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Comig 500 Tablet

Naproxen (500mg)+ Domperidone (10mg)

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Comig 500 Tablet is a medicine used in the prevention of migraines. It inhibits the release of certain chemical messengers that cause pain, inflammation, and fever. It also blocks the signals in the brain that cause nausea and vomiting associated with migraines.

Written By Dr. Anuj Saini, MMST, MBBS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 09 Apr 2026 | 06:57 PM (IST)

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General Information

Contains

Naproxen (500mg)+ Domperidone (10mg)

Marketer

Seagull Pharmaceutical Pvt Ltd

Storage

Store below 30°C

The content is shown in English

Product introduction

Comig 500 Tablet may be prescribed alone or in combination with another medicine. It can be taken with or without food. The dose and duration will depend on the severity of your condition and how well it helps your symptoms. Use it regularly and do not discontinue it until the doctor tells you it is right to stop.

Using Comig 500 Tablet may cause common side effects such as headaches, ringing in the ears, dizziness, tiredness, rashes, and vision changes. If you experience such side effects that do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the symptoms.

In general, you should try to use the smallest amount necessary to control your symptoms. Before using the medicine, you should tell your doctor if you have any other illnesses or disorders. It may also affect, or be affected by, some other medicines you are using, so let your doctor know all the other medicines you are taking. Pregnant and breastfeeding women should consult their doctors first before using the medicine.

Uses of Comig Tablet

Prevention of Migraine : Comig 500 Tablet helps prevent migraine, reducing symptoms like throbbing head pain, nausea, and sensitivity to light or sound.

Benefits of Comig Tablet

Prevention of Migraine
Migraine is a recurring condition that causes severe headaches along with nausea and vomiting. Comig 500 Tablet works by blocking chemicals responsible for pain sensation and signals that trigger nausea and vomiting during migraine attacks. This helps prevent migraine attacks, reduce their frequency, and relieve associated symptoms.

Side effects of Comig Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Comig

Dryness in mouth
Ringing in ear
Altered vision
Tiredness
Dizziness
Drowsiness
Rash

How to use Comig Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Comig 500 Tablet may be taken with or without food.

How Comig Tablet works

Comig 500 Tablet is a combination of two medicines: naproxen and domperidone. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that works by blocking the release of certain chemical messengers that cause migraine pain. Domperidone works on the part of the brain that controls nausea and vomiting associated with migraine. Together, these medicines help relieve migraine symptoms.

All substitutes for Comig 500 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

Take Comig 500 Tablet exactly as prescribed. Do not take more than the recommended dose.
Avoid alcohol while taking Comig 500 Tablet, as it may increase dizziness and the risk of stomach bleeding.
Comig 500 Tablet may cause dizziness, so avoid driving or operating machinery until you know how it affects you.
Do not take Comig 500 Tablet with other NSAID painkillers unless advised by your doctor.
Inform your doctor if you have a history of stomach ulcers, acid reflux, heart disease, kidney disease, asthma, or high blood pressure.
Stop taking Comig 500 Tablet and seek urgent medical help if you have black stools, vomit blood, severe stomach pain, chest pain, or swelling of the face or lips.
Seek medical advice if you experience palpitations, fainting, or severe dizziness, as domperidone may affect heart rhythm in some people.
Stay well hydrated and eat light meals if you experience nausea.
Avoid common migraine triggers such as bright light, loud noise, missed meals, alcohol, and foods that can trigger your headaches.
Consult your doctor if headaches become frequent or severe despite using Comig 500 Tablet.

Safety advice

Alcohol

UNSAFE

It is unsafe to consume alcohol with Comig 500 Tablet

Pregnancy

CONSULT YOUR DOCTOR

Comig 500 Tablet is not recommended during pregnancy as there is positive evidence of fetal risk based on animal studies. However, it may still be prescribed by a doctor in situations where the benefits outweigh the risks.

Breast feeding

CAUTION

Comig 500 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving

UNSAFE

Comig 500 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Comig 500 Tablet may make you feel dizzy, depressed, sleepy, tired, or make it difficult to sleep. It may also affect your vision. This may affect your driving ability.

Kidney

CAUTION

Comig 500 Tablet should be used with caution in patients with severe kidney disease. Dose adjustment may be needed.

Liver

UNSAFE

Comig 500 Tablet is unsafe to use in patients with liver disease and should be avoided.
Use of Comig 500 Tablet is not recommended in patients with moderate and severe liver disease.

Frequently asked questions

What is Comig 500 Tablet and what is it used for?

Comig 500 Tablet is used to treat migraine headaches, especially when they are associated with nausea or vomiting. It helps reduce migraine symptoms such as head pain, nausea, vomiting, and sensitivity to light or sound. The medicine works by blocking certain chemical signals in the body that cause pain and inflammation, while also helping control nausea associated with migraines. It should be taken only as prescribed by a doctor and not used regularly for other types of headaches without medical advice.

How should I take Comig 500 Tablet?

Take Comig 500 Tablet exactly as prescribed by your doctor. Swallow the tablet whole with water and do not crush or chew it. It may be taken with or without food, but taking it at the same time each day helps maintain consistent effects. If it causes stomach discomfort, taking it after food may help. Do not change the dose or schedule on your own. Consult your doctor if you miss doses often or if symptoms persist.

What are the side effects of Comig 500 Tablet?

Common side effects of Comig 500 Tablet may include headache, dizziness, tiredness, ringing in the ears, skin rash, or mild vision changes. Some people may also experience stomach discomfort or nausea. These effects are usually mild and may improve as the body adjusts to the medicine. However, consult your doctor if side effects persist, worsen, or become bothersome. Consult your doctor immediately if you have black stools, vomit blood, or severe stomach pain.

Can I drink alcohol while taking Comig 500 Tablet?

It is not recommended to drink alcohol while taking Comig 500 Tablet. Alcohol may increase dizziness and the risk of stomach irritation or bleeding. It may also make it harder to notice unwanted reactions from the medicine. Since the body is already dealing with migraine symptoms, alcohol may worsen discomfort or dehydration. For safety, avoid alcohol during treatment and consult your doctor if you have concerns.

Who should avoid taking Comig 500 Tablet?

Comig 500 Tablet should be used with caution and only under a doctor’s advice in people who are pregnant, have kidney or liver disease, heart problems, or high blood pressure. It may not be suitable during pregnancy unless clearly prescribed. Breastfeeding mothers should also consult a doctor before using it. Extra care is needed if you take other medicines or have ongoing health conditions. Always share your full medical history with your doctor before starting Comig 500 Tablet.

Can Comig 500 Tablet affect driving ability?

Comig 500 Tablet may cause dizziness, sleepiness, tiredness, or vision problems in some people. These effects can reduce alertness and may affect your ability to drive or operate machinery safely. If you feel dizzy, unusually tired, or notice vision changes after taking the medicine, avoid driving or using heavy machines until you feel normal again. Consult your doctor if these symptoms persist.

Can I take Comig 500 Tablet every day?

Comig 500 Tablet should only be used in the dose and duration recommended by your doctor. It is generally taken when migraine symptoms occur or as directed for prevention, and should not be used more frequently or in higher doses than prescribed. If your headaches become frequent or severe, consult your doctor rather than increasing the dose yourself. Repeated or excessive use may worsen headaches over time. Seek urgent medical care if symptoms such as severe weakness, fainting, chest pain, breathing difficulty, seizures, confusion, black stools, or severe dehydration occur.

How many times a day can Comig 500 Tablet be taken?

The number of times you should take Comig 500 Tablet depends on your doctor’s instructions and your medical condition. Always follow the dosing schedule provided by your doctor and do not increase the frequency on your own. Taking more than recommended may increase the risk of side effects. If the medicine upsets your stomach, your doctor may advise taking it after food and maintaining good hydration.

Fact Box

Habit Forming

Therapeutic Class

NEURO CNS

References

User feedback

Patients taking Comig 500 Tablet

Once A Day

58%

Twice A Day

42%

What are you using Comig Tablet for?

Migraine

45%

Headache

27%

Others

27%

How much was the improvement?

Excellent

42%

Average

38%

Poor

21%

What were the side-effects while using Comig 500 Tablet?

No Side Effect

57%

Dryness in mouth

29%

Indigestion

14%

How do you take Comig Tablet?

With or without food

50%

With food

33%

Empty stomach

17%

Please rate Comig 500 Tablet on price

Expensive

50%

Average

33%

Not Expensive

17%

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Seagull Pharmaceutical Pvt Ltd
Address: 305-307, Ansal Imperial Tower, C Block Community Centre, Naraina Vihar, New Delhi-110028, India

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Comig 500 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Comig 500 Tablet

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General Information

Contains

Marketer

Storage

Product introduction

Uses of Comig Tablet

Benefits of Comig Tablet

Side effects of Comig Tablet

How to use Comig Tablet

How Comig Tablet works

All substitutes for Comig 500 Tablet

Naprowel Forte 500mg/10mg Tablet

Napra D 500 Tablet

Minado 500 Tablet

Macprox DP 500 Tablet

Xenadom 500 Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Comig 500 Tablet and what is it used for?

How should I take Comig 500 Tablet?

What are the side effects of Comig 500 Tablet?

Can I drink alcohol while taking Comig 500 Tablet?

Who should avoid taking Comig 500 Tablet?

Can Comig 500 Tablet affect driving ability?

Can I take Comig 500 Tablet every day?

How many times a day can Comig 500 Tablet be taken?

Fact Box

Habit Forming

Therapeutic Class

References

User feedback

Patients taking Comig 500 Tablet

What are you using Comig Tablet for?

How much was the improvement?

What were the side-effects while using Comig 500 Tablet?

How do you take Comig Tablet?

Please rate Comig 500 Tablet on price

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

In case of any issues, contact us

Lab tests offered by us

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