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Clos Cream

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 17 Jan 2026 | 02:57 AM (IST)
Clos Cream belongs to a group of medicines called steroids. It is used to treat various skin conditions such as dermatitis, eczema, and allergies. It works by reducing swelling, redness, and itchiness of the skin and prevents further irritation.
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Clos Cream is currently sold out
Same composition alternative:
TerABEt Cream
₹52.8₹58.13
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Clos Cream
Clos Cream
tube of 30 gm Cream
₹66.8
₹73.13
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Same composition
TerABEt Cream
TerABEt Cream
tube of 20 gm Cream
Clobetasol (0.05% w/w)
by Leeford Healthcare Ltd
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₹52.8
₹2.25 per gm

₹44.9

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₹1200

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General Information

Contains

Clobetasol (0.05% w/w)

Marketer

Syswin Pharmaceuticals Pvt Ltd

Storage

Store below 30°C
The content is shown in English
Clos Cream image
Clos Cream image

Product introduction

Clos Cream is meant for external use and is to be used only as advised by your doctor. Wash and dry the affected area before applying a thin layer of the medicine. Avoid any contact with your eyes, nose, or mouth. Rinse it off with plenty of water if you accidentally get it in these areas.


Common side effects include a feeling of burning, pain, irritation or itching at the site of application. These are usually temporary and usually resolve with time. However, if they persist or worsen, let your doctor know.


Avoid covering the treated area with airtight dressings such as bandages unless directed by a doctor. Clos Cream is not recommended to be used in children. Pregnant and breastfeeding mothers should also consult their doctors before using this medicine.

Uses of Clos Cream

Benefits of Clos Cream

Treatment of Allergic skin conditions
Clos Cream is effective in treating allergic skin conditions with inflammation and itching such as eczema and dermatitis. It helps reduce the redness, rash, pain, or itchiness caused by your skin’s reaction to an irritant. You should always use it as prescribed and only apply the amount you have been told to. Keep using it for as long as it is prescribed to get the full benefits.

Side effects of Clos Cream

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Clos
  • Application site reactions (burning, irritation, itching and redness)

How to use Clos Cream

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the cream. Wash your hands after applying, unless hands are the affected area.

How Clos Cream works

Clos Cream is a steroid. It works by blocking the production of certain chemical messengers that make the skin red, swollen and itchy.

All substitutes for Clos Cream

For information purposes only. Consult a doctor before taking any medicine.

TerABEt Cream

by Leeford Healthcare Ltd
₹2.64/gm of cream
18% costlier
<h3 class=bodySemiBold>TerABEt Cream</h3>

TENOvate Cream

by Glaxo SmithKline Pharmaceuticals Ltd
₹4.9/gm of cream
120% costlier
<h3 class=bodySemiBold>TENOvate Cream</h3>

Lobate Cream

by Abbott
₹7.67/gm of cream
244% costlier
<h3 class=bodySemiBold>Lobate Cream</h3>

Topinate Cream

by Systopic Laboratories Pvt Ltd
₹2.28/gm of cream
2% costlier
<h3 class=bodySemiBold>Topinate Cream</h3>

Clop Cream

by Zydus Cadila
₹5.73/gm of cream
157% costlier
<h3 class=bodySemiBold>Clop Cream</h3>

Quick tips

  • Clos Cream is used to treat redness, swelling, itching, and discomfort of various skin conditions.
  • It should be applied to the affected areas as a thin film two or three times daily, or as advised by your doctor.
  • Don't use it more often or for longer than advised by your doctor.
  • Don't cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
  • If you think the area of skin you are treating has become infected you should stop using Clos Cream and consult your doctor.
  • Consult your doctor if your skin condition has not improved after four weeks of treatment. Do not use it for more than 4 consecutive weeks at a time.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Clos Cream during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Clos Cream during breastfeeding is not available. Please consult your doctor.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Frequently asked questions

No, Clos Cream should not be used for a long time. The doctor generally prescribes it for 2 consecutive weeks only. However, the treatment can be longer for chronic (long-term) inflammatory conditions. Consult your physician before using this medication.
Severe skin reactions are quite rare with Clos Cream. Clos Cream is an anti-inflammatory drug which is used to treat skin diseases, skin reactions and eczemas. However, skin reactions can occur in a person who is hypersensitive to Clos Cream. It is important to leave the affected area open after applying Clos Cream as using occlusive dressings (air- and water-tight dressing) can lead to skin reactions. The medicine may not itself cause a reaction but the added excipients with the medications can lead to a reaction in some cases. Inform your doctor immediately in case you encounter any skin reactions.
No, Clos Cream should not be used on the face. In addition to this, Clos Cream should also not be used on the axillae (armpits), groin, and if there is atrophy (wasting away of tissues) at the treatment site. In certain circumstances, it can be exceptionally considered to be used by doctors. It should be used only after consultation with your physician and if possible, the application on the face should be limited to a maximum of 5 days.
Clos Cream is not recommended for use in children less than 1 year of age. It is also not recommended for use in older children and adolescents as the side effects are more common in them. In the pediatric population, there is an increased risk of suppression of the immune system which may make the child prone to other diseases and atrophic changes, hence it is not recommended. Still, in some rare cases, the doctor may recommend this medicine, but the treatment is usually limited to 5 days and the therapy is reviewed weekly.
Clos Cream is not an antimicrobial or antifungal agent. It is a steroid medication. It should not be used in infections as being a corticosteroid, it suppresses the immune system and increases the risk of infections. Bacterial infections are prone to worsen if the infection is covered with a dressing after using Clos Cream. In case the inflammatory lesions get infected or there is any spread of infection, consult your doctor immediately. The doctor will withdraw the use of Clos Cream and provide appropriate antimicrobial therapy.
No, do not stop taking Clos Cream and finish the full course of treatment even if you feel better. Your symptoms may improve before your treatment is complete. Stopping Clos Cream before your treatment is completed can bring back your symptoms.
Local skin reactions are quite rare with Clos Cream. Being an anti-inflammatory drug, it is used to treat skin diseases, skin reactions, and eczemas. Still, skin reactions can occur in a person who is hypersensitive to Clos Cream. It is important to leave the affected area open after applying Clos Cream as using occlusive dressings (air- and water-tight dressing) can lead to skin reactions. If not by the medicine itself, sometimes the reactions are also caused by the added excipients with the medications. Inform your doctor immediately in case you encounter any skin reactions.
No, Clos Cream should not be used for a long time. It is generally prescribed for 2 consecutive weeks only. However, the treatment can be longer for chronic (long-term) inflammatory conditions. Consult your physician before using this medication.
Severe skin reactions are quite rare with Clos Cream. Clos Cream is an anti-inflammatory drug which is used to treat skin diseases, skin reactions and eczemas. However, skin reactions can occur in a person who is hypersensitive to Clos Cream. It is important to leave the affected area open after applying Clos Cream as using occlusive dressings (air- and water-tight dressing) can lead to skin reactions. The medicine may not itself cause a reaction but the added excipients with the medications can lead to a reaction in some cases. Inform your doctor immediately in case you encounter any skin reactions.
No, Clos Cream should not be used on face. Along with that, its use should be avoided in other areas like the axillae (armpits), groin and if there is atrophy (wasting away of tissues) at the treatment site. However, in certain circumstances, the doctor may prescribe Clos Cream only when considered necessary. It should be used only after consultation with your physician. and if possible, the application on face should be limited to a maximum of 5 days.
Clos Cream is not recommended to be used in children less than 1 year of age. Other than that, its use should be avoided in older children and adolescents as the side effects are more common in them. This is because there is an increased risk of suppression of the immune system in young children which may make them prone to other diseases and atrophic changes. However, in some rare cases, the doctor may recommend this medicine, but the treatment is usually limited to 5 days and the therapy is reviewed weekly.
Clos Cream is not an antimicrobial or antifungal agent. It is a steroid medication which can suppress the immune system and increase the risk of infections. Hence, it should not be used for treating infections. In case the inflammatory lesions get infected or there is any spread of infection, consult your doctor immediately. The doctor will withdraw the use of Clos Cream and provide appropriate antimicrobial therapy.
No, do not stop taking Clos Cream and finish the full course of treatment even if you feel better. Your symptoms may improve before your treatment is complete. Stopping Clos Cream before your treatment is completed can bring back your symptoms.
Local skin reactions are quite rare with Clos Cream. Being an anti-inflammatory drug, it is used to treat skin diseases, skin reactions, and eczemas. Still, skin reactions can occur in a person who is hypersensitive to Clos Cream. It is important to leave the affected area open after applying Clos Cream as using occlusive dressings (air- and water-tight dressing) can lead to skin reactions. If not by the medicine itself, sometimes the reactions are also caused by the added excipients with the medications. Inform your doctor immediately in case you encounter any skin reactions.

Fact Box

Chemical Class

Gluco/mineralocorticoids, progestogin derivative

Habit Forming

No

Therapeutic Class

DERMA

Action Class

Glucocorticoids

References

  1. Clobetasol [EMC SmPC]. Uxbridge, Middlesex: GlaxoSmithKline UK; 2017. [Accessed 04 Apr. 2019] (online) Available from:
  2. Clobetasol [Prescribing Information]. Melville, New York: Fougera Pharmaceuticals Inc.; 2012. [Accessed 04 Apr. 2019] (online) Available from:
  3. Clobetasol propionate [Prescribing Information]. Fort Worth, Texas: GALDERMA LABORATORIES, L.P.; 2012. [Accessed 20 Feb. 2024] (online) Available from:
  4. Clobetasol propionate [Package Leaflet: Information for User]. Barnard Castle, UK: Glaxo Operations UK Limited; 2024.
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Syswin Pharmaceuticals Pvt Ltd
Address: NO.3919, 1ST CROSS, GIRINAGAR 4TH PHASE, BANGALORE Bangalore KA 560085 INDIA

Vendor Details

Country of origin: India

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