Donep-M Plus Tablet
Prescription RequiredProduct introduction
Donep-M Plus Tablet is a prescription medicine used to treat Alzheimer's disease. It helps to slow down the progression of moderate to severe Alzheimer's by improving memory and thinking. It also increases the levels of a chemical messenger involved in the transmission of nerve signals.
Donep-M Plus Tablet can be taken with or without food, but you may take it with food to avoid a stomach upset. However, it is advised to take it at the same time each day to maintain a consistent level of medicine in the blood. Do not skip any doses, but if you miss a dose of this medicine, take it as soon as you remember. Finish the full course of treatment even if you feel better and do not stop taking it suddenly.
Some common side effects of this medicine include nausea, vomiting, loss of appetite, fatigue, and headache. It may also cause dizziness and sleepiness. So, do not drive or do anything that requires mental focus until you know how this medicine affects you. Drink plenty of fluids to keep yourself hydrated while taking this medicine as this medicine may cause diarrhea.
Before using this medicine, you should tell your doctor if you have ever had heart problems, stomach ulcers, epilepsy or asthma. It may also affect, or be affected by, some other drugs you are using so let your doctor know what these are to be safe. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Uses of Donep-M Tablet
Side effects of Donep-M Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Donep-M
- Weight loss
- Drug allergy
- Balance disorder (loss of balance)
- High blood pressure
- Breathlessness
- Diarrhea
- Nausea
- Muscle cramp
- Dizziness
- Headache
- Insomnia (difficulty in sleeping)
How to use Donep-M Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Donep-M Plus Tablet may be taken with or without food.
How Donep-M Tablet works
Donep-M Plus Tablet is a combination of two medicines: Donepezil and Memantine which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor while Memantine is an NMDA inhibitor. Together, they balance the levels of chemical messengers in the brain and help in the transmission of nerve signals.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Donep-M Plus Tablet. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Donep-M Plus Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of Donep-M Plus Tablet during breastfeeding is not available. Please consult your doctor.
Driving
UNSAFE
Donep-M Plus Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Donep-M Plus Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver
CAUTION
Donep-M Plus Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
What if you forget to take Donep-M Tablet?
If you miss a dose of Donep-M Plus Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Donep-M Plus Tablet is used for the symptomatic treatment of alzheimer's disease. It does not cure alzheimer's, but may help with brain function and doing daily activities.
- Monitor your body weight regularly as both Donep-M Plus Tablet and alzheimer's disease can cause weight loss.
- Don't drive or do anything that requires mental focus until you know how it affects you.
- Inform your doctor if you have a history of seizures as it may raise the chances of seizure if you had them in the past.
- It may cause stomach ulcers, specially if you are also taking medications for inflammation or pain. Talk to your doctor if you vomit blood or have black colored stools.
Fact Box
Habit Forming
No
Therapeutic Class
NEURO CNS
Patient concerns
FAQs
What are the instructions for the storage and disposal of Donep-M Plus Tablet?
Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
What are the contraindications to the use of Donep-M Plus Tablet?
Donep-M Plus Tablet is contraindicated in patients who are allergic to Memantine, Donepezil or any of its constituents. Also, inform your doctor about all of patients medical history before using this medicine.
What should I inform my doctor before using Donep-M Plus Tablet?
Before taking Donep-M Plus Tablet, tell the doctor about all of patient's past and present medical conditions, including: problem in heart, lung, liver, kidney or bladder, seizures, stomach ulcers or any scheduled medical procedures. Also, inform your doctor about all the medicines patient takes.
What if the patient takes more of Donep-M Plus Tablet than recommended?
If the patient overdose on Donep-M Plus Tablet, go to nearest medical emergency department or call your doctor immediately.
Can the use of Donep-M Plus Tablet cause diarrhea?
Yes, the use of Donep-M Plus Tablet can cause diarrhea. In case, the patient experience diarrhea, talk to the doctor. Do not take any other medicines without speaking to a doctor.
What should I inform my doctor before using Donep-M Plus Tablet?
Before taking Donep-M Plus Tablet, tell the doctor about all of patient's past and present medical conditions, including: problem in heart, lung, liver, kidney or bladder, seizures, stomach ulcers or any scheduled medical procedures. Also, inform your doctor about all the medicines patient takes.
What if the patient takes more of Donep-M Plus Tablet than recommended?
If the patient overdose on Donep-M Plus Tablet, go to nearest medical emergency department or call your doctor immediately.
Can the use of Donep-M Plus Tablet cause diarrhea?
Yes, the use of Donep-M Plus Tablet can cause diarrhea. In case, the patient experience diarrhea, talk to the doctor. Do not take any other medicines without speaking to a doctor.
What are the instructions for the storage and disposal of Donep-M Plus Tablet?
Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.
What are the contraindications to the use of Donep-M Plus Tablet?
Donep-M Plus Tablet is contraindicated in patients who are allergic to Memantine, Donepezil or any of its constituents. Also, inform your doctor about all of patients medical history before using this medicine.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Memantine and Donepezil [Prescribing Information]. Princeton, NJ: Macleods Pharma USA, Inc.; 2025. [Accessed 03 Dec. 2025]. Available from:
Marketer details
Name: Alkem Laboratories Ltd
Address: Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Country of origin: India
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