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Sysfol Plus Tablet is a combination medicine used in the treatment of nausea or vomiting during pregnancy. It blocks signals to reach the brain that trigger the feeling of nausea and vomiting.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS,
Last updated on 17 Jan 2026 | 02:56 PM (IST)
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General Information

Contains

Doxylamine (10mg)+ Vitamin B6 (Pyridoxine) (10mg)+ Folic Acid (2.5mg)

Marketer

Systopic Laboratories Pvt Ltd

Storage

Store below 25°C
The content is shown in English
Sysfol Plus Tablet image
Sysfol Plus Tablet image
Sysfol Plus Tablet image
Sysfol Plus Tablet image
Sysfol Plus Tablet image
Sysfol Plus Tablet image

Product introduction

Sysfol Plus Tablet is taken with or without food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are dryness in the mouth, constipation, and lightheadedness. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. This medicine can also cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness.

Uses of Sysfol Plus Tablet

Benefits of Sysfol Plus Tablet

Treatment of Nausea and vomiting in pregnancy
Sysfol Plus Tablet blocks the action of chemicals in the body that can make you feel or be sick during pregnancy. This medicine helps you cope up with nausea or vomiting that occurs due to hormonal changes during pregnancy and helps you complete the term without much discomfort. It also contains nutritional supplements that improve your baby’s immune system, enhance the baby’s brain development and also help reduce nausea and vomiting during pregnancy.

Side effects of Sysfol Plus Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Sysfol Plus
  • Sleepiness
  • Dizziness
  • Fatigue
  • Dryness in mouth
  • Constipation

How to use Sysfol Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sysfol Plus Tablet is to be taken on an empty stomach.

How Sysfol Plus Tablet works

Sysfol Plus Tablet is a combination of three medicines: doxylamine, vitamin B6 (pyridoxine) and folic acid, which treats nausea and vomiting associated with pregnancy.

All substitutes for Sysfol Plus Tablet

For information purposes only. Consult a doctor before taking any medicine.

Doxinate Plus Tablet

by Maneesh Pharmaceuticals Ltd
₹9.77/tablet
111% costlier
<h3 class=bodySemiBold>Doxinate Plus Tablet</h3>

Rest Aid Plus Tablet

by Overseas Healthcare Pvt Ltd
₹7.67/tablet
66% costlier
<h3 class=bodySemiBold>Rest Aid Plus Tablet</h3>

Revomin Tablet

by Endocard India Pvt Ltd
₹6.43/tablet
39% costlier
<h3 class=bodySemiBold>Revomin Tablet</h3>

Vomilast Tablet

by Mankind Pharma Ltd
₹6.73/tablet
45% costlier
<h3 class=bodySemiBold>Vomilast Tablet</h3>

Pregnidoxin Plus Tablet

by Dr Reddy's Laboratories Ltd
₹8.1/tablet
75% costlier
<h3 class=bodySemiBold>Pregnidoxin Plus Tablet</h3>

Quick tips

  • Sysfol Plus Tablet helps treat nausea and vomiting in pregnant women whose symptoms did not improved using diet and lifestyle changes. 
  • Take it on an empty stomach with a glass of water.
  • It may cause dizziness. Do not drive or do anything requiring concentration until you know how it affects you.
  • Do not take it with other sedating medications such as cough and cold medications as the combination could worsen dizziness leading to falls or other accidents

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Sysfol Plus Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Sysfol Plus Tablet is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Sysfol Plus Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Sysfol Plus Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Kidney

Kidney

CAUTION
Sysfol Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Sysfol Plus Tablet in patients with liver disease.

Frequently asked questions

Keep this medicine in the container or the pack it came in, tightly closed. Store it at as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
No, taking a higher than the recommended dose of Sysfol Plus Tablet can cause increased side effects. If you are experiencing increased severity of nausea or vomiting, which is not relieved by the recommended doses, please consult your doctor for re-evaluation.
Yes, one of the common side effects of Sysfol Plus Tablet is drowsiness. Do not drive, operate heavy machinery or engage in other activities that need your full attention. Do not drink alcohol or take any medicines that may depress the central nervous system like cough and cold medicines, certain pain medicines, and medicines that help you sleep, while you are taking Sysfol Plus Tablet. Severe drowsiness can happen or it can become worse and cause falls or accidents.
Yes, the use of Sysfol Plus Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. Try to avoid foods that are acidic (like lemons), spicy and salty.
Yes, it is safe to take Sysfol Plus Tablet in pregnant women. In fact, this medicine is used to treat nausea and vomiting in pregnant women. It is mainly recommended to those women whose symptoms have not improved after changing their diet or using other non-medicine treatments.

Fact Box

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

References

  1. Doxylamine succinate and pyridoxine hydrochloride. Blainville, Québec: Duchesnay Inc.; 1976 [revised Nov. 2016]. [Accessed 12 Apr. 2019] (online) Available from:
  2. DailyMed. Doxylamine succinate and pyridoxine hydrochloride. [Accessed 12 Apr. 2019] (online) Available from:
  3. ScienceDirect. Vitamin B6. [Accessed 12 Apr. 2019] (online) Available from:
  4. DailyMed. Pyridoxine hydrochloride. [Accessed 12 Apr. 2019] (online) Available from:
  5. doxylamine succinate and pyridoxine: Guadalajara, Spain: Exeltis healthcare S.L.; 2024 [Accessed 17 Jan. 2026] (online). Available from:
100% genuine products
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User feedback

Once A Day
91%
Twice A Day
9%
Others
50%
Morning sickness
50%
Average
57%
Poor
24%
Excellent
19%
Dryness in mouth
25%
Drowsiness
25%
Nausea
25%
No Side Effect
25%
With food
50%
With or without food
25%
Empty stomach
25%
Average
42%
Expensive
33%
Not Expensive
25%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Systopic Laboratories Pvt Ltd
Address: 101, Pragati Chambers, Commercial Complex, Ranjit Nagar, New Delhi-110008

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Sysfol Plus Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

Lab tests offered by us

Why we need a prescription?
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In accordance with the law
Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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