Overview
Uses and benefits
Side effects
How to use
How drug works
Safety advice
Missed dose
All substitutes
Quick tips
Fact box
Patient concerns
FAQs

Author Details

Written By

Dr. Mayank

Pharm.D

Reviewed By

Dr. Sachin Gupta

MD Pharmacology, MBBS

Last updated

25 Nov 2025 | 10:54 PM (IST)

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Dox Plus 10mg/10mg/2.5mg Tablet

Prescription Required

Marketer

Mak Pharmaceuticals

SALT COMPOSITION

Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg) + Folic Acid (2.5mg)

Storage

Store below 30°C

View available alternative with same salt composition

Click here to view all substitutes

Product introduction

Dox Plus 10mg/10mg/2.5mg Tablet is a combination medicine used in the treatment of nausea or vomiting during pregnancy. It blocks signals to reach the brain that trigger the feeling of nausea and vomiting.

Dox Plus 10mg/10mg/2.5mg Tablet is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are dryness in the mouth, constipation, and lightheadedness. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine can also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Uses of Dox Plus Tablet

Treatment of Nausea and vomiting in pregnancy

Benefits of Dox Plus Tablet

In Treatment of Nausea and vomiting in pregnancy

Dox Plus 10mg/10mg/2.5mg Tablet blocks the action of chemicals in the body that can make you feel or be sick during pregnancy. This medicine helps you cope up with nausea or vomiting that occurs due to hormonal changes during pregnancy and helps you complete the term without much discomfort. It also contains nutritional supplements that improve your baby’s immune system, enhance the baby’s brain development and also help reduce nausea and vomiting during pregnancy.

Side effects of Dox Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Dox Plus

Sleepiness
Dizziness
Fatigue
Dryness in mouth
Constipation

How to use Dox Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dox Plus 10mg/10mg/2.5mg Tablet should be taken with or after food.

How Dox Plus Tablet works

Dox Plus 10mg/10mg/2.5mg Tablet is a combination of three medicines: doxylamine, vitamin B6 (pyridoxine) and folic acid, which treats nausea and vomiting associated with pregnancy.

Safety advice

Alcohol

UNSAFE

Do not drink alcohol while you are taking this medicine. Dox Plus 10mg/10mg/2.5mg Tablet may cause excessive drowsiness when taken with alcohol.

Pregnancy

SAFE IF PRESCRIBED

Dox Plus 10mg/10mg/2.5mg Tablet is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.

Breast feeding

CONSULT YOUR DOCTOR

Dox Plus 10mg/10mg/2.5mg Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.

Driving

CONSULT YOUR DOCTOR

It is not known whether Dox Plus 10mg/10mg/2.5mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.

Kidney

CONSULT YOUR DOCTOR

There is limited data available on the use of Dox Plus 10mg/10mg/2.5mg Tablet in patients with kidney disease. Please consult your doctor.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Dox Plus 10mg/10mg/2.5mg Tablet in patients with liver disease.

What if you forget to take Dox Plus Tablet?

If you miss a dose of Dox Plus 10mg/10mg/2.5mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.

Dox Plus 10mg/10mg/2.5mg Tablet

₹9.18/Tablet

Doxinate Plus Tablet

Maneesh Pharmaceuticals Ltd

₹9.83/tablet

7% costlier

Rest Aid Plus Tablet

Overseas Healthcare Pvt Ltd

₹6.97/tablet

24% cheaper

Sysfol Plus Tablet

Systopic Laboratories Pvt Ltd

₹4.66/tablet

49% cheaper

Revomin Tablet

Endocard India Pvt Ltd

₹6.36/tablet

31% cheaper

Vomilast Tablet

Mankind Pharma Ltd

₹6.7/tablet

27% cheaper

View all substitutes

Quick tips

Dox Plus 10mg/10mg/2.5mg Tablet helps treat nausea and vomiting in pregnant women whose symptoms did not improved using diet and lifestyle changes.
Take it on an empty stomach with a glass of water.
It may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
Do not take it with other sedating medications such as cough and cold medications as the combination could worsen dizziness leading to falls or other accidents

Fact Box

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Patient concerns

Normal checkup of my eye i dont use any eyeglass

Dr. Richa Jain

Ophthalmology

Here can't be done. . Visit dox

Insomnia depression mood changes Took spectra 75 spectra 25 spectra 10 Now taking DOX 10

Dr. Jyoti Kapoor Madan

Psychiatry

Depression is a persistent state of sadness that is the result of interaction between one's inner biological and psychological state and gets triggered of with environmental stressors. Endogenous depression occurs without any noticeable environmental stressors. Psychological symptoms include lack of interest, negative thinking, irritability, frustration, feeling demotivated etc. Somatic symptoms like fatigue/ weakness/ lack of sleep/ lack of appetite and other physical symptoms are common. Anxiety is common. In severe cases one may feel helpless and hopeless enough to wish for death or attempt suicide. Treatment includes physical and psychiatric work up following which medicines can be prescribed. In milder cases, psychotherapy or counselling is recommended.

I am in the first month of pregnancy and I am experiencing nausea, vomiting, stomach pain (moderate to severe) as well as discomfort. Current medications is Susten SR 200 (OD), Duvadilan retard (OD), Doxinate (BD), Folverine D (OD), Fertigyn 500 (1 amp weekly) and aciloc 150 (BD). What should I do to ease my situation. Please suggest

Dr. Suman Rao

Obstetrics and Gynaecology

The med suggested are to support of pregnancy and for acidity and nausea and vomiting. Continue the same. You can upgrade the med for vomiting after consulting your

What are the instructions for storage and disposal of Dox Plus 10mg/10mg/2.5mg Tablet?

Keep this medicine in the container or the pack it came in, tightly closed. Store it at as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

Can I take a higher than the recommended dose of this medicine?

No, taking a higher than the recommended dose of Dox Plus 10mg/10mg/2.5mg Tablet can cause increased side effects. If you are experiencing increased severity of nausea or vomiting, which is not relieved by the recommended doses, please consult your doctor for re-evaluation.

Can the use of Dox Plus 10mg/10mg/2.5mg Tablet cause drowsiness or sleepiness?

Yes, one of the common side effects of Dox Plus 10mg/10mg/2.5mg Tablet is drowsiness. Do not drive, operate heavy machinery or engage in other activities that need your full attention. Do not drink alcohol or take any medicines that may depress the central nervous system like cough and cold medicines, certain pain medicines, and medicines that help you sleep, while you are taking Dox Plus 10mg/10mg/2.5mg Tablet. Severe drowsiness can happen or it can become worse and cause falls or accidents.

Can the use of Dox Plus 10mg/10mg/2.5mg Tablet cause dry mouth?

Yes, the use of Dox Plus 10mg/10mg/2.5mg Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. Try to avoid foods that are acidic (like lemons), spicy and salty.

Can a pregnant woman take Dox Plus 10mg/10mg/2.5mg Tablet?

Yes, it is safe to take Dox Plus 10mg/10mg/2.5mg Tablet in pregnant women. In fact, this medicine is used to treat nausea and vomiting in pregnant women. It is mainly recommended to those women whose symptoms have not improved after changing their diet or using other non-medicine treatments.

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Disclaimer:

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

Doxylamine succinate and pyridoxine hydrochloride. Blainville, Québec: Duchesnay Inc.; 1976 [revised Nov. 2016]. [Accessed 12 Apr. 2019] (online) Available from:
DailyMed. Doxylamine succinate and pyridoxine hydrochloride. [Accessed 12 Apr. 2019] (online) Available from:
ScienceDirect. Vitamin B6. [Accessed 12 Apr. 2019] (online) Available from:
DailyMed. Pyridoxine hydrochloride. [Accessed 12 Apr. 2019] (online) Available from: