Product introduction
Defrab-D Capsule is a combination medicine used to treat gastroesophageal reflux disease (acid reflux). It works by relieving the symptoms of acidity, such as heartburn, stomach pain, or irritation. It also neutralizes the acid and promotes easy passage of gas to reduce stomach discomfort.
Defrab-D Capsule should be taken on an empty stomach in the dose and duration advised by your doctor. The exact dose will depend on your condition and response to treatment. Continue taking it for as long as prescribed, even if your symptoms improve, as stopping early may cause them to return or worsen. Inform your healthcare provider about all other medicines you are taking, as some may interact with Defrab-D Capsule.
Common side effects include diarrhea, stomach pain, headache, weakness and flatulence. These are usually mild and temporary. However, contact your doctor immediately if any side effects persist or cause concern. This medicine may cause dizziness or drowsiness, so avoid driving or activities requiring alertness until you know how it affects you.
Refrain from drinking alcohol, as it can increase drowsiness. Lifestyle measures such as drinking cold milk and avoiding spicy foods, coffee, tea, and chocolate can enhance treatment effectiveness. Before starting Defrab-D Capsule, inform your doctor if you have any liver or kidney problems, or if you are pregnant, planning to become pregnant, or breastfeeding.
Uses of Defrab-D Capsule
Benefits of Defrab-D Capsule
In Treatment of Gastroesophageal reflux disease (Acid reflux)
Gastroesophageal reflux disease (GERD) is a chronic (long-term) condition in which there is an excess production of acid in the stomach. Defrab-D Capsule reduces the amount of acid your stomach makes and relieves the pain associated with heartburn and acid reflux. You should take it exactly as it is prescribed for it to be effective. Some simple lifestyle changes can help reduce the symptoms of GERD. Think about what foods trigger heartburn and try to avoid them; eat smaller, more frequent meals; try to lose weight if you are overweight, and try to find ways to relax. Do not eat within 3-4 hours of going to bed.
Side effects of Defrab-D Capsule
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Defrab-D
- Flatulence
- Back pain
- Cough
- Headache
- Diarrhea
- Dizziness
- Inflammation of the nose
- Abdominal pain
- Vomiting
- Insomnia (difficulty in sleeping)
- Nausea
- Constipation
- Nasal congestion (stuffy nose)
- Fundic gland polyps
How to use Defrab-D Capsule
Take this medicine in the dose and duration as advised by your doctor. Defrab-D Capsule is to be taken on an empty stomach.
How Defrab-D Capsule works
Defrab-D Capsule is a combination of two medicines: Domperidone and Rabeprazole. Domperidone is a prokinetic which works on the upper digestive tract to increase the movement of the stomach and intestines, allowing the food to move more easily through the stomach. Rabeprazole is a proton pump inhibitor (PPI) which works by reducing the amount of acid in the stomach, which helps in the relief of acid-related indigestion and heartburn.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Defrab-D Capsule. Please consult your doctor.
Pregnancy
UNSAFE
Defrab-D Capsule is highly unsafe during pregnancy. It can cause serious harm to the unborn baby, including birth defects and pregnancy loss. Do not use this medicine if you are pregnant or planning to become pregnant.
Breast feeding
UNSAFE
Defrab-D Capsule is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.
Driving
UNSAFE
Defrab-D Capsule may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney
CAUTION
Defrab-D Capsule should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.
Liver
UNSAFE
Defrab-D Capsule is unsafe to use in patients with liver disease and should be avoided.
Use of Defrab-D Capsule is not recommended in patients with moderate and severe liver disease.
Use of Defrab-D Capsule is not recommended in patients with moderate and severe liver disease.
What if you forget to take Defrab-D Capsule?
If you miss a dose of Defrab-D Capsule, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
Defrab-D Capsule
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Quick tips
- Take Defrab-D Capsule one hour before the meal, preferably in the morning.
- It is a well-tolerated medicine and provides relief for a long time.
- Inform your doctor if you experience watery diarrhea, fever, or stomach pain that persists.
- Inform your doctor if you do not feel better after taking it for 14 days, as you may be suffering from some other problem that needs attention.
- Long-term use can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor.
Fact Box
Habit Forming
No
Therapeutic Class
GASTRO INTESTINAL
Patient concerns
User feedback
How much was the improvement?
Excellent
67%
Average
33%
FAQs
What is Defrab-D Capsule?
Defrab-D Capsule is a combination of two medicines: Domperidone and Rabeprazole. This combination is used to treat acidity and heartburn or gastroesophageal reflux disease (GERD); a condition where the acid in the stomach flows back up into the food pipe (esophagus). It is also used to treat gastric and duodenal ulcers. Domperidone helps to control vomiting by increasing the movement of the gut, allowing the food to move more easily through the stomach.
What are the contraindications of Defrab-D Capsule?
The use of Defrab-D Capsule is considered to be harmful for patients with a known hypersensitivity to rabeprazole or domperidone or any other inactive ingredients of the medicine. Caution is advised in patients with underlying kidney or liver disease.
Can the use of Defrab-D Capsule cause dry mouth?
Yes, the use of Defrab-D Capsule can cause dry mouth. Dryness of mouth occurs due to Domperidone. If you experience dry mouth, drink plenty of water. Keep some water on your bedside at night. Cut down the intake of alcohol and avoid smoking. If you have dry mouth, try to use alcohol-free mouthwash as its use can increase the risk of tooth decay.
Can the use of Defrab-D Capsule cause diarrhea?
Yes, the use of Defrab-D Capsule can cause diarrhea. In case you experience diarrhea, drink plenty of water or other fluids. Avoid taking fatty or fried foods along with this medication. Talk to your doctor if diarrhea persists and if you notice any signs of dehydration, like less urination with dark colored and strong-smelling urine.
What is the recommended storage condition for Defrab-D Capsule?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Is it safe to use Defrab-D Capsule?
Yes, Defrab-D Capsule is safe for most of the patients. However, in some patients it may cause common side effects like diarrhea, stomach pain, flatulence, dryness in mouth, dizziness, headache and other uncommon and rare side effects. Inform your doctor if you experience any persistent problem while taking this medicine.
What is the best time to take Defrab-D Capsule?
It is best to take Defrab-D Capsule before the first meal of the day or on an empty stomach.
Can the use of Defrab-D Capsule cause abnormal heartbeat?
Yes, the use of Defrab-D Capsule can increase the risk of developing irregular heartbeat (serious arrhythmias). This is a serious side effect but the chance that it may happen is very low. The risk may be slightly higher in those who are more than 60 years of age.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- CiplaMed. Rabeprazole sodium + Domperidone [Prescribing Information]. Mumbai, India: Cipla Ltd.; 2020. [Accessed 13 May 2021] (online) Available from:
- Rabeprazole (GR) and Domperidone (SR) Capsules [Drug Label]. Haridwar, Uttarakhand: Pure & Cure Healthcare Pvt. Ltd.; 2023. [Accessed 13 May 2021] (online) Available from:
- Rabeprazole sodium and Domperidone sustained release capsules [Patient Information Sheet]. Solan, Himachal Pradesh: Torrent Pharmaceuticals Ltd.; 2022. [Accessed 13 May 2021] (online) Available from:
- Rabeprazole. Mumbai, Maharashtra: J.B. Chemicals and Pharmaceuticals Ltd.; 2025. [Accessed 17 Feb 2026] (online). Available from:
Marketer details
Name: Deify Pharma
Address: PLOT NO 40, ANANDNAGAR COLONY CHINNA THOKATTA BOWENPALLY, SECUNDERABAD SECUNDERABAD TG 500011 IN , - , .
Country of origin: India
Expires on or after: May, 2026
A licensed vendor partner from your nearest location will deliver Defrab-D Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: May, 2026
A licensed vendor partner from your nearest location will deliver Defrab-D Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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MRP₹112.5
₹112
Inclusive of all taxes
10.0 capsules in 1 strip
The price displayed is the MRP (inclusive of applicable taxes). Any additional fee (such as shipping fee, handling and/or platform fee etc.) will be clearly disclosed before you complete your purchase.
Get by Wednesday, 25 February
Delivering to:
