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21 Feb 2020 | 12:19 PM (IST)
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Avastin 400mg Injection

Prescription Required
SALT COMPOSITION
Storage
Store in a refrigerator (2 - 8°C). Do not freeze.

Introduction

Avastin 400mg Injection is an anticancer medication. It is used in the treatment of cancer of colon and rectum, non-small cell lung cancer, kidney cancer, brain tumor, ovarian and cervical cancer. It helps to prevent the growth of new blood vessels that feed tumors and stops tumors from growing.

Avastin 400mg Injection is an effective medicine, first-line option when used together with other cancer medicines. It is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. The doctor will decide your dose and duration and will check you for signs of an infusion reaction such as high blood pressure and trouble breathing. You keep taking Avastin 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking it or not. You may be advised to check blood pressure and levels of protein in urine while you are taking this medication.

The most common side effects of this medicine include rectal bleeding, taste change, and headache. Inform your doctor that you are taking this medication before undergoing any surgical procedure, as the drug has ability to lower the ability of wound healing. Other than this, it also enhances your risk of bleeding thus if you notice any unusual bleeding or bleeding consult with your doctor immediately.

Inform your doctor if you are pregnant, planning pregnancy or breastfeeding. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using.

Side effects of Avastin Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Avastin

  • Rectal bleeding
  • Taste change
  • Headache
  • Nosebleeds
  • Back pain
  • Dry skin
  • High blood pressure
  • Protein in urine
  • Inflammation of the nose

How to use Avastin Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Avastin Injection works

Avastin 400mg Injection is a anti-angiogenic medication. It works by blocking a protein called vascular endothelial growth factor (VEGF). This stops the formation of blood vessels that bring oxygen and nutrients to cancerous cells.

Safety Advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Avastin 400mg Injection. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Avastin 400mg Injection may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Breastfeeding
CONSULT YOUR DOCTOR
Avastin 400mg Injection is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Driving
UNSAFE
Avastin 400mg Injection may cause side effects which could affect your ability to drive.
Sleepiness and fainting have been reported with Avastin 400mg Injection and this may impair your ability to drive.
Kidney
SAFE IF PRESCRIBED
Avastin 400mg Injection is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Avastin 400mg Injection may not be needed in these patients. Please consult your doctor.
Liver
SAFE IF PRESCRIBED
Avastin 400mg Injection is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Avastin 400mg Injection may not be needed in these patients. Please consult your doctor.

What if you forget to take Avastin Injection?

If you miss a dose of Avastin 400mg Injection, please consult your doctor.

Alternate Brands

For informational purposes only. Consult a doctor before taking any medicines.
Avastin 400mg Injection
₹7250.0/ml of Injection
Bevacirel 400mg Injection
Reliance Life Sciences
₹2428.52/ml of Injection
save 66%
₹2710.59/ml of Injection
save 63%
Abevmy 400mg Injection
Mylan Pharmaceuticals Pvt Ltd
₹35120/Injection
384% costlier
₹35777.44/Injection
393% costlier
₹99360/Injection
1270% costlier

Quick Tips

  • Avastin 400mg Injection is an effective, first-line option when used together with other medicines for certain types of cancers such as colorectal, lung, cervical, and kidney cancers.
  • Avastin 400mg Injection is given as an infusion. Your doctor or nurse will monitor you for signs of an infusion reaction such as high blood pressure and trouble breathing.
  • It can lower your wound healing ability. Inform your doctor that you are taking this medication before undergoing any surgical procedure.
  • It can increase the risk of bleeding. Inform your doctor if you notice any unusual bleeding or bleeding that doesn't stop easily.
  • Your doctor may regularly check your blood pressure and levels of protein in your urine while you are on Avastin 400mg Injection.

Fact Box

Chemical Class
Monoclonal antibody (mAb)
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS

Patient Concerns

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What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma
Dr. Vijay Sharnangat
Medical Oncology and Hematology
This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer.
I want to know the symptoms of cancer as I am a smoker
Dr. Vijay Sharnangat
Medical Oncology and Hematology
Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.
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FAQs

Q. What kinds of cancer can Avastin 400mg Injection be used for ?

Avastin 400mg Injection is approved for the treatment of cancer of the colon or rectum that has spread to other parts of the body. It must be given along with chemotherapy. Other types of cancers that it helps with includes certain types of lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (a type of brain tumor).

Q. How is Avastin 400mg Injection given?

Avastin 400mg Injection is given as an infusion. That means you get it through a small needle in your vein or through a port, which is a device placed under your skin. Your doctor will decide your dose and duration and will monitor you for signs of an infusion reaction.

Q. How long can I take Avastin 400mg Injection for?

You keep taking Avastin 400mg Injection as long as your disease is controlled and your side effects are manageable. Your doctor will determine whether you should stop taking Avastin 400mg Injection. If your cancer progresses during this initial treatment, talk to your doctor if a different chemotherapy may be an option.

Q. How Avastin 400mg Injection works differently from chemotherapy?

Chemotherapy attacks fast-growing cells, like cancer cells. In contrast, the purpose of Avastin 400mg Injection is to prevent the growth of new blood vessels that feed tumors. This causes the tumour to shrink, or to stop growing.

Q. Does a person taking Avastin 400mg Injection still need chemotherapy?

Chemotherapy is still needed along with taking Avastin 400mg Injection. It makes chemotherapy work better.

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1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions or warnings or alerts. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1739-40.
  2. Chu E, Sartorelli AC. Cancer Chemotherapy. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. p. 955.
  3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 142-43.
  4. Bevacizumab. South San Francisco, California: Genentech, Inc.; 2004 [revised Sep. 2011]. [Accessed 26 Mar. 2019] (online) Available from:External Link
  5. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006. Bevacizumab. [Updated 2019 Jul 20]. [Accessed 18 Feb. 2020] (online) Available from:External Link
  6. Central Drugs Standard Control Organisation (CDSCO). [Accessed 27 Mar. 2019] (online) Available from:External Link

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1503, 15th Floor, ‘The Capital’, Plot no. C-70, Behind ICICI Bank, BKC, Bandra (E) , Mumbai 400051
Expires on or after: January, 2021

A licensed vendor partner from your nearest location will deliver Avastin 400mg Injection. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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16 ml in 1 vial
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