Donepezil + Memantine

Last updated 03 Dec 2025 | 05:29 PM (UTC)

Donepezil + Memantine Uses

Donepezil+Memantine is used in the treatment of Alzheimer's disease.

How Donepezil + Memantine works

Donepezil + Memantine is a combination of two medicines: Donepezil and Memantine which treat Alzheimer’s disease. Donepezil is a cholinesterase inhibitor while Memantine is an NMDA inhibitor. Together, they balance the levels of chemical messengers in the brain and help in the transmission of nerve signals.

Common side effects of Donepezil + Memantine

Diarrhea, Dizziness, Headache, Nausea, Insomnia (difficulty in sleeping), Weight loss, Drug allergy, Balance disorder (loss of balance), High blood pressure, Breathlessness

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Medicine brands for Donepezil + Memantine

Donamem

Sun Pharmaceutical Industries Ltd

₹187 to ₹285

3 variant(s)

Alzil-M

Intas Pharmaceuticals Ltd

₹239 to ₹315

3 variant(s)

Aricep-M

Eisai Pharmaceuticals India Pvt Ltd

₹163 to ₹225

2 variant(s)

Larentine D

La Renon Healthcare Pvt Ltd

Alteus Biogenics Pvt Ltd

Cadila Pharmaceuticals Ltd

₹143 to ₹143

1 variant(s)

Expert advice for Donepezil + Memantine

Donepezil + Memantine is used for the symptomatic treatment of alzheimer's disease. It does not cure alzheimer's, but may help with brain function and doing daily activities.
Take it with food to avoid an upset stomach and drink plenty of fluids to keep yourself hydrated while taking this medicine.
Monitor your body weight regularly as both Donepezil + Memantine and alzheimer's disease can cause weight loss.
Don't drive or do anything that requires mental focus until you know how it affects you.
Inform your doctor if you have a history of seizures as it may raise the chances of seizure if you had them in the past.
It may cause stomach ulcers, specially if you are also taking medications for inflammation or pain. Talk to your doctor if you vomit blood or have black colored stools.

Frequently asked questions for Donepezil + Memantine

Q. What should I inform my doctor before using Donepezil+Memantine?

Before taking Donepezil+Memantine, tell the doctor about all of patient's past and present medical conditions, including: problem in heart, lung, liver, kidney or bladder, seizures, stomach ulcers or any scheduled medical procedures. Also, inform your doctor about all the medicines patient takes.

Q. What if the patient takes more of Donepezil+Memantine than recommended?

If the patient overdose on Donepezil+Memantine, go to nearest medical emergency department or call your doctor immediately.

Q. Can the use of Donepezil+Memantine cause diarrhea?

Yes, the use of Donepezil+Memantine can cause diarrhea. In case, the patient experience diarrhea, talk to the doctor. Do not take any other medicines without speaking to a doctor.

Q. What are the instructions for the storage and disposal of Donepezil+Memantine?

Keep this medicine in the packet or container it came in, tightly closed. Store it as mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children, and other people.

Q. What are the contraindications to the use of Donepezil+Memantine?

Donepezil+Memantine is contraindicated in patients who are allergic to Memantine, Donepezil or any of its constituents. Also, inform your doctor about all of patients medical history before using this medicine.