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Composition for LOTEGATE

Gatifloxacin(0.3% w/v),Loteprednol(0.5% w/v)

food interaction for LOTEGATE

alcohol interaction for LOTEGATE

pregnancy interaction for LOTEGATE

lactation interaction for LOTEGATE

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Lotegate eye drop may be unsafe to use during pregnancy.
Either animal studies have shown adverse effect on fetus and there are no human studies or studies in human and animals are not available. It should be given only if potential benefits justifies risk to the fetus. Please consult your doctor.
Lotegate eye drop is probably safe to use during breastfeeding. Please consult your doctor.


Gatifloxacin(0.3% w/v)


Gatifloxacin is used as a local treatment for bacterial eye infection (conjunctivitis) in adults and children older than 1 year of age.

How it works

Gatifloxacin is an antibiotic belongs to the group of medicines called fluoroquinolone antibiotics. It inhibits bacterial reproduction by inhibiting protein formation, thereby killing the bacteria.

Common side effects

Rash, Blurred vision, Broken blood vessels in the eyes, Dry eye, Difficulty in swalloing, Shortness of breath, Eye discharge, Eye pain, Facial swelling, Headache, Irritation, Itching, Teary eyes, Urticaria, Voice alteration
Loteprednol(0.5% w/v)


Loteprednol is used in the treatment of inflammatory and allergic conditions of the superficial layers of the eye, such as allergic conjunctivitis (allergic itching and redness of the whites of the eye, with tearing), conjunctivitis that occurs as part of acne rosacea (persistent redness over the areas of the face and nose), superficial punctate keratitis (inflammation of cornea), iritis (Inflammation of the interior eye structures), cyclitis (inflammation of cilliary body of the eye). It is also used in the treatment of postoperative inflammation of the eye after the eye surgery.

How it works

Loteprednol belongs to a class of medication called as ophthalmic corticosteroid. The exact mechanism of action is not known. They are thought to induce certain proteins (phospholipase A 2 inhibitory proteins) which inhibit the formation of other compounds like prostaglandin and leukotrienes which promote inflammation. As a result, the redness, swelling, and itching is relieved at the site of administration.

Common side effects

Burning sensation, Conjunctival redness, Conjuntival disorder, Corneal damage, Dry eye, Eye discharge, Eye irritation, Foreign body sensation in eyes, Headache, Increased production of tears, Itching


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Expert advice for LOTEGATE

  • Use eye drops as recommended in the information leaflet or as prescribed by your doctor.
  • Do not wear contact lenses, if you have bacterial conjunctivitis or you are applying eye drops.
  • Do not drive or operate machinery as you may have blurred vision after using the medicine.
  • Doctor’s advice should be considered in case of patients with following history of disease conditions:  loss of memory and mental ability (Alzheimer disease), inflammation of a part of tendon that attach muscles to the bone (tendonitis), fits (seizures), or any other central nervous system problems, or increased pressure in the head; low blood potassium levels, diabetes, kidney, liver or heart problems.
  • If long-term or repeated use of gatifloxacin drops may cause a second infection.
  • Do not take gatifloxacin, if you are pregnant or planning to become pregnant or breastfeeding.
  • Avoid using gatifloxacin, if you take coffee or other beverages containing caffeine during treatment.

Frequently asked questions for LOTEGATE


Q. Does gatifloxacin contain sulfa?
Gatifloxacin does not contain sulfa. It is a fluoroquinolone antibiotic.
Q. Is gatifloxacin the same as Zymaxid?
Zymaxid is the brand name for gatifloxacin eye solution.
Q. Is gatifloxacin the same as ofloxacin?
Both gatifloxacin and ofloxacin belongs to the different class, i.e. gatifloxacin is second-generation fluoroquinolone whereas ofloxacin is older and first-generation, but their effect may vary upon individual condition or response.
Q. What does gatifloxacin treat?
Gatifloxacin treats bacterial eye infection (conjunctivitis or red eye) in adults and children older than 1 year of age.
Q. Is gatifloxacin banned in India?
Gatifloxacin is banned in India for systemic use in human by any route including oral and injectable. Its use as eye drop is not banned.


Q. What is loteprednol/loteprednol etabonate?
Loteprednol is a corticosteroid available as an eye drop that reduces inflammation of superficial structures of the eye.


Content on this page was last updated on 17 March, 2014, by Dr. Varun Gupta (MD Pharmacology)