Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Akurit Z Tablet is to be taken empty stomach. Avoid Akurit Z Tablet with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Akurit Z Tablet is a combination of three medicines: Isoniazid, Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide, on the other hand works by slowing the growth of these bacteria.
Akurit Z Tablet may cause symptoms such as flushing, increased heartbeat, nausea, thirst, chest pain and low blood pressure with alcohol (Disulfiram reactions).
WEIGH RISKS VS BENEFITS
Akurit Z Tablet may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the foetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Akurit Z Tablet is probably safe to use during lactation.
Limited human data suggests that the drug does not represent a significant risk to the baby.
Do not drive unless you are feeling well. You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.
Akurit Z Tablet should be used with caution in patients with kidney disease. Dose adjustment of Akurit Z Tablet may be needed. Please consult your doctor.
Akurit Z Tablet should be used with caution in patients with liver disease. Dose adjustment of Akurit Z Tablet may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised before and after the start of the treatment.
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Information last updated by Dr. Varun Gupta, MD Pharmacology on 25th Jan 2018.