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Hyaluronidase

Written By Dr. Anuj SainiReviewed By Dr. Rajeev Sharma
Last updated 10 Apr 2025 | 04:35 AM (UTC)

Hyaluronidase Uses

Hyaluronidase is used as preservative.

How Hyaluronidase works

Hyaluronidase increase the permeability of connective tissue through the hydrolysis of hyaluronic acid. Hyaluronidase hydrolyzes hyaluronic acid by splitting the glucosaminidic bond between C1 of the glucosamine moiety and C4 of glucuronic acid. This temporarily decreases the viscosity of the cellular cement and increases diffusion of injected fluids or of localized transudates or exudates, thus facilitating their absorption.
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Expert advice for Hyaluronidase

  • Hyaluronidase helps with the absorption of injections that are given into a muscle or under the skin.
  • It may also be used to enable excess fluids and blood in the tissues to be more easily re-absorbed.
  • Your doctor or nurse will give the injection either into a muscle or under the skin.
  • It may cause temporary irritation, swelling or bruising at the injection site. Inform your doctor if this persists.
  • Inform your doctor if you are pregnant or breastfeeding.