Espzone 1000 Injection

Written By Dr. Lipika Khurana, PGDHHM, BDS

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 31 Mar 2026 | 02:31 PM (IST)

Espzone 1000 Injection is a combination medicine. It is prescribed to treat various types of bacterial infections. It fights against the microorganisms to prevent their growth and further spread of the infection.

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General Information

Contains

Cefoperazone (500mg)+ Sulbactam (500mg)

Marketer

Ronish Bioceuticals

Storage

Store below 30°C

The content is shown in English

Product introduction

Espzone 1000 Injection should only be administered under the supervision of a healthcare professional. Do not miss any scheduled appointments for taking this medicine. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine.

Some common side effects of this medicine are nausea, vomiting, diarrhea, indigestion, etc. If any of the side effects get aggravated, you must consult your doctor immediately. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help.

Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Pregnant or breastfeeding women should also consult with their doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. You must take adequate rest for a faster recovery, also take a healthy diet and drink plenty of water. Your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body.

Uses of Espzone Injection

Treatment of Bacterial infections

Benefits of Espzone Injection

Treatment of Bacterial infections
Espzone 1000 Injection contains two different medicines, Cefoperazone and Sulbactum, that work together to kill the bacteria that cause infections. Cefoperazone works by stopping the growth of bacteria. Sulbactam reduces resistance and enhances the activity of Cefoperazone against bacteria.

Espzone 1000 Injection can be used to treat many different bacterial infections such as ear, sinus, throat, lung, urinary tract, skin and soft tissues. This medicine usually makes you feel better within a few days, but you should continue taking it as prescribed even when you feel better to make sure that all bacteria are killed and do not become resistant.

Side effects of Espzone Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Espzone

Decreased white blood cell count (neutrophils)
Decreased white blood cell count (lymphocytes)
Decreased hemoglobin
Decreased hematocrit level
Low blood platelets
Coagulation disorder
Increased white blood cell count (eosinophils)
Diarrhea
Nausea
Increased alanine aminotransferase
Increased aspartate aminotransferase
Increased alkaline phosphatase level in blood
Vomiting
Increased bilirubin in the blood

How to use Espzone Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Espzone Injection works

Espzone 1000 Injection is a combination of two medicines: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefoperazone against bacteria.

All substitutes for Espzone 1000 Injection

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance.
Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Diarrhea may occur as a side effect. Taking probiotics along with Espzone 1000 Injection may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps.
Stop taking Espzone 1000 Injection and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Safety advice

Alcohol

UNSAFE

Consumption of alcohol with Espzone 1000 Injection may cause a disulfiram-like reaction, leading to symptoms such as flushing, increased heart rate, low blood pressure, nausea, lightheadedness, and severe headache.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Espzone 1000 Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CAUTION

Espzone 1000 Injection should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

SAFE

Espzone 1000 Injection does not usually affect your ability to drive.

Kidney

CAUTION

Espzone 1000 Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

CAUTION

Espzone 1000 Injection should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

What is Espzone 1000 Injection?

Espzone 1000 Injection is a combination of two medicines: Cefoperazone and Sulbactam. Cefoperazone is an antibiotic which works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Sulbactam is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Cefoperazone against bacteria.

How long does Espzone 1000 Injection takes to work?

Usually, Espzone 1000 Injection starts working soon after taking it. However, it may take some days to kill all the harmful bacteria and make you feel better.

What if I don't get better after using Espzone 1000 Injection?

Inform your doctor if you don't feel better after finishing the full course of treatment. Also, inform him if your symptoms are getting worse while using this medicine.

Fact Box

Habit Forming

Therapeutic Class

ANTI INFECTIVES

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Ronish Bioceuticals
Address: Ronish House, Nanhera Link Road, Kuldeep Nagar, Ambala Cantt

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Espzone 1000 Injection

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Espzone Injection

Benefits of Espzone Injection

Side effects of Espzone Injection

How to use Espzone Injection

How Espzone Injection works

All substitutes for Espzone 1000 Injection

Nexzone-S Injection

Vinazone 500mg/500mg Injection

Cefzone 500mg/500mg Injection

Pozone-S Injection

Pircef 500mg/500mg Injection

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Espzone 1000 Injection?

How long does Espzone 1000 Injection takes to work?

What if I don't get better after using Espzone 1000 Injection?

Fact Box

Habit Forming

Therapeutic Class

Related lab tests

Complete Blood Count

Peripheral Smear Examination

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests