Darzalex Injection
Prescription RequiredProduct introduction
Darzalex Injection is used in the treatment of multiple myeloma, which is a type of cancer of plasma cells.
Darzalex Injection is given as an IV infusion into veins under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
Infusion reaction such as swollen face, lips, mouth, tongue or throat, difficulty swallowing or breathing are very common side effects. This medicine may reduce the number of blood cells (decrease white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells while taking this medicine.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. Use of effective contraception by both males and females during treatment is important to avoid pregnancy.
There is a Patient Support Program/Patient Assistance Program available in India for this medicine, being managed by Tata 1mg. Please contact your prescribing doctor to know more about the same. You may also call on (1800-102-1618) for more details.
Uses of Darzalex Injection
Benefits of Darzalex Injection
In Treatment of Multiple myeloma
Multiple myeloma is a type of blood cancer that affects plasma cells in the bone marrow, leading to weak bones, anemia, kidney problems, and frequent infections. Darzalex Injection helps control the growth of these cancerous cells, improving symptoms, slowing disease progression, and enhancing quality of life.
Side effects of Darzalex Injection
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Darzalex
- Gastrointestinal toxicity
- Headache
- Decreased appetite
- Joint inflammation
- Chest pain
- Decreased potassium level in blood
- Weakness
- Infection
- Muscle spasm
- Insomnia (difficulty in sleeping)
- Peripheral edema
- Infusion reaction
- Altered blood cell count
- Respiratory tract infection
- Increased liver enzymes
- Fatigue
- Back pain
How to use Darzalex Injection
Your doctor or nurse will give you this medicine. Kindly do not self administer.
How Darzalex Injection works
Darzalex Injection is a monoclonal antibodies, which are designed to recognise and attach to specific proteins on the surface of cancer cells. It shows its action by binding to specific cancer cells in the body and helps your immune system kills cancer.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Darzalex Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
The safety of Darzalex Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding
CONSULT YOUR DOCTOR
Darzalex Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving
SAFE
Darzalex Injection does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Darzalex Injection is probably safe to use in patients with kidney disease. Limited data suggest dose adjustment may not be needed.
Liver
SAFE IF PRESCRIBED
Darzalex Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.
What if you forget to take Darzalex Injection?
If you miss a dose of Darzalex Injection, please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- Darzalex Injection is given in combination with other medicines for the treatment of multiple myeloma.
- Drink at least two to three quarts of fluid every 24 hours while on treatment with Darzalex Injection, unless you are instructed otherwise.
- To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
- Avoid sun exposure. Wear SPF 30 (or higher) sunblock and protective clothing.
- Do not receive any kind of immunization or vaccination without your doctor's approval while taking Darzalex Injection.
- Use contraceptives, and avoid getting pregnant while taking Darzalex Injection. Barrier methods of contraception, such as condoms, should be used during treatment and for 3 months after the last dose of Darzalex Injection.
- Before receiving Darzalex Injection inform your doctor if you have a history of breathing problems or hepatitis B infection.
- Let your doctor know if you are pregnant or plan to become pregnant or breastfeeding.
Fact Box
Chemical Class
Peptides
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Patient concerns
FAQs
What is Darzalex Injection used for?
Darzalex Injection is prescribed for adults with multiple myeloma (a type of cancer of plasma cells) and may be given alone or with other medicines, depending on the treatment plan and prior therapies.
What are the most important infusion-related warnings of Darzalex Injection?
Infusion reactions due to Darzalex Injection can be serious or life-threatening, especially during the first doses, causing trouble breathing, wheezing, chest discomfort, fast heartbeat, blood pressure changes, swelling, severe headache, or vision changes. Infusions are slowed, paused, or stopped, and emergency care is given if reactions occur.
Can Darzalex Injection affect blood transfusions or blood tests?
Yes, Darzalex Injection can cause a positive indirect Coombs test and interfere with matching blood for transfusions for up to six months after the last dose, so a blood type and screen is done before starting this medicine, and blood banks must be informed about current or recent treatment.
Does Darzalex Injection lower blood counts?
Darzalex Injection can reduce white blood cells (raising infection risk) and platelets (raising bleeding risk), so regular blood tests are done, and dosing may be delayed until counts recover when needed.
Can hepatitis B reactivate with Darzalex Injection?
Yes, hepatitis B can reactivate with Darzalex Injection, rarely causing severe illness. Doctors check hepatitis B status before, during, and after treatment and monitor for symptoms such as worsening tiredness or yellowing of eyes/skin.
Does Darzalex Injection change how doctors measure myeloma response?
Yes, Darzalex Injection can appear on serum protein tests (SPEP/IFE) and look like the myeloma protein, potentially masking a complete response. Specialized assays may be used to distinguish the medicine from the disease protein when needed.
Are there special cautions for breathing or eye symptoms during receiving Darzalex Injection?
People with chronic lung disease may need extra inhaled medicines in addition to receiving Darzalex Injection. Additionally, any new eye pain, blurred vision, or acute vision changes during receiving Darzalex Injection should trigger an immediate pause and urgent eye evaluation before restarting.
What should be done before starting Darzalex Injection treatment to improve safety?
Before starting Darzalex Injection, your doctor will check your blood type and hepatitis B status, plan medicines to prevent infusion reactions, and arrange regular blood count monitoring. You should also inform your doctor about any past infections, lung problems, and all medicines or supplements you’re taking.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Janssen Biotech, Inc. Darzalex (Daratumumab). [Accessed 29 Oct. 2019] (online) Available from:
- Daratumumab [FDA Label]. Horsham, PA: Janssen Biotech, Inc.; 2015 [revised Jun. 2019]. [Accessed 29 Oct. 2019] (online) Available from:
Marketer details
Name: Janssen Pharmaceuticals
Address: Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Country of origin: United kingdom
Expires on or after: February, 2026
A licensed vendor partner from your nearest location will deliver Darzalex Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
Expires on or after: February, 2026
A licensed vendor partner from your nearest location will deliver Darzalex Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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₹16252
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5.0 ml in 1 vial
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