


Entodase Injection
Hyaluronidase (1500IU)
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Entodase Injection is used as a preservative in combination with other medicines. It enhances the absorption and spread of fluids for hydration, improves the dispersion and effectiveness of injected drugs, and improves the absorption of contrast agents used in certain imaging tests, like subcutaneous urography.
Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 25 Nov 2025 | 03:05 PM (IST)
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General Information
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Product introduction
Generally, Entodase Injection comes in combination with injectable medicines. It must be administered as per prescription under the supervision of a doctor or a nurse. Let your doctor know if you have any known allergies to this medication.
Entodase Injection is a safe medicine and has minimal or no side effects. However, some patients might experience injection site reactions such as redness, swelling, and pain. Let your doctor know if they bother you.
Uses of Entodase Injection
- Preservative
Benefits of Entodase Injection
Preservative
Entodase Injection is used as a preservative to prevent damage to the original form of the medicine that is given as an injection by a doctor or nurse. If it is not present, harmful organisms can contaminate the solution and cause infections or reactions in the person who takes any such medicine. It also acts as a solvent for certain medicines and helps in better absorption of the medicine in our body.
Entodase Injection is used as a preservative to prevent damage to the original form of the medicine that is given as an injection by a doctor or nurse. If it is not present, harmful organisms can contaminate the solution and cause infections or reactions in the person who takes any such medicine. It also acts as a solvent for certain medicines and helps in better absorption of the medicine in our body.
Side effects of Entodase Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Entodase
- Injection site reactions (pain, swelling, redness)
How to use Entodase Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Entodase Injection works
Entodase Injection is an enzyme that breaks down hyaluronic acid, a natural substance in the body that acts like a gel or barrier under the skin. By breaking down this barrier, Entodase Injection temporarily increases the permeability of the tissue, allowing fluids, medications, or contrast agents to spread and be absorbed more easily. This helps in faster hydration, better dispersion of injected drugs, and improved resorption of imaging agents, making treatments and diagnostic procedures more effective. In simple terms, it opens up the tissue to help things move and absorb more quickly.
All substitutes for Entodase Injection
For information purposes only. Consult a doctor before taking any medicine.
Quick tips
- Entodase Injection helps with the absorption of injections that are given into a muscle or under the skin.
- It may also help in the easy reabsorption of excess fluid and blood in the tissues.
- Your doctor or nurse will give the injection either into a muscle or under the skin.
- It may cause temporary irritation, swelling, or bruising at the injection site. Inform your doctor if this persists.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Entodase Injection. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
The safety of Entodase Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Entodase Injection during breastfeeding is not available. Please consult your doctor.

Driving
SAFE
Entodase Injection does not usually affect your ability to drive.

Kidney
CONSULT YOUR DOCTOR
There is limited data available on the use of Entodase Injection in patients with kidney disease. Please consult your doctor.

Liver
CONSULT YOUR DOCTOR
There is limited data available on the use of Entodase Injection in patients with liver disease.
Frequently asked questions
Entodase Injection is a medicine that helps other injected drugs or fluids spread and absorb more easily under the skin. It's often used to enhance the effects of other injections, to hydrate patients through the skin (hypodermoclysis), or for diagnostic procedures like subcutaneous urography.
No, Entodase Injection should not be given through a vein (IV) because it gets broken down quickly and won’t work properly. It is meant to be used under the skin or in specific tissue areas only.
People who are allergic to hyaluronidase or any ingredients present in Entodase Injection should not receive Entodase Injection. A skin test may be done first to check for allergies.
Although rare, serious side effects of Entodase Injection can include allergic reactions (rash, swelling, or difficulty breathing), anaphylaxis-like reactions if used near the eye or by mistake in the vein, and spreading of infection if injected into an inflamed or infected area.
Yes, but Entodase Injection may increase how quickly the anesthetic works and wears off, and might increase the chance of side effects from the anesthetic.
Entodase Injection works quickly to help other drugs spread.
No. But Entodase Injection should not be injected into or around an infected or acutely inflamed area because of the danger of spreading to a localized infection. Entodase Injection should not be used to reduce the swelling of bites or stings.
You should report any adverse reactions, including redness, swelling, itching, or pain at the injection site, to your doctor.
Entodase Injection rarely causes injection site skin scarring when done correctly. It is advised to always take Entodase Injection from a doctor or a trained professional in a clinical setting.
Fact Box
Chemical Class
Peptides
Habit Forming
No
Therapeutic Class
BLOOD RELATED
Action Class
Additives & Preservatives
References
- Hyaluronidase [EMC SmPC]. Wrexham Industrial Estate, Wrexham: Wockhardt UK Ltd.; 2015. [Accessed 07 Apr. 2019] (online) Available from:
- Hyaluronidase. Bridgewater, NJ: Bausch & Lomb Incorporated;. [Accessed 03 Apr. 2025] (online) Available from:
- Hyaluronidase. Lake Forest, IL: Akorn, Inc.; 2015 [Accessed 03 Apr. 2025] (online) Available from:
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Disclaimer
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Marketer details
Name: Entod Pharmaceuticals Ltd
Address: Ashirwad building, S.V.Road, Opp. Badi Masjid, Bandra(W), Mumbai-400050, INDIA
Address: Ashirwad building, S.V.Road, Opp. Badi Masjid, Bandra(W), Mumbai-400050, INDIA
Vendor Details
Country of origin: India
Lab tests offered by us
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)
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