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MD (Pharmacology), MBBS
Last updated on:
05 Nov 2019 | 10:19 AM (IST)
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Overview

Introduction

Axinerve-NP Tablet is a combination medicine used to treat neuropathic pain. This medicine decreases pain by controlling calcium channel activity of the nerve cells. It also increases the level of chemical messengers in the brain that help in regulating the mood and protect nerve fibers.

Axinerve-NP Tablet can be taken with or without food. However, it is advisable to take it at the same time each day as this helps to maintain consistent level of medicine in the body. Take this medicine in the dose and duration advised by doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly as it may worsen your symptoms.

Some common side effects of this medicine include peripheral edema, dryness in mouth, increased heart rate, constipation, difficulty in concentration and blurred vision. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should have a balanced diet and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Uses of Axinerve-NP Tablet

Axinerve-NP Tablet side effects

Common
  • Constipation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Increased heart rate
  • Dizziness
  • Sleepiness
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Uncoordinated body movements

How to use Axinerve-NP Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Axinerve-NP Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Axinerve-NP Tablet works

Axinerve-NP Tablet is a combination of three medicines: Pregabalin, Nortriptyline and Methylcobalamin/Mecobalamin. Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin/Mecobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

Axinerve-NP Tablet related warnings

Alcohol
UNSAFE
Axinerve-NP Tablet may cause excessive drowsiness with alcohol
Pregnancy
CONSULT YOUR DOCTOR
Axinerve-NP Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Lactation
CONSULT YOUR DOCTOR
Axinerve-NP Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Axinerve-NP Tablet may cause side effects which could affect your ability to drive.
As Axinerve-NP Tablet may affect your alertness which may affect your ability to drive.
Kidney
CAUTION
Axinerve-NP Tablet should be used with caution in patients with kidney disease. Dose adjustment of Axinerve-NP Tablet may be needed. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Axinerve-NP Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Axinerve-NP Tablet may not be needed in these patients. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Axinerve-NP Tablet
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Nervite Plus Tablet
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Adnurve SR Tablet
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Patient Concerns

Questions Related to Axinerve-NP

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NP, DIABETIC RETINOPATHY, MACULAR EDEMA
Dr. Richa Jain
Eye Specialist
U might need laser. . Visit retina specialist
Most of the times when I get excited or have orgasm I feel pain in my testis and around it .
Dr. Pranay Gandhi
Sexologist
hi PATIENT neuropathic pain mostly. take tablet emanzen d 1 bd
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FAQs

Q. What is Axinerve-NP?

Axinerve-NP is a combination of three medicines: Gabapentin, Nortriptyline and Methylcobalamin. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

Q. Can I stop taking Axinerve-NP when my pain is relieved?

No, you should not stop taking Axinerve-NP even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Axinerve-NP, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.

Q. How to manage weight gain associated with the use of Axinerve-NP?

Axinerve-NP can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.

Q. Can the use of Axinerve-NP cause sleepiness or drowsiness?

Yes, Axinerve-NP may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights, or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.

Q. Can the use of Axinerve-NP affect my sexual life?

The use of Axinerve-NP can affect the sexual life of both men and women. Most commonly observed problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while intercourse. If you experience these problems, discuss them with your doctor but do not stop taking Axinerve-NP.

Q. Are there any serious side effects associated with the use of Axinerve-NP?

Serious side effects because of Axinerve-NP are uncommon and rare. Consult your doctor if you notice any of the following: changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior (such as restlessness, nervousness or excitement), signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and need urgent medical attention.

Q. How long will Axinerve-NP take to act?

An initial benefit with Axinerve-NP may be seen after 2 weeks of the treatment. However, it may take around 2-3 months or more to see full benefits and even.

Q. What if I forget to take Axinerve-NP?

If you forget to take the scheduled dose of Axinerve-NP and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect. If you are not sure what to do, consult your about how to manage a situation like this.

Q. What if I take too much of this drug by mistake?

In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteadiness while walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heartbeat.

Q. Will a higher than the recommended dose of Axinerve-NP be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

Q. Is there anything I need to avoid while taking Axinerve-NP?

Axinerve-NP may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while you are taking Axinerve-NP. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Axinerve-NP can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.

Q. How often should I see the doctor?

You may need to see your doctor regularly if you have started to take Axinerve-NP. However, you must consult your doctor if the advised dosage of Axinerve-NP does not improve your symptoms or you continue experiencing some unwanted side effects that affect your routine activities.

Q. Are there any special instructions regarding storage and disposal of this medicine?

Keep your tablets in the pack until it is time to take them. Store them in a cool dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

Q. Does Axinerve-NP expire?

Yes, Axinerve-NP does expire. Please check the expiry date written on the pack of this medicine. Do not use Axinerve-NP after the expiry date.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Pregabalin. Sandwich, Kent: Pfizer Limited; 2009 [revised July 2018]. [Accessed 24 Apr. 2019] (online) Available from:External Link
  2. Drugs.com. Nortriptyline Pregnancy and Breastfeeding Warnings. [Accessed 24 Apr. 2019] (online) Available from:External Link
  3. Drugs.com. Cyanocobalamin Pregnancy and Breastfeeding Warnings. [Accessed 24 Apr. 2019] (online) Available from:External Link
Manufacturer/Marketer Address
550 Tower - A, Spaze I Tech Park Sohna Road, Sector 49, Gurgaon - 122002
A licensed pharmacy from your nearest location will deliver Axinerve-NP Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your prescription and the availability of this medicine.
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