Biproate 500 Tablet CR is a combination of two medicines used to treat epilepsy, a neurological disorder in which there are recurrent episodes of seizures or fits. It controls the abnormal activity of the brain, relaxes the nerves and hence, prevents seizures or fits.
Biproate 500 Tablet CR should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse.
The most common side effects of this medicine include nausea, vomiting, loss of appetite, swelling of gums, headache, sleepiness, tremor, hair loss and liver injury. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects.
Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Biproate 500 Tablet CR can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine.
You should avoid alcohol while taking Biproate 500 Tablet CR, as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior.
Biproate 500 Tablet CR slows down electrical signals in the brain which cause seizures (fits). It can also help reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety. The medicine can allow you to do some activities that you would otherwise be forbidden or scared to do (such as swimming and driving). It can take a few weeks for this medicine to work (because the dose has to be increased slowly) and during this time you may still have seizures. Do not stop using this medicine even if you feel well, until your doctor advises you to. Missing doses may trigger a seizure.
Side effects of Biproate Tablet CR
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Biproate
Loss of appetite
Increased liver enzymes
Decreased sodium level in blood
Anemia (low number of red blood cells)
Pain during periods
How to use Biproate Tablet CR
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Biproate 500 Tablet CR is to be taken with food.
How Biproate Tablet CR works
Biproate 500 Tablet CR is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.
It is unsafe to consume alcohol with Biproate 500 Tablet CR.
CONSULT YOUR DOCTOR
Biproate 500 Tablet CR is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
SAFE IF PRESCRIBED
Biproate 500 Tablet CR is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Biproate 500 Tablet CR may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
SAFE IF PRESCRIBED
Biproate 500 Tablet CR is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Biproate 500 Tablet CR may not be needed in these patients. Please consult your doctor. However, talk to your doctor if you have any underlying kidney disease.
Biproate 500 Tablet CR should be used with caution in patients with liver disease. Dose adjustment of Biproate 500 Tablet CR may be needed. Please consult your doctor. Use of Biproate 500 Tablet CR is not recommended in patients with severe liver disease and active liver disease.
What if you forget to take Biproate Tablet CR?
If you miss a dose of Biproate 500 Tablet CR, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
For informational purposes only. Consult a doctor before taking any medicines.
You have been prescribed Biproate 500 Tablet CR for treatment and prevention of seizures.
Take it at the same time every day to maintain consistent levels in your body.
Do not drive or do anything that requires mental focus until you know how Biproate 500 Tablet CR affects you.
Avoid consuming alcohol when taking Biproate 500 Tablet CR, as it may cause excessive sleepiness or drowsiness.
Monitor your weight during the treatment as Biproate 500 Tablet CR can cause weight gain.
Your doctor may monitor Biproate 500 Tablet CR level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin.
Do not take Biproate 500 Tablet CR if you are pregnant or planning to conceive or breastfeeding.
Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
3-4 attack of strokes in 3 yrs nothing found in CT scan & EEG.these tests are done again after 3 months. But nothing found. Doctors prescribed me Oxetol 450 mg.doctor say course of medicine is 2-3 yrs.I drink and smoke addicted to drug I don't understand if the test show nothing then why strokes happens to me?
Dr. Vikas Sharma
is it stroke or epilepsy; as u are on medicine for epilepsy
My mother has got faint today. After that we have taken her to emergency Dr. has checked and opt for CT scan head. And report is normal. Only focal calcification seen in left frontal lobe. Please tell me?this is ok or any thing to worry.
My child have sudden upnormal contion above 8 years.we checked local doctors and they said its a silent fits its not cure .where we go this speclasit doctor around tamilnadu.we are poor family so kind u correct treatment
Q. Can the use of Biproate 500 Tablet CR cause sleepiness or drowsiness?
Yes, Biproate 500 Tablet CR may make you feel drowsy or sleepy. Avoid driving, operating machinery, working at heights or participating in potentially dangerous activities. Inform your doctor if you experience such an episode while taking this medicine.
Q. Can I drink alcohol while taking Biproate 500 Tablet CR?
No, avoid drinking alcohol while taking Biproate 500 Tablet CR. Drinking alcohol will increase the side effects caused by Biproate 500 Tablet CR.
Q. Can Biproate 500 Tablet CR be stopped when epilepsy symptoms are relieved?
No, Biproate 500 Tablet CR should be continued as advised by the doctor. Stopping Biproate 500 Tablet CR suddenly may cause the symptoms to reappear that too with increased frequency. If any problems are experienced due to Biproate 500 Tablet CR, consult the doctor for re-evaluation.
Q. Will a higher than the recommended dose of Biproate 500 Tablet CR be more effective?
No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having serious side effects and toxicity. If the recommended doses do not relieve your symptoms or there is an increased severity of your symptoms, please consult your doctor.
Q. What are the instructions for the storage and disposal of Biproate 500 Tablet CR?
Keep this medicine in the container it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
Linde M, Mulleners WM, Chronicle EP, et al. Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database Syst Rev. 2013;(6):CD010611. [Accessed 23 Apr. 2019] (online) Available from:
Drugs.com. Sodium Valporate. [Accessed 23 Apr. 2019] (online) Available from:
Drugs.com. Valporic acid. [Accessed 23 Apr. 2019] (online) Available from:
Sodium Valproate and Valproic Acid [Package Information]. Gangtok, Sikkim: TORRENT PHARMACEUTICALS LTD.; 2022. [Accessed 28th Sept. 2023] (online) Available from:
Name: Consern Pharma Limited
Address: Consern Pharma Private Limited, Kuljive Mahajan(Mg. Director), Rural Focal Point, V.P.O. Tibba, Ludhiana - 141120, Punjab, India
Country of origin: India
The list of available options shown with the same composition has been prepared upon the advice of registered medical practitioners, pharmacists affiliated with TATA 1MG. TATA 1MG does not promote any pharmaceutical product of any particular company, and all recommendations are based on the medical opinion, advisories from specialist medical and pharmaceutical professionals.