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26 Dec 2019 | 03:41 PM (IST)
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Overview

Introduction

Nervite Plus Tablet is a combination medicine used to treat neuropathic pain. It works by decreasing pain by controlling calcium channel activity of the nerve cells. It also increases the level of chemical messengers in the brain that help in regulating the mood and protect nerve fibers.

Nervite Plus Tablet can be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration advised by the doctor. If you miss a dose of this medicine, take it as soon as you remember. Finish the full course of the treatment even if you feel better. It is important not to stop taking this medicine suddenly as it may worsen your symptoms.

Some common side effects of this medicine include constipation, weight gain, increased heart rate,  and dryness in mouth. It may cause dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This medicine may cause weight gain and to control it, you should have a balanced diet and exercise regularly. You must inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts.

Before taking this medicine let your doctor know if you suffer from kidney or liver disease. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Uses of Nervite Plus Tablet

Side effects of Nervite Plus Tablet

Common
  • Constipation
  • Weight gain
  • Orthostatic hypotension (sudden lowering of blood pressure on standing)
  • Increased heart rate
  • Dizziness
  • Sleepiness
  • Tiredness
  • Blurred vision
  • Dryness in mouth
  • Difficulty in urination
  • Uncoordinated body movements

How to cope with side effects?

The occurrence of side effects varies from person to person. The following are a few ways of dealing with some of the common side effects. However, consult your doctor if these persist.

  • Coping with Constipation
    Try to eat foods which are high in fiber such as fresh fruits, vegetables and cereals to increase the bulk and consistency of bowel movements. Drink plenty of water or non-alcoholic drinks and stay hydrated to promote healthy digestion. Increasing physical activities such as walking, yoga and regular exercise can also be helpful. If your condition does not improve, you can ask your doctor to prescribe you laxative medicine.
  • Coping with Weight gain
    Try to eat a healthy balanced diet without increasing your portion sizes. Avoid processed meat or poultry and seafood. Eat small, frequent meals and eat slowly. Do not snack on foods that contain a lot of calories such as crisps, cakes, biscuits and sweets. If you feel hungry between meals, eat fruits and vegetables which have low calories. Avoid reaching for a sugary drink if you feel stressed. Fasting once a week can be an effective way to lose weight. Make sure you get enough sleep. With proper diet and lifestyle changes, you might not gain any weight or may gain only a small amount. Even then if it bothers you, ask your doctor if there are any alternative medicines that do not have this side effect.
  • Coping with Increased heart rate
    Breathe in slowly through your nostrils and then breathe out through your mouth. Repeat this until you feel calm. Try sitting cross-legged and drink plenty of water. Splash cold water or apply a cold towel or ice pack on your face for 20-30 seconds. It is important to make sure that you are not taking more than the prescribed dose. As a preventive measure, you should limit the amount of alcohol you drink and give up smoking. Also, cut down the amount of coffee, tea or cola you drink. In general, being physically active and eating a healthy well-balanced diet is good advice for any heart condition. If the condition does not improve, consult your doctor as they may need to change you to a different type of medicine.
  • Coping with Dizziness
    This is usually short-lived and should go away within a few days. If this happens, stop what you are doing and sit or lie down until you feel better. Lying still in a dark, quiet room may help reduce the spinning feeling. Sleep with your head slightly raised on two or more pillows. Get up slowly from a lying or sitting position. Get plenty of rest and try to relax as being anxious can make it worse. Try taking this medicine at bedtime to reduce the symptoms. Drinking plenty of water and ginger tea may also help. Avoid alcohol, caffeine and smoking as it will make you feel worse. Avoid driving or using tools or machinery until you feel better.
  • Coping with Sleepiness
    If the medicine is making you drowsy during the day, stop what you are doing and sit or lie down until you feel better. You can also consider taking a nap. Physical exercises such as walking may be helpful. Do not drink alcohol, as it will make you feel more tired. Avoid driving or operating heavy equipment when you are feeling drowsy. This problem usually goes away as your body gets used to the medicine. However, if it does not, ask your doctor if you can take your medicine at bedtime or whether the dose can be reduced.
  • Coping with Tiredness
    Make sure you rest and drink plenty of fluids. Eat a well-balanced diet to keep your energy levels up. Do not drink too much alcohol. Do not drive or use tools or machinery until you feel better. Other things that can help include doing some gentle exercise every day, prioritizing and pacing your activities and having a short nap if you need to. If you are still having problems after a week, speak to your doctor, as they may want to change you to a different type of medicine.
  • Coping with Blurred vision
    You can consider washing your eyes with water. Avoid driving or using tools or machines if your vision is impaired. Do not take your next dose if your vision is still blurry. If it gets worse or does not improve, ask your doctor to recommend eye drops or talk about changing your medications.
  • Coping with Dryness in mouth
    Keep a drink available that you can sip through the day. Rinse your mouth with warm salted water and chew sugarless gum or hard candy. Try breathing through your nose more often than your mouth. Avoid caffeinated beverages, smoking and alcohol because they can make your condition worse. Use lip balm if your lips are also dry. Try to avoid foods that are acidic (like lemons), spicy, salty or sugary. If this side effect bothers you or does not go away, talk to your doctor about artificial saliva products or other suitable treatments.
  • Coping with Difficulty in urination
    Relax when you try to pee. Don't try to force the flow of urine. If it doesn't happen, try again later. Limit drinks that increase urination such as coffee, tea and other caffeinated beverages. Continue to drink plenty of water each day. Gentle massage and hot compression on your lower abdomen can help relax your muscles and may improve your urine flow. Doing exercises that strengthen the bladder muscles such as pelvic exercise will be of help. Distract your attention by thinking about something else. Avoid alcohol and smoking because both can aggravate the condition. Talk to your doctor urgently if you can not pee at all.

How to use Nervite Plus Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Nervite Plus Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Nervite Plus Tablet works

Nervite Plus Tablet is a combination of three medicines: Pregabalin, Nortriptyline and Methylcobalamin/Mecobalamin. Pregabalin is an alpha 2 delta ligand which decreases pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Methylcobalamin/Mecobalamin is a form of vitamin B which helps in the production of myelin, a substance that protects nerve fibers and rejuvenates damaged nerve cells. Together, they relieve neuropathic pain (pain from damaged nerves).

Safety Advice

Alcohol
UNSAFE
Nervite Plus Tablet may cause excessive drowsiness with alcohol.
Pregnancy
CONSULT YOUR DOCTOR
Nervite Plus Tablet may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Nervite Plus Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Nervite Plus Tablet may cause side effects which could affect your ability to drive.
As Nervite Plus Tablet may affect your alertness which may affect your ability to drive.
Kidney
CAUTION
Nervite Plus Tablet should be used with caution in patients with kidney disease. Dose adjustment of Nervite Plus Tablet may be needed. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Nervite Plus Tablet is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Nervite Plus Tablet may not be needed in these patients. Please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
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Patient Concerns

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Most of the times when I get excited or have orgasm I feel pain in my testis and around it .
Dr. Pranay Gandhi
Sexology
hi PATIENT neuropathic pain mostly. take tablet emanzen d 1 bd
for body pain relief i taking dolokind - plus tablet I asking advise sir which is best for long time
Dr. Pushkar Mani
Physician
for long time no pain killer is goodfirst need to diagnose the reason of pain
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User Feedback


FAQs

Q. What is Nervite Plus?

Nervite Plus is a combination of three medicines: Gabapentin, Nortriptyline and Methylcobalamin. This medicine is useful in the treatment of nerve pain (neuropathic pain). This medicine calms the damaged or overactive nerves by acting on brain, thereby decreasing the pain sensation. It also helps in the regeneration of damaged nerves in the body.

Q. Can I stop taking Nervite Plus when my pain is relieved?

No, you should not stop taking Nervite Plus even if your pain is relieved. Continue to take it as advised by your doctor. If you suddenly stop taking Nervite Plus, you may experience withdrawal symptoms such as anxiety, sleeping difficulties, nausea, pain and sweating. You may need to gradually taper the dose before you stop the medication completely.

Q. How to manage weight gain associated with the use of Nervite Plus?

Nervite Plus can make you feel hungry which might make you eat more, thereby increasing your chances of putting on weight. However, preventing weight gain is easier than losing the increased weight. Try to eat a healthy balanced diet without increasing your portion sizes (per-meal intake). Do not eat food items that contain a lot of calories, such as soft drinks, oily food, chips, cakes, biscuits and sweets. If you feel hungry between meals, avoid eating junk food and eat fruits, vegetables and low-calorie foods. Regular exercise will help prevent weight gain. If you maintain good eating habits and exercise regularly, you might not gain any weight.

Q. Can the use of Nervite Plus cause sleepiness or drowsiness?

Yes, Nervite Plus may make you feel drowsy or you may suddenly fall asleep during your daily activities. Sometimes, you might not even feel drowsy or have any other warning signs before you suddenly fall asleep. Avoid driving a car, operating machinery, working at heights, or participating in potentially dangerous activities at the beginning of your treatment until you know how the medicine affects you. Inform your doctor if you experience such episodes while you are taking this medicine.

Q. Can the use of Nervite Plus affect my sexual life?

The use of Nervite Plus can affect the sexual life of both men and women. Most commonly observed problems are decreased sexual desire, erectile dysfunction (inability to develop or maintain erection during the sexual activity) and inability to reach orgasm. It can also cause a decrease in satisfaction and cause discomfort while intercourse. If you experience these problems, discuss them with your doctor but do not stop taking Nervite Plus.

Q. Are there any serious side effects associated with the use of Nervite Plus?

Serious side effects because of Nervite Plus are uncommon and rare. Consult your doctor if you notice any of the following: changes in body temperature, difficulty in breathing, increased heartbeat (palpitations), weakness, unsteadiness when walking, reduced coordination or slowed reactions, unusual changes in mood or behavior (such as restlessness, nervousness or excitement), signs of depression, seeing or hearing things that are not there, irrational thinking, blurred or double vision, uncontrollable jerky eye movements, difficulty seeing, signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers. These side effects are uncommon but may be serious and need urgent medical attention.

Q. How long will Nervite Plus take to act?

An initial benefit with Nervite Plus may be seen after 2 weeks of the treatment. However, it may take around 2-3 months or more to see full benefits and even.

Q. What if I forget to take Nervite Plus?

If you forget to take the scheduled dose of Nervite Plus and it is almost time for your next dose, skip the dose you missed and take your next dose at the scheduled time. Otherwise, take it as soon as you remember, and then go back to taking your medicine as you would normally. Do not take a double dose to make up for the dose you missed because this may increase the risk of unwanted side effect. If you are not sure what to do, consult your about how to manage a situation like this.

Q. What if I take too much of this drug by mistake?

In a situation like this, contact your doctor immediately or seek emergency help at the nearest hospital. Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention. Symptoms of an overdose may include drowsiness, weakness, unsteadiness while walking, having double visions, slurred speech or diarrhea, confusion, blurred vision, dizziness, body temperature changes (low and high), difficulty in breathing and increased heartbeat.

Q. Will a higher than the recommended dose of Nervite Plus be more effective?

No, taking a higher than the recommended dose may not be more effective, rather it may increase the chances of having some serious side effects and toxicity. If you experience increased severity of your symptoms, that are not relieved by the recommended doses, please consult your doctor for re-evaluation.

Q. Is there anything I need to avoid while taking Nervite Plus?

Nervite Plus may impair your thinking or reactions. Be careful while driving or doing an activity that requires you to be alert. Do not drink alcohol while you are taking Nervite Plus. It can increase the effects of alcohol, which could be dangerous. Grapefruit and grapefruit juice may also interact with this medicine and cause unwanted side effects. Avoid exposure to sunlight or tanning beds. Use of Nervite Plus can make you more prone to sunburns. Wear protective clothing and use sunscreen when you are outdoors during daytime.

Q. How often should I see the doctor?

You may need to see your doctor regularly if you have started to take Nervite Plus. However, you must consult your doctor if the advised dosage of Nervite Plus does not improve your symptoms or you continue experiencing some unwanted side effects that affect your routine activities.

Q. Are there any special instructions regarding storage and disposal of this medicine?

Keep your tablets in the pack until it is time to take them. Store them in a cool dry place. Store them out of sight and reach of children. Unused medications should be disposed of in special ways to ensure that pets, children and other people cannot consume them.

Q. Does Nervite Plus expire?

Yes, Nervite Plus does expire. Please check the expiry date written on the pack of this medicine. Do not use Nervite Plus after the expiry date.

Related Products

Disclaimer: 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
References
  1. Pregabalin. Sandwich, Kent: Pfizer Limited; 2009 [revised July 2018]. [Accessed 24 Apr. 2019] (online) Available from:External Link
  2. Drugs.com. Nortriptyline Pregnancy and Breastfeeding Warnings. [Accessed 24 Apr. 2019] (online) Available from:External Link
  3. Drugs.com. Cyanocobalamin Pregnancy and Breastfeeding Warnings. [Accessed 24 Apr. 2019] (online) Available from:External Link
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