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Imfinzi 500mg Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 23 Mar 2026 | 11:29 AM (IST)
Imfinzi 500mg Injection is an anticancer drug used to treat several cancers, including non-small cell lung cancer, biliary tract cancer, liver cancer, and endometrial cancer. It works by blocking the PD-L1 protein on cancer cells. This allows the immune system to recognize and attack these cells more effectively.
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Stored between 2-8°C
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General Information

Contains

Durvalumab (500mg)

Marketer

AstraZeneca

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.
The content is shown in English
Imfinzi 500mg Injection image
Imfinzi 500mg Injection image

Product introduction

Imfinzi 500mg Injection is administered as an intravenous infusion, typically given in a hospital or a clinical setting. Make sure to attend all scheduled appointments and follow your doctor’s instructions. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, can help optimize the treatment's effectiveness.


Common side effects include fatigue, cough, nausea, and loss of appetite. Some patients may experience diarrhea, skin rash, or shortness of breath. If you experience severe or persistent side effects, contact your doctor immediately. Staying hydrated and reporting side effects early can help manage them effectively.


While on Imfinzi 500mg Injection, avoid activities that can increase your risk of infection, such as contact with sick individuals or large crowds. The drug can cause immune-related side effects, such as inflammation of the lungs, liver, or intestines, so report any unusual symptoms promptly.


Imfinzi 500mg Injection is not recommended for individuals with certain autoimmune conditions or those who are pregnant or breastfeeding, as it may pose risks to the fetus or infant. Before receiving this injection, inform your doctor about any other medications you are taking to avoid interactions. Always discuss your medical history and any concerns with your doctor before starting treatment.

Uses of Imfinzi Injection

Benefits of Imfinzi Injection

Treatment of Non-small cell lung cancer
Imfinzi 500mg Injection enhances overall survival and progression-free survival by enabling the immune system to better recognize and attack cancer cells. Patients receiving Imfinzi 500mg Injection after chemoradiation therapy experience longer periods without disease progression compared to those not on the drug.
Treatment of Liver cancer
In liver cancer, especially hepatocellular carcinoma, Imfinzi 500mg Injection offers benefits when combined with other treatments like bevacizumab. This combination improves overall survival and delays disease progression. This provides a valuable option for patients with advanced or unresectable liver cancer.
Treatment of Endometrial cancer
For endometrial cancer, particularly in cases that are recurrent or have spread, Imfinzi 500mg Injection works by boosting the immune system’s ability to fight cancer cells. This leads to improved response rates. Additionally, it results in longer progression-free survival in patients who may have exhausted other treatment options.
Treatment of Biliary tract cancer
Imfinzi 500mg Injection, when combined with chemotherapy, has been shown to extend survival in patients with advanced biliary tract cancer. The drug helps in shrinking tumors and delaying the progression of the disease, offering a new option for a cancer type that previously had limited effective treatments.

Side effects of Imfinzi Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Imfinzi
  • Cough
  • Nausea
  • Upper respiratory tract infection
  • Rash
  • Fatigue
  • Hair loss
  • Diarrhea
  • Pneumonitis
  • Breathlessness
  • Itching
  • Musculoskeletal (bone, muscle or joint) pain
  • Abdominal pain

How to use Imfinzi Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Imfinzi Injection works

Imfinzi 500mg Injection is a monoclonal antibody that targets and blocks a protein called PD-L1, which cancer cells use to hide from the immune system. It blocks PD-L1, and restores the ability of immune cells (T-cells) to recognize and attack cancer cells.

Quick tips

  • It is important to stick to your treatment schedule. If you miss a dose, contact your doctor immediately to reschedule.
  • Get regular check-ups and lab tests to track your response to the treatment and detect any potential issues early.
  • Drink plenty of fluids to manage some side effects like fatigue and dehydration.
  • Since Imfinzi 500mg Injection can weaken your immune system, avoid exposure to infections by practicing good hygiene and staying away from crowded places.
  • Be aware of serious side effects like difficulty breathing, severe abdominal pain, or jaundice. Seek medical attention immediately if these occur.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Imfinzi 500mg Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Imfinzi 500mg Injection is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Imfinzi 500mg Injection during breastfeeding is not available. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Imfinzi 500mg Injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Imfinzi 500mg Injection should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Imfinzi 500mg Injection in patients with liver disease.

Frequently asked questions

Imfinzi 500mg Injection is used to treat non-small cell lung cancer (NSCLC), biliary tract cancer, liver cancer, and endometrial cancer. It's often prescribed when these cancers are advanced or unresectable.
Imfinzi 500mg Injection is given as an intravenous (IV) infusion, typically in a hospital or clinic setting, under the supervision of a healthcare provider.
You may experience side effects like fatigue, cough, or appetite loss. It's important to report any severe symptoms to your doctor right away.
You should inform your doctor of all medications and supplements you are taking, as Imfinzi 500mg Injection can interact with other drugs.
Avoid exposure to infections, report any unusual symptoms, and discuss your medical history with your doctor, especially if you have autoimmune conditions, are pregnant, or breastfeeding.
The duration of treatment with Imfinzi 500mg Injection depends on your specific cancer type, response to the treatment, and overall health. Your doctor will determine the best treatment plan for you.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Monoclonal Antibodies (mAbs)

Related lab tests

Alpha-fetoprotein (AFP) L3 Fraction

References

  1. AstraZeneca. IMFINZI (durvalumab) [Product Information]. 2024. [Accessed 12 Aug. 2024] (online) Available from:
  2. Durvalumab [Prescribing Information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024. [Accessed 12 Aug. 2024] (online) Available from:
  3. Durvalumab for injection [Product Monograph]. Mississauga, Ontario: AstraZeneca Canada Inc.; 2024. [Accessed 12 Aug. 2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: AstraZeneca
Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Vendor Details

Country of origin: United kingdom

Lab tests offered by us

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