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MRP: Rs. 52 for 1 strip(s) (3 tablets each)
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Composition for LARI

Pyrimethamine(25 mg),Sulfamethoxazole(500 mg)

food interaction for LARI

alcohol interaction for LARI

pregnancy interaction for LARI

lactation interaction for LARI

There is no data available. Please consult doctor before consuming the drug.
Interaction with alcohol is unknown. Please consult your doctor.
Lari 25 mg/500 mg tablet is unsafe to use during pregnancy.
There is positive evidence of human fetal risk, but the benefits from use in pregnant women may be acceptable despite the risk, for example in life-threatening situations. Please consult your doctor.
Unknown. Human and animal studies are not available. Please consult your doctor.


Pyrimethamine(25 mg)


Pyrimethamine along with other antibiotic sulphonamides is used to treat toxoplasmosis, an infection caused by the Toxoplasma parasite. It is also used to treat or prevent malaria infections along with other medicine.

How it works

Pyrimethamine belongs to a group of medicines called antiprotozoals. It is an antiparasitic and works by killing the parasites or preventing their growth in the blood stream.

Common side effects

Abnormal bruising, Abnormal skin pigmentation, Anemia, Change in blood test results, Dizziness, Headache, Vomiting, Weakness, Diarrhoea, Nausea
Sulfamethoxazole(500 mg)


Sulfamethoxazole is used to treat malaria, conjunctivitis (irritation and redness in the membrane covering the eye) due to chlamydia, toxoplasmosis, and urinary tract infections.

How it works

Sulphamethoxazole belongs to class of medications called sulfonamide antibiotic. Sulphamethoxazole inhibits bacterial utilization of para-amino benzoic acid for the synthesis of folic acid, an important metabolite in bacterial DNA synthesis, thereby stopping bacterial growth.

Common side effects

Peripheral neuropathy, Liver injury, Agranulocytosis (deficiency of granulocytes in the blood), Aplastic anemia, Convulsion, Crystals in urine, Hypersensitivity reaction, Decreased sodium level in blood, Loss of appetite, Nausea, Skin rash, Sleepiness, Urticaria, Vertigo, Vomiting


3 Substitutes
Sorted By
    (2 tablets in strip)
    Shrinivas Gujarat Laboratories Pvt Ltd
    Rs. 3.50/tablet
    Rs. 7
    save 80% more per tablet
    (2 tablets in strip)
    Cornel Pharmaceuticals Pvt Ltd
    Rs. 9.96/tablet
    Rs. 19.93
    save 43% more per tablet
    (2 tablets in strip)
    Prayas Pharmaceuticals
    Rs. 4.37/tablet
    Rs. 8.73
    save 75% more per tablet

Expert advice for LARI

  • Pyrimethamine when given with sulphonamide, it should be given with folic acid (vitamin) supplement.
  • Do not use pyrimethamine if you are allergic to pyrimethamine or any other ingredient.
  • Do not take pyrimethamine if you have megaloblastic anemia due to folate deficiency.
  • Do not take pyrimethamine if you have kidney or liver problems; fits (seizures); depression; bone marrow problems; stomach or bowel problems (eg, malabsorption syndrome); phenylketonuria, or alcoholism.

Frequently asked questions for LARI


Q. What is pyrimethamine is used for?
Pyrimethamine is used to treat toxoplasmosis and treat or prevent malaria infections along with other medicines.
Q. How does pyrimethamine work?
Pyrimethamine is an antiparasitic and works by killing the parasites or preventing their growth in the blood stream.


Q. Is Bactrim/Septrin/septran/ ciplin, sulphamethoxazole + trimethoprin a sulfa drug, penicillin, antibiotic?
Bactrim/Septrin/septran/ciplin are brand names for sulphamethoxazole + trimethoprin combination belongs to class of medications called sulfonamide antibiotic, it is a sulpha drug. Sulphamethoxazole + trimethoprin is not a penicillin antibiotic.
Q. Is Sulphamethoxazole + trimethoprin combination safe?
Sulphamethoxazole + trimethoprin is relatively safe if used as recommended. In case of any side effects, consult your doctor.
Q. What is sulphamethoxazole + trimethoprim used for?
Sulphamethoxazole + trimethoprim is used to treat or prevent lung infections, sinus infection, toxoplasmosis, nocardiosis (bacterial infection causing abscesses), urinary tract infections, bronchitis, ear infections.

Q. Is sulphamethoxazole + trimethoprin good for tooth infection, bronchitis, upper respiratory tract infection, sore throat, strep throat, sinus infection, cough, acne, bacterial vaginosis, urinary tract infection, yeast infection, flu, kidney infection, and cover pseudomonas?
 Sulphamethoxazole + trimethoprim can be used to treat tooth infection, upper respiratory tract infection, whooping cough, acne and kidney infection. Sulphamethoxazole + trimethoprim is not the drug of choice for bacterial vaginosis, strep throat or sore throat. Sulphamethoxazole + trimethoprim is not recommended for yeast infection and flu and is resistant towards pseudomonas aeruginosa.
Q. Can I take sulphamethoxazole + trimethoprim with Tylenol/acetaminophen, Aleve/naproxen, Benadryl, prednisone, Adderall/amphetamine/dextroamphetamine, Xanax/alprazolam, Valtrex/valacyclovir, antacids, vitamins, aspirin?
Interaction is not observed, when sulphamethoxazole + trimethoprim is taken with acetaminophen, naproxen, Benadryl, prednisone, amphetamine and dextroamphetamine, alprazolam, valacyclovir, antacids, vitamins, aspirin however do consult your doctor before use.
Q. Can I take Interaction is not observed with birth control pills?
Interaction is not observed when sulphamethoxazole + trimethoprim is taken with birth control pills. Please consult your doctor before use.
Q. Does sulphamethoxazole + trimethoprim make you tired, cause headache?Sulphamethoxazole + trimethoprim can make you tired and can cause headache.


Content on this page was last updated on 13 June, 2014, by Dr. Varun Gupta (MD Pharmacology)