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Mefip-Plus Tablet is a combination of two medicines used in the treatment of fever. It is also useful for the treatment of mild to moderate pain of various conditions like headache, body ache, and toothache. It works by reducing chemical messengers that cause pain, inflammation, and fever.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 22 May 2026 | 06:22 PM (IST)
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Your child’s medicine at a glance

Mefip-Plus Tablet is to be taken with food. This will prevent you from getting an upset stomach. The dose will depend on what you are taking it for and how well it helps your symptoms. You should take it as advised by your doctor. Do not take more or use it for a longer duration than recommended by the doctor.

The most common side effects of this medicine include nausea, vomiting, diarrhea, indigestion, loss of appetite, and heartburn. If any of these side effects bother you or get worse, you should speak to your doctor. Your doctor may be able to suggest ways of preventing or reducing the side effects.

Before taking it, you should let your doctor know if you have a history of ulcers or bleeding in your stomach, high blood pressure, or any trouble with your heart, kidneys, or liver. Let your doctor also know about all the other medicines you are taking because they may affect, or be affected by, this medicine.

Uses of Mefip-Plus Tablet in children

  • Pain relief : Mefip-Plus Tablet helps relieve pain in conditions such as headache, body ache, muscle pain, toothache, menstrual cramps, and minor injuries.
  • Treatment of Fever : Mefip-Plus Tablet helps reduce fever in conditions such as flu, viral infections, post-vaccination reactions, and other illnesses associated with fever.

Benefits of Mefip-Plus Tablet for your child

Pain relief
Pain can occur due to inflammation or injury affecting different parts of the body. Mefip-Plus Tablet works by blocking chemical messengers responsible for pain and inflammation. This helps reduce discomfort in conditions such as headache, toothache, muscle pain, joint pain, and menstrual cramps. It improves daily functioning and provides effective short-term relief from pain.
Treatment of Fever
Fever is usually a sign of infection or inflammation in the body. Mefip-Plus Tablet helps reduce high temperature by blocking chemical messengers that trigger fever. This brings down body temperature and relieves associated symptoms such as body aches and discomfort.

Side effects of Mefip-Plus Tablet in children

Mefip-Plus Tablet does not pose serious side effects and is well-tolerated by children. In case the side effects do occur, they’re likely to subside once the body adapts to the medicine. Consult your child’s doctor if these side effects persist or bother your child. The most common side effects include-
Common side effects of Mefip-Plus
  • Vomiting
  • Diarrhea
  • Nausea
  • Indigestion
  • Loss of appetite
  • Heartburn

How can I give Mefip-Plus Tablet to my child?

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mefip-Plus Tablet should be taken with or after food.

How Mefip-Plus Tablet works

Mefip-Plus Tablet is a combination of two medicines: Mefenamic Acid and Paracetamol. It works by blocking the release of certain chemical messengers that cause fever, pain and inflammation (redness and swelling).

Quick tips

  • Take Mefip-Plus Tablet with food to reduce the risk of stomach irritation.
  • Avoid taking Mefip-Plus Tablet with other medicines containing paracetamol or other NSAIDs unless advised by your doctor.
  • Mefip-Plus Tablet may cause dizziness or sleepiness, so avoid driving or operating machinery until you know how it affects you.
  • Stop taking Mefip-Plus Tablet and consult your doctor if you develop diarrhea while using this medicine.
  • Watch for warning signs such as severe stomach pain or black/tarry stools, and seek medical attention if they occur.
  • Avoid alcohol while taking Mefip-Plus Tablet as it may increase drowsiness and the risk of stomach or liver problems.
  • Stay well hydrated while taking Mefip-Plus Tablet, as dehydration may increase the risk of kidney-related side effects.
  • Inform your doctor if you develop rash, swelling, or other signs of allergy while taking Mefip-Plus Tablet.
  • Do not use Mefip-Plus Tablet for long periods without medical supervision.
  • Your doctor may monitor kidney function, liver function, and blood parameters if Mefip-Plus Tablet is used for long-term treatment.
  • Inform your doctor if you have a history of kidney disease, liver disease, or stomach ulcers before taking Mefip-Plus Tablet.
  • Do not increase the dose or frequency of Mefip-Plus Tablet without medical advice.
  • Consult your doctor if pain or fever persists or keeps recurring despite taking Mefip-Plus Tablet.

Safety advice

Kidney

Kidney

CAUTION
Mefip-Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of Mefip-Plus Tablet is not recommended in patients with severe kidney disease.
Liver

Liver

UNSAFE
Mefip-Plus Tablet is unsafe to use in patients with liver disease and should be avoided.
However, the use of Mefip-Plus Tablet is not recommended in patients with severe liver disease and active liver disease.

Frequently asked questions

Mefip-Plus Tablet may cause some common side effects such as nausea, stomach pain, heartburn, or diarrhea. Some people may also experience vomiting or dizziness. These effects often occur because the medicine can irritate the stomach lining. Taking Mefip-Plus Tablet with food or milk may help reduce stomach discomfort. In rare cases, it may cause serious problems such as stomach bleeding or kidney damage. Seek medical attention if you notice warning signs such as black stools, vomiting blood, or severe stomach pain.
Mefip-Plus Tablet is usually prescribed for short-term use to relieve pain. In many cases, it can be stopped once the pain improves. However, if your doctor has advised you to take it for a specific period, you should continue using it for the recommended duration. Always follow your doctor’s instructions before stopping any prescribed medicine.
Mefip-Plus Tablet should be avoided by people who are allergic to this medicine or to other similar pain relievers known as NSAIDs. It is also not recommended for individuals with stomach ulcers, active stomach bleeding, severe liver disease, or serious kidney problems. People who have a history of stomach irritation or bleeding should only take it if advised by a doctor. Always inform your doctor about your medical history and any other medicines you are taking before starting Mefip-Plus Tablet.
Yes, Mefip-Plus Tablet can usually be taken with vitamin B-complex supplements. While Mefip-Plus Tablet helps relieve pain, vitamin B-complex may help correct vitamin deficiencies that could contribute to certain types of pain, such as nerve-related discomfort. However, it is still best to consult your doctor before combining medications or supplements.
Mefip-Plus Tablet may affect the kidneys or liver if it is used for a long time or taken in higher-than-recommended doses. The medicine can reduce protective substances that help maintain kidney function, which may lead to kidney damage. Misuse or combining it with other medicines containing similar ingredients may also strain the liver. The risk is higher in people who already have kidney or liver disease. Always take Mefip-Plus Tablet only as prescribed and avoid unnecessary or prolonged use.
Mefip-Plus Tablet is a medicine used for short-term relief of pain and fever. It is commonly prescribed for menstrual cramps (period pain), dental pain, headaches, muscle or joint pain, and general body aches. It works by reducing certain substances in the body that cause pain, inflammation, and fever. While it helps relieve symptoms, it does not treat the underlying cause of the pain. Always take Mefip-Plus Tablet exactly as directed by your doctor and avoid long-term or unnecessary use.
Mefip-Plus Tablet is generally not recommended during pregnancy unless your doctor specifically advises it. Anti-inflammatory pain medicines can affect pregnancy and the baby, especially during the later stages. Mefenamic acid may affect the baby’s circulation and kidney function later in pregnancy and may also increase bleeding risk. If you are pregnant, think you may be pregnant, or are planning pregnancy, consult your doctor before taking Mefip-Plus Tablet.
It is best to avoid alcohol while taking Mefip-Plus Tablet. Alcohol can increase the risk of stomach irritation and bleeding, and it may also add stress to the liver when combined with certain pain medicines. If you drink alcohol regularly, discuss this with your doctor before taking Mefip-Plus Tablet.
The active ingredient in Mefip-Plus Tablet, mefenamic acid, is gradually cleared from the body, although the exact time can vary depending on factors such as age, liver and kidney function, and hydration. Even after the medicine starts leaving the body, stomach irritation or bleeding risk may persist for some time. If you are planning surgery or have kidney problems, inform your doctor that you have taken Mefip-Plus Tablet so they can advise you appropriately.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Apotek Pharma Private Limited
Address: Velutha Thodika House Kallarattikkal Urangattiri Malappuram KL 673639 India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Mefip-Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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