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Colibest Tablet is a combination medicine used in the treatment of abdominal pain. It works effectively to reduce abdominal pain, bloating, discomfort and cramps by relaxing the muscles of the stomach and gut. It also blocks certain chemical messengers that cause pain, inflammation and fever.

Written By Dr. Subita Alagh, BDS,
Reviewed By Dr. Lalit Kanodia, MBA, MD Pharmacology,
Last updated on 19 Sep 2025 | 03:30 PM (IST)
₹52.2 MRP ₹57.6910% off 
 
 
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Colibest Tablet image
Colibest Tablet image

Product introduction

Colibest Tablet is taken with food in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should keep taking this medicine for as long as your doctor recommends. If you stop treatment too early your symptoms may come back and your condition may worsen. Let your healthcare team know about all other medications you are taking as some may affect, or be affected by this medicine.

The most common side effects are diarrhea, nausea, vomiting, dryness in the mouth, feeling thirsty, and increased liver enzymes. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your dizziness.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy or breastfeeding. You should also tell your doctor if you have any kidney or liver diseases so that your doctor can prescribe a suitable dose for you.


Note: As per the Ministry of Health and Family Welfare, Colibest Tablet is banned for children under 12 years of age.

Uses of Colibest Tablet

Benefits of Colibest Tablet

Abdominal pain
Colibest Tablet is a combination medicine which is used to relieve abdominal pain, especially when caused by muscle spasms or inflammation. It helps relax the abdominal muscles and reduces pain and swelling, providing quick and effective relief.

Side effects of Colibest Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Colibest
  • Vomiting
  • Dryness in mouth
  • Nausea
  • Vertigo
  • Insomnia (difficulty in sleeping)
  • Hypotension (low blood pressure)
  • Sweating
  • Constipation

How to use Colibest Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Colibest Tablet is to be taken with food.

How Colibest Tablet works

Colibest Tablet is a combination of two medicines: Drotaverine and Nimesulide, which relieves abdominal pain. Drotaverine is an anti-spasmodic medicine which relieves spasms associated with smooth muscles. Nimesulide is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).

All substitutes for Colibest Tablet

For information purposes only. Consult a doctor before taking any medicine.

Quick tips

  • You have been prescribed Colibest Tablet to get relief from abdominal pain.
  • Colibest Tablet should be taken with, or straight after, a meal or snack. This helps to reduce the risk of stomach upset.
  • Stick to simple meals and avoid spicy rich food in order to avoid feeling sick (nausea).
  • Drink plenty of water while taking Colibest Tablet in case you experience diarrhea as its side-effect.
  • Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help.
  • If you develop any new symptoms, or if your symptoms get worse, make an appointment to see your doctor for further advice.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with Colibest Tablet.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
Colibest Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Colibest Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
Colibest Tablet may cause side effects which could affect your ability to drive.
As Colibest Tablet may cause vertigo.
Kidney

Kidney

CAUTION
Colibest Tablet should be used with caution in patients with kidney disease. Dose adjustment of Colibest Tablet may be needed. Please consult your doctor.
Use of Colibest Tablet is not recommended in patients with severe kidney disease.
Liver

Liver

UNSAFE
Colibest Tablet is probably unsafe to use in patients with liver disease and should be avoided. Please consult your doctor.

Frequently asked questions

Colibest Tablet is usually used for short term and can be discontinued if there is no pain. However, it should be continued if your doctor told you to do so.
Colibest Tablet contains nimesulide. This medicine is known to cause harm to the liver especially in the doses above the recommended level. Avoid drinking alcohol while taking this medicine, as it may further increase your risk of liver damage. Use of this medicine should preferably be avoided in patients with underlying liver disease. Contact your doctor immediately if you notice any early signs and symptoms of liver damage. The symptoms may include fever, rash, loss of appetite, nausea, vomiting, fatigue, stomach pain, dark urine, yellow skin or eyes, and abnormal liver enzymes.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Colibest Tablet is usually used for short term and can be discontinued if there is no pain. However, it should be continued if your doctor told you to do so.
Colibest Tablet contains nimesulide. This medicine is known to cause harm to the liver especially in the doses above the recommended level. Avoid drinking alcohol while taking this medicine, as it may further increase your risk of liver damage. Use of this medicine should preferably be avoided in patients with underlying liver disease. Contact your doctor immediately if you notice any early signs and symptoms of liver damage. The symptoms may include fever, rash, loss of appetite, nausea, vomiting, fatigue, stomach pain, dark urine, yellow skin or eyes, and abnormal liver enzymes.
Keep this medicine in the packet or the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.

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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: BestoChem Formulations India Ltd
Address: G-54 3rd FLOOR LAXMI NAGAR VIKAS MARG DELHI -110092

Vendor Details

Country of origin: India
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