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Arzerra Injection

Written By Dr. Subita Alagh, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 31 Mar 2026 | 02:31 PM (IST)
Arzerra Injection is a prescription medicine used to treat relapsing forms of multiple sclerosis (MS). It works by targeting and depleting B cells, a type of white blood cell involved in the immune system’s attack on the nervous system in MS. It helps slow disease progression and reduce the number of relapses.
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Arzerra Injection image
Arzerra Injection image

Product introduction

Arzerra Injection is administered subcutaneously (under the skin). Administer the medicine as prescribed and do not skip any doses, as consistency helps maintain its effectiveness. To get the most benefit, follow up with your doctor regularly, stay up to date with vaccinations before starting treatment, and monitor for any signs of infection.


Common side effects of Arzerra Injection include injection-site reactions such as redness, swelling, or pain, as well as flu-like symptoms like fever, headache, chills, and fatigue, especially after the first doses. These symptoms usually improve with time. Some people may experience upper respiratory infections or urinary tract infections. Staying hydrated and practicing good hygiene can help reduce the risk. If side effects become severe or do not go away, consult your doctor for guidance.


Since Arzerra Injection lowers certain immune cells, it can increase the risk of infections, including serious ones like hepatitis B reactivation or upper respiratory infections. Before starting treatment, your doctor may check for infections and ensure your vaccinations are up-to-date. Avoid live vaccines while on treatment with Arzerra Injection, as they may not be safe. If you develop signs of infection, such as a persistent fever, sore throat, or unusual tiredness, seek medical advice promptly. People with a weakened immune system or a history of hepatitis B should discuss risks with their doctor before starting Arzerra Injection.


Pregnant or breastfeeding women should consult their doctor before using Arzerra Injection, as it may harm the baby. Both men and women should use effective contraception during treatment to prevent pregnancy. Arzerra Injection is a strong medication, so always follow your doctor's advice and report any concerns promptly to ensure the best results while minimizing risks.

Uses of Arzerra Injection

  • Treatment of Relapsing forms of multiple sclerosis (MS)

Benefits of Arzerra Injection

Treatment of Relapsing forms of multiple sclerosis (MS)
In individuals with relapsing forms of multiple sclerosis (MS), Arzerra Injection helps prevent relapses and slows the disability progression. It also helps reduce inflammation, decrease the frequency of flare-ups, minimize nerve damage, and improve long-term outcomes. When used as prescribed, Arzerra Injection helps patients maintain their independence, stay active, and improve their overall quality of life.

Side effects of Arzerra Injection

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Arzerra
  • Headache
  • Fever
  • Muscle pain
  • Chills
  • Tiredness
  • Injection site reactions (pain, swelling, redness)
  • Upper respiratory tract infection
  • Urinary tract infection

How to use Arzerra Injection

Your doctor or nurse will give you this medicine. Kindly do not self administer.

How Arzerra Injection works

Arzerra Injection is a medicine that targets and removes B cells, a type of immune cell that plays a role in multiple sclerosis (MS). It binds to a protein called CD20 on B cells, marking them for destruction. This helps reduce inflammation, lower the number of relapses, and slow down the damage to the nervous system. The treatment keeps B cells under control while allowing some to recover over time.

Quick tips

  • Administer Arzerra Injection as prescribed to maintain effectiveness. Set reminders if needed.
  • Report any signs of infection, such as fever, cough, or sore throat, to your doctor.
  • Get necessary vaccines at least 4 weeks before starting treatment, and avoid live vaccines during treatment.
  • Use birth control during treatment and for at least 6 months after stopping.
  • Drink plenty of water and rest to ease flu-like side effects.
  • Follow up regularly with your doctor to monitor progress and manage side effects early.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Arzerra Injection. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Arzerra Injection during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Arzerra Injection may be unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby. It should be used only if the expected benefit outweighs the potential risk. Please consult your doctor.
Driving

Driving

SAFE
Arzerra Injection does not usually affect your ability to drive.
Kidney

Kidney

SAFE IF PRESCRIBED
Arzerra Injection is safe to use in patients with kidney disease. No dose adjustment is recommended.
Liver

Liver

CONSULT YOUR DOCTOR
There is limited data available on the use of Arzerra Injection in patients with liver disease.

Interaction with drugs

Taking Arzerra with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Life-threatening

Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted) (Injection Route)

Do not use Ofatumumab with Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). If Ofatumumab is essential, ensure a gap of at least 12 months after discontinuing Herpes Zoster / Shingles Vaccine (Recombinant, Adjuvanted). Please consult your doctor.
Severe

Cholera Vaccine (Inactivated) (Oral Route)

Do not use Ofatumumab with Cholera Vaccine (Inactivated). If Ofatumumab is essential, ensure a gap of at least 12 months after discontinuing Cholera Vaccine (Inactivated). Please consult your doctor.
Severe

Purified Vi Polysaccharide Typhoid Vaccine (Injection Route)

Do not use Ofatumumab with Purified Vi Polysaccharide Typhoid Vaccine. If Ofatumumab is essential, ensure a gap of at least 12 months after discontinuing Purified Vi Polysaccharide Typhoid Vaccine. Please consult your doctor.

Fact Box

Chemical Class

Peptides

Habit Forming

No

Therapeutic Class

ANTI NEOPLASTICS

Action Class

Anti-CD20 Monoclonal Antibodies

References

  1. Chabner BA, Barnes J, Neal J, et al. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 1747-48.
  2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. p. 1011.
  3. Ofatumumab [Prescribing Information]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2024. [Accessed 03 Apr. 2025] (online) Available from:
  4. Ofatumumab [Summary of Product Characteristics]. Dublin 4, Ireland: Novartis Europharm Limited; 2021. [Accessed 03 Apr. 2025] (online) Available from:
  5. Ofatumumab [Professional Information]. Johannesburg, South Africa: Novartis South Africa (Pty) Ltd.; 2023. [Accessed 03 Apr. 2025] (online) Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Glaxo SmithKline Pharmaceuticals Ltd
Address: Dr. Annie Besant Road, Mumbai - 400 030

Vendor Details

Country of origin: India
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