Overview
Uses and benefits
How to use
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
User feedback
FAQs

Author Details

Written By

Dr. Anuj Saini

MMST, MBBS

Reviewed By

Dr. Mekhala Chandra

MD, MBBS

Last updated

09 Jun 2025 | 10:24 AM (IST)

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Leucorin Tablet

Prescription Required

NPPA Regulated

Marketer

Samarth Life Sciences Pvt Ltd

SALT COMPOSITION

Calcium Leucovorin (15mg)

Salt Synonyms

Calcium folinate

Storage

Store below 30°C

Click here to view all substitutes

Product introduction

Leucorin Tablet is used to prevent the harmful effects of methotrexate (anticancer medicine). It is also used in the treatment of methotrexate overdose.

Leucorin Tablet can be taken with or without food. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects.

It is generally safe medicine to use with no common side effects if taken in the right amount. Your doctor may request regular blood tests to monitor your blood cells and serum methotrexate concentration in the blood.

Before taking it, tell your doctor if have seizures, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using, especially phenytoin for your seizures.

Uses of Leucorin Tablet

Benefits of Leucorin Tablet

In Prevention of Harmful effects of methotrexate

Leucorin Tablet helps protect the body cells against the harmful effects of methotrexate, an anti-cancer medicine. It is a form of vitamin B that is given after 24 hours of methotrexate administration. This makes sure that methotrexate has achieved its anti-cancer effects and also, Leucorin Tablet will prevent the other side effects such as anemia.

How to use Leucorin Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Leucorin Tablet may be taken with or without food, but it is better to take it at a fixed time.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Leucorin Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

Leucorin Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Leucorin Tablet during breastfeeding is not available. Please consult your doctor.

Driving

SAFE

Leucorin Tablet does not usually affect your ability to drive.

Kidney

CONSULT YOUR DOCTOR

There is limited information available on the use of Leucorin Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited information available on the use of Leucorin Tablet in patients with liver disease. Please consult your doctor.

What if you forget to take Leucorin Tablet?

If you miss a dose of Leucorin Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Leucorin Tablet

₹45.7/Tablet

Unifolin 15mg Tablet

United Biotech Pvt Ltd

₹42.8/tablet

6% cheaper

Zovorin 15mg Tablet

Zuvius Life Sciences

₹39.4/tablet

14% cheaper

Neovorin 15mg Tablet

Neon Laboratories Ltd

₹18.8/tablet

59% cheaper

Leevarin 15 Tablet

Admac Pharma Ltd

₹47.9/tablet

5% costlier

Quick tips

You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.
You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.
You have been prescribed Leucorin Tablet to reduce the side effects of the medicine methotrexate.
Take it 24 hours after taking methotrexate. If taken at the same time, it may counteract the effect of methotrexate.
Inform your doctor if you are also taking certain medications such as phenytoin for your seizures as Leucorin Tablet may counteract the antiepileptic effects.

Fact Box

Chemical Class

Glutamic acid Derivatives

Habit Forming

Therapeutic Class

BLOOD RELATED

Action Class

Folic Acid Analogs

Patient concerns

Common cold with bronchitis fever two days Fever with common cold & bronchitis

Dr. Gopal Bansilal Samdani

Paediatrics

There are many underlying causes of your symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Final and perfect diagnosis cannot be done without doing clinical examination of child. Please consult me or any other Paediatrician. will take detail history and will examine your child in detail. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. At time may ask you relevant investigations if necessary. Your child may need antibiotics and/or other prescription drugs.

Common cold and fever, headache, body ache,

Dr. Vijay Verma

ENT

Take tab lcz plus at bedtime for two days and tab paracetamol 500mg three times a day for two days in case no improvement in two days visit ent specialist near you for proper examination

Suffering from fever, cough and cold headache and boadache

Dr. Gopal Bansilal Samdani

Paediatrics

Monitor temperature of Patient. If Patient has fever place a cool, damp washcloth on your child's forehead. Give your Patient a lukewarm tub bath or a sponge bath. Give a sponge bath as follows: - ? Use lukewarm water [90?F (32.2?C) to 95?F (35?C)]. Do not use cold water, ice, or rubbing alcohol, which will lower the child's body temperature too quickly. ? Sponge for 20 to 30 minutes. ? Stop if the child starts to shiver. If your child doesn't like the sponge bath or doesn't feel better after the bath, there is no need to give another one. You can use paracetamol also along with above measures to control fever till you consult Dr. will determine underlying disorders by clinical examination which range from mild conditions to the most serious of bacterial and viral illnesses and will prescribe medicines accordingly. Advice given without doing clinical examination can be imperfect or some time harmful to patient.

User feedback

Patients taking Leucorin Tablet

Once A Day

49%

Once A Week

37%

Twice A Day

Alternate Day

Thrice A Day

Thrice A week

Twice A Week

What are you using Leucorin Tablet for?

Others

100%

How much was the improvement?

Excellent

83%

Average

17%

How do you take Leucorin Tablet?

With food

100%

Please rate Leucorin Tablet on price

Expensive

67%

Average

33%

FAQs

What is Leucorin Tablet used for?

Leucorin Tablet is used to prevent harmful effects of methotrexate (a cancer chemotherapy medication) when methotrexate is used to treat certain types of cancer. Leucorin Tablet is also used to treat people who have accidentally received an overdose of methotrexate or similar medications. It is also used for the treatment of megaloblastic anemia due to folic acid deficiency and when oral therapy is not feasible.

What is megaloblastic anemia?

Anemia is a blood disorder in which the number of red blood cells (RBCs) that carry oxygen is lower than usual. As a result, your tissues and organs don’t get enough oxygen. Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells. Usually, megaloblastic anemia is due to vitamin B12 or folic acid deficiency.

How long does it take for Leucorin Tablet to work?

Leucorin Tablet starts acting on the body within 20-30 minutes of oral intake. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

What are some of the laboratory tests conducted before or during the treatment with Leucorin Tablet?

Your doctor will prescribe blood tests to check your levels of serum methotrexate concentration (in case of methotrexate chemotherapy or overdose) to determine the optimal dose and duration of treatment with Leucorin Tablet. You will also be prescribed a complete blood count to monitor the number of red blood cells (in case of megaloblastic anemia). Along with this, your calcium levels will also be monitored in order to prevent hypercalcemia (excess calcium) since Leucorin Tablet contains calcium.

What measures should be taken to ensure the prompt excretion of methotrexate during treatment with Leucorin Tablet?

Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Calcium Folinate. Hurley, Maidenhead: Hospira UK Limited; 1985 [revised Jan. 2018]. [Accessed 26 Mar. 2019] (online) Available from:
DailyMed. Leucovorin calcium. [Accessed 26 Mar. 2019] (online) Available from:

Marketer details

Name: Samarth Life Sciences Pvt Ltd

Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Country of origin: India
Expires on or after: October, 2026

A licensed vendor partner from your nearest location will deliver Leucorin Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India