Cilastat Injection

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Primarily used for

Serious bacterial infections
1110
1 Injection in 1 vial
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Medicine Overview of Cilastat Injection

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Uses of Imipenem

Imipenem is used in serious bacterial infections
It is used in infections of various body parts like skin and soft tissues, urinary tract, blood, brain and lungs (pneumonia).
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Side effects of Imipenem

Common

Nausea, Vomiting, Seizure.

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How to use Imipenem

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Cilastat Injection works

Imipenem is an antibiotic. It kills bacteria by preventing them from forming their own protective covering which is required for their survival in the human body.
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Uses of Cilastatin

Cilastatin is used in the treatment of serious bacterial infections.
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Side effects of Cilastatin

Common

Vomiting, Nausea, Allergic reaction, Confusion, Diarrhoea, Fever, Rash.

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How to use Cilastatin

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Cilastat Injection works

Cilastatin blocks the enzymes that destroys other antibiotics.

In Depth Information on Cilastat Injection

Expert advice for Imipenem

  • Imipenem is given as a powder for solution for intravenous infusion by a doctor or nurse using a suitable infusion fluid.
  • Do not start or continue the imipenem, if you have kidney, liver, or urinary problems; history of fits (seizures) or central nervous system problems (e.g. tremors).
  • Do not take imipenem if you experience inflammation of the large intestine (colitis) or any other gastrointestinal disease.
  • Do not drive or operate heavy machinery because you may feel sleepy or dizzy while being treated with imipenem.
  • Avoid using imipenem, if you are pregnant, planning to become pregnant or breastfeeding.

Expert advice for Cilastatin

  • You will be monitored for kidney and liver function due to the risk of toxicity.
  • Tell your doctor if you are on a controlled sodium diet, as cilastatin contains sodium.
  • Tell your doctor if you are pregnant or are planning to be pregnant or are breastfeeding.
  • Tell your doctor if you have or have ever had seizures; a brain injury; kidney, liver, or gastrointestinal disease (especially colitis); or asthma.
  • Do not take if patient is allergic to cilastatin or any of its ingredients.
  • Do not take children less than 1 year, and child with a brain or nervous system infection, or weighs less than 66 lb (30 kg) and has kidney problems
 
Warnings
Special precautions for Cilastat Injection
Alcohol
Interaction with alcohol is unknown. Please consult your doctor.
Pregnancy
WEIGH RISKS VS BENEFITS
Cilastat Injection may be unsafe to use during pregnancy.

Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
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Lactation
Cilastat Injection is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
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Driving
Do not drive unless you are feeling well.

There are some side effects associated with Cilastat Injection (such as seeing, hearing something that does not exist and this may affect some patient's ability to drive)
There are some side effects associated with this medicine (such as seeing, hearing, or feeling something that is not there) that may affect some patients' ability to drive.
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Kidney
CAUTION
Cilastat Injection should be used with caution in patients with kidney disease. Dose adjustment of Cilastat Injection may be needed. Please consult your doctor.

Patients with advanced kidney disease are at high risk of seizures. Regular monitoring of kidney function test is advised while you are taking this medicine.
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Liver
There is limited information available on the use of Cilasta
t Injection in patients with liver disease. Please consult your doctor.
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Patient Concerns

Frequently asked questions for Cilastat Injection

Frequently asked questions for Imipenem

Q. Is imipenem a penicillin or beta lactam drug?
Imipenem is not a penicillin drug. It is a carbapenem beta-lactam antibiotic
Q. Is Imipenem nephrotoxic or cause seizures?
Ganciclovir along with Imipenem can increase risk of seizures. Imipenem generally not been shown to cause nephrotoxicity. Please consult your doctor if you experience these side effects
Q. What is imipenem-cilastatin used for?
Imipenem and cilastatin are used as combination therapy for bacterial infections. Cilastatin reduces the inactivation of imipenem from enzymes released from kidney and extends their spectrum of activity
Q. What organisms does Imipenem cover?
Imipenem is active against most of the gram-positive and gram-negative bacteria, aerobes as well as anaerobes. It is effective against pseudomonas, legionella, and acinetobacter, and many other; not treatable by other antibiotics.
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Substitutes for Cilastat

No substitutes found for this medicine
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