


Epalrest-M Tablet
Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 25 Nov 2025 | 03:07 PM (IST)

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Product introduction
Epalrest-M Tablet may be taken with or without food, but you should try to take it at the same time every day. The dose will be decided by your doctor. Do not stop taking it without asking your doctor. If you do, your blood sugar levels may increase and put you at risk of serious complications like kidney damage and blindness. This medicine is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor.
The most common side effects of this medicine include nausea, vomiting, and increased liver enzymes. However, these are temporary and usually subside on their own. Please consult your doctor if these do not resolve or persist for a longer duration.
Before taking this medicine, inform your doctor if you have any kidney or liver problems or a urinary tract infection or if you are on water pills (diuretics). Pregnant or breastfeeding women should also consult their doctor before taking it. Avoid excessive alcohol intake while taking it as this may increase the risk of developing some side effects. Monitor your blood sugar levels regularly while taking this medicine.
Uses of Epalrest-M Tablet
Benefits of Epalrest-M Tablet
Epalrest-M Tablet is a medicine used to treat long-lasting (chronic) pain caused by nerve damage due to diabetes. It reduces pain and its associated symptoms such as mood changes, sleep problems, and tiredness. It interferes with pain signals that travel through the damaged nerves and the brain and also improves nerve conduction. Taking Epalrest-M Tablet regularly will improve your physical and social functioning and overall quality of life.
Side effects of Epalrest-M Tablet
- Nausea
- Vomiting
- Increased liver enzymes
How to use Epalrest-M Tablet
How Epalrest-M Tablet works
Quick tips
- Take it only as per the dose and duration prescribed by your doctor.Â
- Adherence to antidiabetic therapy can delay the onset of or prevent diabetic nerve disease.
- Inform your doctor if you have:
- Cut or sore on your feet that is infectious or not healing
- Burning or tingling sensation in arm or feet that hamper your routine activities
- Trouble in digestion, urination, or sexual functioning
- Dizziness
- To prevent diabetic nerve pain, wear proper footwear and examine your feet every day to detect lesions early.
- Monitor your blood sugar level regularly.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver
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References
- Sharma SR, Sharma N. Epalrestat, an aldose reductase inhibitor, in diabetic neuropathy: An Indian perspective. Ann Indian Acad Neurol. 2008;11(4):231-35. [Accecssed 08 Apr. 2019] (online) Available from:
- National Institues of Health. Vitamin B12. [Accessed 08 Apr. 2019] (online) Available from:
- Hotta N, Akanuma Y, Kawamori R, et al. Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial. Diabetes Care. 2006;29(7):1538-44. [Accessed 08 Apr. 2019] (online) Available from:




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Address: 42/44, Babu Genu Road, Shop No. 06, 2nd Floor, Om Shanti Co-op Housing Society, Kalbadevi Road, Mumbai-400002. (India)
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Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)













