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18 Feb 2020 | 05:25 PM (IST)
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Overview

Introduction

Epalrica-M Tablet SR is a medicine used in the treatment of diabetic nerve disease. It protect the nerve fibers from damage and promotes regeneration of nerve cells. It is used along with other blood sugar lowering medications in order to prevent further nerve injury.

Epalrica-M Tablet SR may be taken with or without food, but you should try to take it at the same time every day. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at risk of serious complications like kidney damage and blindness. This medicine is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.

The most common side effects of this medicine include nausea, vomiting, and increased liver enzymes. However, these are temporary and usually subside on their own. Please consult your doctor if these do not resolve or persist for a longer duration.

Before taking this medicine, inform your doctor if you have any kidney or liver problems or a urinary tract infection or if you are on water pills (diuretics). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects. Monitor your blood sugar levels regularly while taking this medicine.

Uses of Epalrica-M Tablet SR

Side effects of Epalrica-M Tablet SR

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Epalrica-M

  • Nausea
  • Vomiting
  • Increased liver enzymes

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Nausea
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop from feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Vomiting
    You can help yourself by eating small, frequent meals rather than large ones and drinking plenty of fluids. Eat slowly. Avoid fatty, fried, spicy and very sweet foods. Eat cold or slightly warm food if the smell of cooked or cooking food makes you feel sick. Get plenty of fresh air. You could also try chewing ginger or drinking ginger tea. Eat bananas to replace potassium in your blood which can drop if you are sick (vomit). Use oral rehydration salts to replace vitamins and minerals lost through being sick. There are some medicines that can help you stop feeling sick. Speak to your doctor if your condition does not improve.
  • Coping with Increased liver enzymes
    There may be no symptoms, so your doctor should carry out a blood test and give you advice. Some lifestyle changes can bring down levels of liver enzymes. In general, you will need to stop drinking alcohol or limit the amount you drink, lose weight and keep active. Drink plenty of fluids to avoid dehydration. Eat a healthy diet. Some particular foods like nuts, fatty fish, coffee, tea, olive oil, sprouts and bananas may be beneficial. Try to control stress as this can make your symptoms worse.

How to use Epalrica-M Tablet SR

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Epalrica-M Tablet SR may be taken with or without food, but it is better to take it at a fixed time.

How Epalrica-M Tablet SR works

Epalrica-M Tablet SR is a combination of two medicines: Epalrestat and methylcobalamin which treat diabetic nerve disease. Epalrestat is an aldose reductase inhibitor. It blocks the accumulation of sorbitol in cells, which has been related in causing diabetic nerve disease. Methylcobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells.

Safety Advice

Alcohol
UNSAFE
It is unsafe to consume alcohol with Epalrica-M Tablet SR.
Pregnancy
CONSULT YOUR DOCTOR
Epalrica-M Tablet SR may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Information regarding the use of Epalrica-M Tablet SR during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether Epalrica-M Tablet SR alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of Epalrica-M Tablet SR in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Epalrica-M Tablet SR in patients with liver disease. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Epalrica-M Tablet SR
₹20.93/Tablet SR
Alrista Plus Tablet SR
Macleods Pharmaceuticals Pvt Ltd
₹18.9/Tablet SR
save 10%
Epineuron SR Tablet
Aristo Pharmaceuticals Pvt Ltd
₹19.71/Tablet SR
save 6%
Epalpex-M SR Tablet
Shilpex Pharmysis
₹24.25/Tablet SR
16% costlier
₹25.48/Tablet SR
22% costlier

Quick Tips

  • Take it only as per the dose and duration prescribed by your doctor. 
  • Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease.
  • Inform your doctor if you have:
    • Cut or sore on your feet that is infectious or not healing
    • Burning or tingling sensation in arm or feet that hamper your routine activities
    • Trouble in digestion, urination, or sexual functioning
    • Dizziness
  • To prevent diabetic nerve pain, wear proper footwear and examine your feet every day to detect lesions early.
  • Monitor your blood sugar level regularly.
  • Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Fact Box

Habit Forming
No

Patient Concerns

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My dad is a diabetic patient now a days he is also suffering from leg pains associated with nerve pains from back side of left leg. How do i over come with this kind of situation to reduce the pains and keep it normal.
Dr. Sanjay Bhatt
Physician
Good sugar control and Tab. Pregastar M
I am suffering from sciatica nerve pain
Dr. Mehtab Baig
Orthopaedic Physiotherapy
How many days, have you any m. R i. Or xray reports send meU can do all exercises 10 times twice a day before meals
arrow
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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Sharma SR, Sharma N. Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective. Ann Indian Acad Neurol. 2008;11(4):231-35. [Accecssed 08 Apr. 2019] (online) Available from:External Link
  2. National Institues of Health. Vitamin B12. [Accessed 08 Apr. 2019] (online) Available from:External Link
  3. Hotta N, Akanuma Y, Kawamori R, et al. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care. 2006;29(7):1538-44. [Accessed 08 Apr. 2019] (online) Available from:External Link

Manufacturer/Marketer Address

Exeltis - Ordain Health Care Global Pvt Ltd , Khivraj Complex - II, 4th Floor, No: 480, Anna Salai, Nandanam, Chennai - 600 035, Tamil Nadu, India.
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