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Depofil Tablet

Written By Dr. Sakshi Jain, MS, BDS
Reviewed By Dr. Sachin Gupta, MD Pharmacology, MBBS
Last updated on 21 Jan 2026 | 04:51 PM (IST)
Depofil Tablet is a combination of two medicines used in the treatment of premature ejaculation in adult men. It increases blood flow to the penis to help men get an erection. This medicine should be used only when prescribed by a doctor.
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The content is shown in English
Depofil Tablet image
Depofil Tablet image

Product introduction

Depofil Tablet works by helping to relax the blood vessels in your penis, allowing blood to flow into your penis when you get sexually excited. It may be taken with or without food. Take it as advised by your doctor before having sexual activity.


Some common side effects of this medicine include nausea, vomiting, indigestion, headache, flushing (sense of warmth in the face, ears, neck, and trunk), nosebleeds, and dry mouth. It even causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you.

It should be used with caution in patients with a history of seizures, depression, and other psychiatric disorders. Before you take this medicine, let your doctor also know if you have any history of heart, kidney, or liver diseases.

Uses of Depofil Tablet

  • Treatment of Premature ejaculation

Benefits of Depofil Tablet

Treatment of Premature ejaculation
Depofil Tablet increases the level of a chemical called serotonin in the brain. This increases the time taken to ejaculate and improves control over ejaculation. This helps reduce any frustration or worry that you may have due to quick ejaculation and improves your confidence. It is usually taken 1 to 3 hours before sexual activity is anticipated. Do not take this medicine more than once a day.

Side effects of Depofil Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Depofil
  • Nausea
  • Vomiting
  • Flushing (sense of warmth in the face, ears, neck and trunk)
  • Indigestion
  • Headache
  • Dizziness
  • Nosebleeds
  • Dryness in mouth
  • Limb pain

How to use Depofil Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Depofil Tablet may be taken with or without food.

How Depofil Tablet works

Depofil Tablet is a combination of two medicines: Tadalafil and Dapoxetine, which treat premature ejaculation. Tadalafil is a phosphodiesterase type 5 (PDE5) inhibitor that works by increasing blood flow to the penis during sexual stimulation and enables its erection following sexual stimulation. Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that increases the level of serotonin in nerves to improve control over ejaculation and increase the time taken to ejaculate.

Quick tips

  • Take it 1 to 3 hours before anticipated sexual activity.
  • Do not take it more than once every 24 hours or every day.
  • Do not drive or do anything requiring concentration until you know how Depofil Tablet affects you.
  • It may cause a sudden drop in your blood pressure. Rise slowly if you have been sitting or lying down.
  • Inform your doctor if the erection persists for more than 4 hours after sexual intercourse.
  • Do not take Depofil Tablet if you have had a heart attack in the past 3 months, or stroke, or heart failure in the past 6 months.

Safety advice

Alcohol

Alcohol

UNSAFE
Do not drink alcohol while you are taking this medicine. Depofil Tablet may cause excessive drowsiness when taken with alcohol.
Pregnancy

Pregnancy

UNSAFE
Depofil Tablet is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Depofil Tablet may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

UNSAFE
Depofil Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Depofil Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver

Liver

UNSAFE
Depofil Tablet is unsafe to use in patients with liver disease and should be avoided.

Frequently asked questions

No, taking Depofil Tablet may make you feel sleepy and dizzy. So, do not drive or use machines while taking this medicine.
Before you start taking Depofil Tablet tell your doctor if you have or have had heart problems such as a heart attack, irregular heartbeat, angina, chest pain or had heart surgery within the last 6 months. Inform you doctor if you have low blood pressure or uncontrolled high blood pressure.
Yes, the use of Depofil Tablet can cause dry mouth. If you experience dry mouth, drink plenty of water. Take regular sips during the day and keep some water by your bed at night. You may use lip balm if your lips are also dry.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
It should be taken approximately 1 to 3 hours before a sexual activity is anticipated. The effect may last for almost 4-5 hours, which is enough to complete the actual intercourse and to treat erectile dysfunction in most men.

Fact Box

Habit Forming

No

Therapeutic Class

SEX STIMULANTS REJUVENATORS

References

  1. Tadalafil & Dapoxetine [Prescribing Information]. Dehradun, Uttarakhand: Coral Laboratories Ltd.
Related ayurvedic ingredients
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User feedback

Once A Day
96%
Once A Week
4%
Erectile dysfunction
50%
Others
50%
Poor
56%
Average
33%
Excellent
11%
Nausea
33%
Headache
33%
No Side Effect
17%
Dizziness
17%
With or without food
60%
With food
40%
Average
40%
Not Expensive
33%
Expensive
27%
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: R B Pharmaceuticals
Address: No. 13, Guruvappa Street, Old Washermenpet, Chennai - 600021, Tamil Nadu, India

Vendor Details

Country of origin: India
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