Adesure 400mg Tablet


Adesure 400mg Tablet is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.

Adesure 400mg Tablet may be taken with or without food. The dose will depend on the severity of your condition and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

Use of this medicine may cause some common side effects such as headache, dizziness, vomiting, upset stomach, diarrhea, constipation, increased sweating, and insomnia. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea and constipation.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.

Uses of Adesure Tablet

Benefits of Adesure Tablet

In Treatment of Liver disease

Adesure 400mg Tablet protects the liver from damage against harmful chemicals, thereby improving overall health of the liver. This helps the liver to perform its normal functions. To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol.

Side effects of Adesure Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Adesure

  • Headache
  • Dizziness
  • Vomiting
  • Upset stomach
  • Diarrhea
  • Constipation
  • Increased sweating
  • Insomnia (difficulty in sleeping)

How to use Adesure Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adesure 400mg Tablet may be taken with or without food, but it is better to take it at a fixed time.

How Adesure Tablet works

Adesure 400mg Tablet contains S-Adenosyl L-Methoinine Disulfate Tosylate, also known as SAMe, a nutritional supplement, that can restore Glutathione concentrations in the liver and also improves liver damage. SAMe is also involved in many biochemical reactions in the human body that regulate the growth, death and differentiation of hepatocytes (liver cells). Because liver function is compromised in people suffering from liver disease, supplementation with Adesure 400mg Tablet is beneficial.

Safety advice

It is unsafe to consume alcohol with Adesure 400mg Tablet.
Adesure 400mg Tablet is safe to use during pregnancy. Most studies have shown low or no risk to the developing baby.
Breast feeding
Information regarding the use of Adesure 400mg Tablet during breastfeeding is not available. Please consult your doctor.
Adesure 400mg Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
There is limited information available on the use of Adesure 400mg Tablet in patients with kidney disease. Please consult your doctor.
Adesure 400mg Tablet is safe to use in patients with liver disease. No dose adjustment of Adesure 400mg Tablet is recommended.

All substitutes

For informational purposes only. Consult a doctor before taking any medicines.
Adesure 400mg Tablet
Livsam 400mg Tablet
Skyglow Pharmaceuticals Private Limited
7% costlier
Adniva 400 Tablet
Palvin Pharmaceuticals
21% costlier
Samorac 400 Tablet
Vitalae Healthcare
49% costlier
Ederoz 400mg Tablet
Hauz Pharma Pvt Ltd
53% costlier
Samivio Tablet
Wellvio Healthcare Pvt Ltd
71% costlier

Quick tips

  • Adesure 400mg Tablet is prescribed for the treatment of liver disease.
  • Seek immediate medical attention if you have difficulty breathing after taking the drug.
  • Adesure 400mg Tablet may interfere with surgery. Its use should be discontinued at least two weeks prior to surgery.
  • Avoid smoking and drinking as it further degrades liver functioning.
  • You will be regularly monitored for blood creatinine and blood/urine urea levels while on treatment with Adesure 400mg Tablet.

Fact Box

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Patient concerns

Fatty liver disease with enlarged liver
Dr. Aanchal Maheshwari
Take cytozen capsule twice, lavanbhasksr churan half spoon twice
Liver disease due to fatty liver
Dr. Deepak Kumar Soni
Hi kindly share your reports

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.


  1. Guo T, Chang L, Xiao Y, et al. S-adenosyl-L-methionine for the treatment of chronic liver disease: A systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124. [Accessed 02 Jul. 2021] (online) Available from:External Link
  2. Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. World J Hepatol. 2020;12(2):46-63. [Accessed 02 Jul. 2021] (online) Available from:External Link

Manufacturer/Marketer address

Door No.1406, 17-A Main 1 B Cross J.P. Nagar Bangalore Bangalore KA 560078 IN
Country of origin: India

Expires on or after: February, 2023

A licensed vendor partner from your nearest location will deliver Adesure 400mg Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
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