambridge University Press; 2014. pp. 275-77.
McNamara JO. Pharmacotherapy of the Epilepsies. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. p. 599.
Porters RJ, Meldrum BS. Antiseizure Drugs. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 410.
Combs Jr. GF, McClung JP. The Vitamins: Fundamental Aspects in Nutrition and Health. 5th ed. Westborough, MA: Academic Press; 2017.
PubChem. Methylcobalamin hydrate. [Accessed 22 Apr. 2019] (online) Available from:
Arlak Biotech. Methylcobalamin+gabapentin [Product Information]. [Accessed 14 Aug. 2024] (online) Available from:

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Origam Pharmocrats
Address: AO.Kalpatru, AV.6, RT Street,20th Cross, BVK Iyenger Road ,Bengaluru 560053, Karnataka, India

Vendor Details

Country of origin: India

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Why we need a prescription?

Provide right medicines

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In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Megagam Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Megagam Tablet

Benefits of Megagam Tablet

Side effects of Megagam Tablet

How to use Megagam Tablet

How Megagam Tablet works

All substitutes for Megagam Tablet

Gabanyl-M Tablet

Gabanyl 300mg/500mcg Tablet

Nurokind-G Tablet

GABAntin Forte Tablet

pentanerv M 300mg/500mcg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Megagam Tablet?

What is peripheral neuropathy?

Can I stop taking Megagam Tablet when my pain is relieved?

Can the use of Megagam Tablet cause sleepiness?

Can I take a higher than the recommended dose of this medicine?

What is the recommended storage condition for the Megagam Tablet?

Fact Box

Habit Forming

Therapeutic Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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