Comvac 4 HB Injection

Diphtheria Toxoid (20LF)+ Tetanus Toxoid (5LF)+ Pertussis Toxoid (15OU)+ Hepatitis B Vaccine (rDNA) (10mcg)+ Aluminium Hydroxide (0.3mg)

Genuine

Authenticity Assured

Prescription

required

Cold stored

Stored between 2-8°C

Comvac 4 HB Injection is a combination medicine used to prevent diphtheria, tetanus, pertussis and chronic hepatitis B virus (HBV) infection. It helps in developing immunity by initiating a mild infection. It helps the immune system to produce antibodies (proteins) to protect against any future infections.

Written By Dr. Syeda Aafia, MBA, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 07 Apr 2026 | 10:23 AM (IST)

₹104 MRP ₹117.1911% off

Gurgaon

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General Information

Contains

Diphtheria Toxoid (20LF)+ Tetanus Toxoid (5LF)+ Pertussis Toxoid (15OU)+ Hepatitis B Vaccine (rDNA) (10mcg)+ Aluminium Hydroxide (0.3mg)

Marketer

Bharat Biotech

Storage

Store in a refrigerator (2 - 8°C). Do not freeze.

The content is shown in English

Product introduction

Comvac 4 HB Injection should be injected by a doctor or healthcare professional. It is given via muscle in the anterolateral region of the thigh of infants and young children. You should not take it if you have any known allergy from this injection. Do not skip any doses and follow your doctor’s instructions carefully to get maximum benefit.

The most common side effects include redness at the injection site, tenderness, irritability, vomiting, loss of appetite and fever. If any of these side effects or any other symptoms which you think are because of this medicine persist for a longer duration, please inform your doctor.

Uses of Comvac 4 HB Injection

Benefits of Comvac 4 HB Injection

Prevention of Hepatitis B virus (HBV) infection
Hepatitis B is an infection of the liver caused by the Hepatitis B virus (HBV). When the infection moves into a long-lasting stage, it is called chronic hepatitis B virus infection. It can spread from person to person through blood, semen or other body fluids. Hepatitis B can cause mild illness lasting a few weeks, or it can lead to a serious, lifelong illness. Comvac 4 HB Injection is given to prevent hepatitis B infection. It is recommended for all infants and children of 6 weeks through 6 years of age. Hoever, it is advisable to consult your doctor for complete information regarding vaccination schedules.

Prevention of Tetanus
Tetanus is a serious bacterial infection that affects the nervous system and causes muscles throughout the body to become stiff and tighten. Comvac 4 HB Injection helps prevent tetanus infection. It helps the immune system to produce antibodies to fight against tetanus infection. However, it does not provide lifelong protection. Children need to get a booster shot at 11 or 12 years of age. Adults need a booster shot every 10 years after that. It is advisable to consult your doctor for complete information regarding vaccination schedules.

Prevention of Pertussis
Pertussis (often called whooping cough) is an infection of the airways that can occur at any age but mostly affects infants and young children. The infection causes uncontrollable coughing that can make it difficult to breathe. Comvac 4 HB Injection gives protection from pertussis. Infants and children need a dose of the vaccine starting at 2 months through 6 years. However, it is advisable to consult your doctor for complete information regarding vaccination schedules.

Prevention of Diphtheria
Diphtheria is a bacterial infection that causes pain and swelling in the throat. This might cause difficulty in breathing. It might also damage the heart, kidneys and nerves. Comvac 4 HB Injection gives protection against diphtheria. It is recommended to get your child vaccinated against diphtheria starting at 6 weeks through 6 years. It is advisable to consult your doctor for complete information regarding vaccination schedules.

Side effects of Comvac 4 HB Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Comvac 4 HB

Injection site reactions (pain, swelling, redness)
Headache
Body ache
Muscle weakness
Tiredness
Joint pain
Feeling of discomfort

How to use Comvac 4 HB Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Comvac 4 HB Injection works

Comvac 4 HB Injection is a combination of four medicines. Diphtheria Toxoid, Tetanus Toxoid, Pertussis Toxoid, and Hepatitis B Vaccine (rDNA) are vaccines (inactivated microorganisms) that are formulated together to develop immunity by initiating a mild infection. This type of infection does not cause illness but stimulates the body's immune system to produce antibodies (proteins) to protect against any future infections. Aluminium Hydroxide is an adjuvant that helps to potentiate the action of the vaccine in the body by increasing its uptake. This is how it works to prevent various viral and bacterial infections.

Quick tips

Comvac 4 HB Injection helps to protect your child against diphtheria, tetanus, pertussis (whooping cough), and Hepatitis caused by Hepatitis-B virus.
Comvac 4 HB Injection should not be given to infants or children with fever or other evidence of acute illness or infection.
It is important to tell your doctor, if there is a personal or family history of central nervous system disease or convulsions.
Comvac 4 HB Injection should not be given to children over six years of age or to adults.
Please tell your doctor if your child is taking or has recently taken any other medicines, including medicines obtained without a prescription.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Comvac 4 HB Injection. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Comvac 4 HB Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding

SAFE IF PRESCRIBED

Comvac 4 HB Injection may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Driving

NOT RELEVANT

Not relevant, as Comvac 4 HB Injection is intended for use in hospitalized patients.

Kidney

CAUTION

Comvac 4 HB Injection should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

SAFE IF PRESCRIBED

Comvac 4 HB Injection is probably safe to use in patients with liver disease. Limited data suggest dose adjustment may not be needed.

Fact Box

Habit Forming

Therapeutic Class

VACCINES

Related lab tests

Complete Blood Count

Hepatitis B (Core) IgM Antibody

Hepatitis B s (Surface) Antigen

Hepatitis C Virus Total Antibody

References

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Bharat Biotech
Address: Genome Valley, Shameerpet, Hyderabad – 500 078 Telagana INDIA

Vendor Details

Country of origin: India

Lab tests offered by us

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