Graine Plus 40mg/10mg Tablet SR
Prescription Required
Product introduction
Graine Plus 40mg/10mg Tablet SR is a combination of two medicines that helps in preventing migraine. This medicine is not used for treatment of acute migraine attack.
Graine Plus 40mg/10mg Tablet SR should be taken on empty stomach, but try to have it same time regularly at a fixed time preferably at night. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Lifestyle modifications like avoiding stress, smoking, and processed food items may help this medicine work better.
Few common side effects of this medicine include weight gain, slow heart rate, tiredness, depression, drowsiness and cold extremities. It may cause sleepiness so try not to drive or do anything that requires mental focus or rise slowly while from sitting position. The drug has the ability to hide the symptoms of the blood sugar level, hence monitor your blood sugar level regularly as well as blood pressure while taking this medicine.
Before taking this medicine, let your doctor know if you have liver or kidney, or depression disease, or if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
Graine Plus 40mg/10mg Tablet SR should be taken on empty stomach, but try to have it same time regularly at a fixed time preferably at night. The dose and how often you take it depends on what you are taking it for. Your doctor will decide how much you need to improve your symptoms. You should take this medicine for as long as it is prescribed for you. Lifestyle modifications like avoiding stress, smoking, and processed food items may help this medicine work better.
Few common side effects of this medicine include weight gain, slow heart rate, tiredness, depression, drowsiness and cold extremities. It may cause sleepiness so try not to drive or do anything that requires mental focus or rise slowly while from sitting position. The drug has the ability to hide the symptoms of the blood sugar level, hence monitor your blood sugar level regularly as well as blood pressure while taking this medicine.
Before taking this medicine, let your doctor know if you have liver or kidney, or depression disease, or if you are pregnant or breastfeeding. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works.
Uses of Graine Plus Tablet SR
Benefits of Graine Plus Tablet SR
In Prevention of Migraine
Graine Plus 40mg/10mg Tablet SR helps improve the flow of blood in your brain and prevents abnormal activity of muscles that triggers migraines. It is a very effective medicine for preventing migraine attacks, however, it does not treat an attack that has already started. By preventing and reducing the frequency migraine attacks, the medicine can help you carry out your daily activities and improve your quality of life.
Side effects of Graine Plus Tablet SR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Graine Plus
- Weight gain
- Slow heart rate
- Tiredness
- Depression
- Drowsiness
- Abnormal dreams
- Cold extremities
How to use Graine Plus Tablet SR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Graine Plus 40mg/10mg Tablet SR is to be taken empty stomach.
How Graine Plus Tablet SR works
Graine Plus 40mg/10mg Tablet SR is a combination of two medicines: Propranolol and Flunarizine, which prevents migraine. Propranolol is a beta blocker and Flunarizine is a calcium channel blocker. They work by stabilizing the reactive nerve cells and increasing the threshold to migraine activation. They also inhibit cortical spreading depression (CSD- electric waves that move across the brain and cause pain and inflammation).
Safety advice
Alcohol
UNSAFE
It is unsafe to consume alcohol with Graine Plus 40mg/10mg Tablet SR.
Pregnancy
CONSULT YOUR DOCTOR
Graine Plus 40mg/10mg Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Graine Plus 40mg/10mg Tablet SR during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Graine Plus 40mg/10mg Tablet SR may cause side effects which could affect your ability to drive.
Graine Plus 40mg/10mg Tablet SR may cause visual disturbances, hallucinations, fatigue, mental confusion, dizziness or tiredness. This may affect your driving ability.
Graine Plus 40mg/10mg Tablet SR may cause visual disturbances, hallucinations, fatigue, mental confusion, dizziness or tiredness. This may affect your driving ability.
Kidney
SAFE IF PRESCRIBED
Graine Plus 40mg/10mg Tablet SR is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Graine Plus 40mg/10mg Tablet SR may not be needed in these patients. Please consult your doctor.
Liver
CAUTION
Graine Plus 40mg/10mg Tablet SR should be used with caution in patients with liver disease. Dose adjustment of Graine Plus 40mg/10mg Tablet SR may be needed. Please consult your doctor.
Regular monitoring of blood pressure is advisable for dose adjustment.
Regular monitoring of blood pressure is advisable for dose adjustment.
What if you forget to take Graine Plus Tablet SR?
If you miss a dose of Graine Plus 40mg/10mg Tablet SR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Graine Plus 40mg/10mg Tablet SR
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Quick tips
- You have been prescribed Graine Plus 40mg/10mg Tablet SR for prevention of migraine headaches.
- Do not take it to treat an acute attack of migraine.
- Some tips that may help avoid a migraine attack:
- Have your meals at the same time everyday
- Avoid bright lights and extreme temperatures
- Avoid loud music and noisy places
- Avoid chocolates, cheese, processed food, alcohol and smoking
- Get sufficient sleep and avoid stress
- It should be taken at night-time before going to bed.
- It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how Graine Plus 40mg/10mg Tablet SR affects you.
- keep taking it regularly every day, even if you don't have any symptoms.
Fact Box
Habit Forming
No
Therapeutic Class
CARDIAC
Patient concerns
FAQs
In which conditions is the use of Graine Plus 40mg/10mg Tablet SR contraindicated?
Use of Graine Plus 40mg/10mg Tablet SR is considered to be harmful for patients with allergy to any of the ingredients or excipients of this medicine. This medicine contains propranolol, so its use should be avoided in patients with asthma, slow heart rate, abnormal heart rhythms, or heart conditions like AV block or sick sinus syndrome. Since this medicine also contains flunarizine, the use of this medicine should be avoided in patients with the history of depression or Parkinson's disease.
What are the instructions for the storage and disposal of Graine Plus 40mg/10mg Tablet SR?
Keep Graine Plus 40mg/10mg Tablet SR in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Can I stop taking Graine Plus 40mg/10mg Tablet SR when my symptoms are improved?
Graine Plus 40mg/10mg Tablet SR is given as a prophylactic treatment for the prevention of migraine headaches. Do not stop taking this medicine until advised by your doctor as it may cause your migraine episodes to return. This medicine contains propranolol and a sudden withdrawal of propranolol may cause sweating, shaking, irregular or fast heartbeat, worsening of underlying angina or heart attack. You must take Graine Plus 40mg/10mg Tablet SR exactly as advised by your doctor.
Can Graine Plus 40mg/10mg Tablet SR be used for the treatment of a migraine headache?
No, Graine Plus 40mg/10mg Tablet SR does not help in relieving a migraine headache that has already started. It can only be used for preventing any new episode of migraine headaches.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Drugs.com. Flunarizine. [Accessed 25 Mar. 2019] (online) Available from:
- Drugs.com. Propranolol Pregnancy and Breastfeeding Warnings. [Accessed 20 Mar. 2019] (online) Available from:
- Flunarizine. High Wycombe, Buckinghamshire: Janssen Cilag Ltd.; 2009 [revised Feb. 2014]. [Accessed 11 Apr. 2019] (online) Available from:
Marketer details
Name: Apical Biologicals
Address: B-37, Rajeev Nagar, Sector-5, Rohini, Delhi-86
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.
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