Eplemac 25mg Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 11 Feb 2026 | 12:49 AM (IST)

Eplemac 25mg Tablet is a medicine known as a diuretic (water pill). It is mainly used in the treatment of heart failure and high blood pressure. It is also used to reduce swelling (edema) caused by some other conditions.

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Eplerenone (25mg)

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General Information

Contains

Eplerenone (25mg)

Marketer

Innovative Pharmaceuticals

Storage

Store below 30°C

The content is shown in English

Product introduction

Eplemac 25mg Tablet can be taken with or without food, but you should take it, in the same way, each time to get the most benefit. Taking it with food can reduce some side effects and taking it early in the day can prevent you from having to get up at night to go to the toilet. You should keep using this medicine as it has been prescribed, even if you feel well. If you stop taking it, your condition may get worse. If you are being treated for high blood pressure, lifestyle changes such as taking regular exercise and changes to your diet may increase the effectiveness of this medicine.

No common side effects have been reported with this medicine when used as directed. It is generally well tolerated by most people. However, if you notice any unusual symptoms or discomfort while taking this medicine, consult your doctor for advice.

You should be careful about using Eplemac 25mg Tablet if you have kidney problems or are unable to urinate. Also, let your healthcare team know about all other medications you are using as they may affect, or be affected by, this medicine. This medicine should only be used if it is clearly needed during pregnancy and while breastfeeding. While using this medicine, you may be advised to limit your intake of salt or salt substitutes, and you should have your blood pressure checked frequently. Some other tests will be done to monitor your progress.

Uses of Eplemac Tablet

Hypertension (high blood pressure)

Benefits of Eplemac Tablet

Hypertension (high blood pressure)
Hypertension (high blood pressure) is a condition in which the force of blood against the walls of the blood vessels remains consistently high, increasing the risk of heart disease, stroke, and kidney problems. Eplemac 25mg Tablet helps lower blood pressure by reducing excess salt and water in the body, which decreases fluid buildup and eases the workload on the heart. This helps control blood pressure levels and supports the long-term health of the heart, blood vessels, and kidneys.

Side effects of Eplemac Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Eplemac

No common side effects seen

How to use Eplemac Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Eplemac 25mg Tablet may be taken with or without food.

How Eplemac Tablet works

Eplemac 25mg Tablet is a potassium-sparing diuretic. It works by stopping aldosterone (a natural substance) from increasing your blood pressure. It also reduces the fluid around your heart. This helps improve your heart function after a heart attack and can help prevent heart attacks, strokes or heart failure getting worse.

All substitutes for Eplemac 25mg Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Eplemac 25mg Tablet helps remove fluid from your body when used with other drugs.
It can make you feel dizzy for the first few days. Do not drive or do anything requiring concentration until you know how Eplemac 25mg Tablet affects you.
It may increase the level of potassium in your blood. Avoid taking potassium supplements and potassium-rich foods such as banana and broccoli.
Your doctor will regularly check your kidney function and the amount of potassium in your blood while you are on this medicine.
Notify your doctor if you experience dizziness, diarrhea, vomiting, fast or irregular heartbeat, swelling in feet, or difficulty breathing.
Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Eplemac 25mg Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Eplemac 25mg Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Eplemac 25mg Tablet during breastfeeding is not available. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Eplemac 25mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CAUTION

Eplemac 25mg Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Eplemac 25mg Tablet is unsafe to use in patients with liver disease and should be avoided.

Interaction with drugs

Taking Eplemac with any of the following medicines can modify the effect of either of them and cause some undesirable side effects

Life-threatening

Atazanavir (Oral Route)

Do not consume Eplerenone with Atazanavir. Atazanavir may raise blood levels of Eplerenone.

Life-threatening

Clarithromycin (Oral Route)

Do not consume Eplerenone with Clarithromycin. Clarithromycin may raise blood levels of Eplerenone.

Life-threatening

Clarithromycin (Injection Route)

Do not consume Eplerenone with Clarithromycin. Clarithromycin may raise blood levels of Eplerenone.

Life-threatening

Clarithromycin (Oral Route)

Do not consume Eplerenone with Clarithromycin. Clarithromycin may raise blood levels of Eplerenone.

Life-threatening

Clarithromycin (Oral Route)

Do not consume Eplerenone with Clarithromycin. Clarithromycin may raise blood levels of Eplerenone.

Frequently asked questions

What does Eplemac 25mg Tablet do? Is it a beta blocker or a diuretic?

Eplemac 25mg Tablet is a potassium-sparing diuretic. It is prescribed with other medicines to control increased blood pressure and to treat heart failure in patients who have had a heart attack. It is not a beta blocker but mineralocorticoid receptor blocker.

How long does Eplemac 25mg Tablet take to work?

Eplemac 25mg Tablet controls high blood pressure but does not cure it. You may not see any improvement because high blood pressure does not have any symptoms. But, if you get your blood pressure checked, you may notice a change within 2 weeks of starting Eplemac 25mg Tablet. However, the medicine may take 4 weeks or longer to show its maximum benefits.

Does Eplemac 25mg Tablet cause erectile dysfunction?

No, Eplemac 25mg Tablet does not cause erectile dysfunction. Eplemac 25mg Tablet does not have any effect on fertility, in both males and females.

My blood pressure is now controlled, still the doctor has asked me to continue the treatment. Can I stop Eplemac 25mg Tablet?

No, you should not stop Eplemac 25mg Tablet. If your doctor has advised you to continue treatment, keep taking it. Eplemac 25mg Tablet does not cure blood pressure, but keeps the blood pressure in control. Therefore, keep taking the medicine even if your blood pressure is controlled. Stopping it may make your condition worse and you may have unwanted side effects.

Eplemac 25mg Tablet is a potassium-sparing diuretic. Does this mean that I will have more potassium in my body? Will it be beneficial for me?

Potassium-sparing diuretic are those medicines which increase the urination without causing any loss in potassium levels. Eplemac 25mg Tablet allows sodium loss by body in exchange for potassium which is retained. It may result in an increase in the levels of potassium. Therefore, your doctor may monitor your potassium levels continuously. You may need to get it measured before starting Eplemac 25mg Tablet, within the first week and one month after the start of treatment or after a change in dose. Potassium levels above normal range are not good for you or anyone.

I had been using Losartan for quite some time and was tolerating it well. Now my doctor has prescribed me Eplemac 25mg Tablet along with Hydrochlorothiazide. I want to know why he just could not add Eplemac 25mg Tablet with Losartan?

It could be possible that Losartan was not able to control your blood pressure adequately. Therefore, your doctor may have suggested an alternative medicine for blood pressure control (Eplemac 25mg Tablet), but Eplerenone when taken with Losartan can enhance the chances of raised potassium levels which could be harmful for you. To prevent this rise in potassium levels, the combination of Eplemac 25mg Tablet with hydrochlorothiazide may have been prescribed.

Is there anything I need to be careful about if I am taking aspirin and have now started Eplemac 25mg Tablet?

Aspirin may interfere with the working of Eplemac 25mg Tablet due to which your blood pressure may not get adequately controlled. Aspirin and Eplemac 25mg Tablet may increase the chances of rise in potassium levels in patients with kidney problems. Therefore, if both are to be used together, keep monitoring your blood pressure and potassium levels.

Fact Box

Chemical Class

Spironolactone derivative

Habit Forming

Therapeutic Class

CARDIAC

Action Class

Potassium-Sparing Diuretics

Related lab tests

Kidney Function Test

References

Reilly RF, Jackson EK. Regulation of Renal Function and Vascular Volume. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 692-95.
Pfeffer MA, Opie LH. Inhibitors of the Renin-Angiotensin-Aldosterone System. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 159-61.
Eplerenone. New York, New York: Pfizer, Inc.; 2002 [revised May 2016]. [Accessed 18 Mar. 2019] (online) Available from:
Eplerenone. West Ryde, New South Wales: Pfizer Australia Pty Ltd.; 2014. [Accessed 17 Jun. 2019] (online) Available from:
Central Drugs Standard Control Organisation (CDSCO). Eplerenone. [Accessed 18 Mar. 2019] (online) Available from:
Eplerenone [Prescribing Information]. New York, NY: G.D. Searle LLC; 2021. [Accessed 22 Jun. 2023] (online) Available from:
Hughes JC, Cassagnol M. Eplerenone. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. [Accessed 22 Jun. 2023] (online) Available from:
Eplerenone. Berkeley Heights, NJ: Breckenridge Pharmaceutical, Inc.; 2025 [Accessed 11 Jan. 2026] (online). Available from:
Eplerenone. New York, NY: Pfizer; 2021 [Accessed 11 Jan. 2026] (online). Available from:

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Innovative Pharmaceuticals
Address: 501, Pearl Arcade, J.P.Road, Andheri (West), Mumbai-58, (Mahrashtra) INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

Why we need a prescription?

Eplemac 25mg Tablet

Save more with additional offers

General Information

Contains

Marketer

Storage

Product introduction

Uses of Eplemac Tablet

Benefits of Eplemac Tablet

Side effects of Eplemac Tablet

How to use Eplemac Tablet

How Eplemac Tablet works

All substitutes for Eplemac 25mg Tablet

Planep Tablet

Exenta 25 Tablet

Eplehef 25 Tablet

Epnone 25mg Tablet

Ezuric 25mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Interaction with drugs

Atazanavir (Oral Route)

Clarithromycin (Oral Route)

Clarithromycin (Injection Route)

Clarithromycin (Oral Route)

Clarithromycin (Oral Route)

Frequently asked questions

What does Eplemac 25mg Tablet do? Is it a beta blocker or a diuretic?

How long does Eplemac 25mg Tablet take to work?

Does Eplemac 25mg Tablet cause erectile dysfunction?

My blood pressure is now controlled, still the doctor has asked me to continue the treatment. Can I stop Eplemac 25mg Tablet?

Eplemac 25mg Tablet is a potassium-sparing diuretic. Does this mean that I will have more potassium in my body? Will it be beneficial for me?

I had been using Losartan for quite some time and was tolerating it well. Now my doctor has prescribed me Eplemac 25mg Tablet along with Hydrochlorothiazide. I want to know why he just could not add Eplemac 25mg Tablet with Losartan?

Is there anything I need to be careful about if I am taking aspirin and have now started Eplemac 25mg Tablet?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

Related lab tests

Kidney Function Test

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

Related/Popular tests