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ADMIN 400 Tablet is a medicine used for the treatment of liver disease associated with reduced bile formation (intrahepatic cholestasis). It protects the liver cells from toxins and helps the liver to perform its normal functions.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Mekhala Chandra, MD, MBBS,
Last updated on 28 Nov 2025 | 11:59 AM (IST)
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General Information

Contains

S-Adenosyl L-Methoinine Disulfate Tosylate (400mg)

Marketer

Sanatra Health Care
The content is shown in English
ADMIN 400 Tablet image
ADMIN 400 Tablet image

Product introduction

ADMIN 400 Tablet may be taken with or without food. The dose will depend on the severity of your condition and your body weight. It is best swallowed whole, but you may need to break them to get the correct dose. This medicine needs to be taken regularly to get the most benefit and you may have to take it for several months or longer, so try to get into a routine. Keep using it as prescribed even if your symptoms disappear.

Use of this medicine may cause some common side effects such as headache, dizziness, vomiting, upset stomach, diarrhea, constipation, and insomnia. Not everyone gets side effects. If you are worried about them, or they do not go away, let your doctor know. If you have problems with diarrhea your doctor may reduce the dose or stop the treatment. Drink enough water or fluids to stay hydrated in case of severe diarrhea and constipation.

Before taking this medicine, you should tell your doctor if you are pregnant, planning pregnancy, or breastfeeding. Using this medicine can reduce or increase the effect of some other medicines so tell your doctor, all other medicines you are taking. Avoid drinking alcohol as it might increase side effects.

Uses of ADMIN Tablet

Benefits of ADMIN Tablet

Treatment of Liver disease
Liver problems can interfere with the body’s ability to remove toxins and digest food properly, leading to fatigue, poor digestion, and overall weakness. ADMIN 400 Tablet supports liver function, helps protect liver cells from damage, and improves their recovery. It aids in maintaining better liver health and reducing complications.

Side effects of ADMIN Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of ADMIN
  • Headache
  • Dizziness
  • Vomiting
  • Upset stomach
  • Diarrhea
  • Constipation
  • Insomnia (difficulty in sleeping)

How to use ADMIN Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. ADMIN 400 Tablet may be taken with or without food.

How ADMIN Tablet works

ADMIN 400 Tablet contains S-Adenosyl L-Methoinine Disulfate Tosylate, also known as SAMe, a nutritional supplement, that can restore Glutathione concentrations in the liver and also improves liver damage. SAMe is also involved in many biochemical reactions in the human body that regulate the growth, death and differentiation of hepatocytes (liver cells). Because liver function is compromised in people suffering from liver disease, supplementation with ADMIN 400 Tablet is beneficial.

All substitutes for ADMIN 400 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Alsame Tablet

by Alniche Life Sciences Pvt Ltd
₹77.6/tablet
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<h3 class=bodySemiBold>Alsame Tablet</h3>

Mednosam 400 Tablet

by Medvik Pharmaceuticals Pvt Ltd
₹70.5/tablet
54% costlier
<h3 class=bodySemiBold>Mednosam 400 Tablet</h3>

ADEBEST 400mg Tablet

by Extimus Healthcare Pvt Ltd
₹68.4/tablet
49% costlier
<h3 class=bodySemiBold>ADEBEST 400mg Tablet</h3>

Samorac 400 Tablet

by Vitalae Healthcare
₹82.7/tablet
81% costlier
<h3 class=bodySemiBold>Samorac 400 Tablet</h3>

Sambrace 400 Tablet

by Rebrace
₹77.7/tablet
70% costlier
<h3 class=bodySemiBold>Sambrace 400 Tablet</h3>

Quick tips

  • ADMIN 400 Tablet is prescribed for the treatment of liver disease.
  • Seek immediate medical attention if you have difficulty breathing after taking the drug.
  • ADMIN 400 Tablet may interfere with surgery. Its use should be discontinued at least two weeks prior to surgery.
  • Avoid smoking and drinking as it further degrades liver functioning.
  • You will be regularly monitored for blood creatinine and blood/urine urea levels while on treatment with ADMIN 400 Tablet.

Safety advice

Alcohol

Alcohol

UNSAFE
It is unsafe to consume alcohol with ADMIN 400 Tablet
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of ADMIN 400 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of ADMIN 400 Tablet during breastfeeding is not available. Please consult your doctor.
Driving

Driving

UNSAFE
ADMIN 400 Tablet may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of ADMIN 400 Tablet in patients with kidney disease. Please consult your doctor.
Liver

Liver

SAFE IF PRESCRIBED
ADMIN 400 Tablet is safe to use in patients with liver disease. No dose adjustment is recommended.

Frequently asked questions

ADMIN 400 Tablet is used to treat liver diseases where bile flow is reduced (intrahepatic cholestasis). It protects liver cells from harmful substances and helps the liver function normally.
ADMIN 400 Tablet is usually used to support liver health, but due to its anti‑inflammatory properties, it can also help reduce pain and improve joint function, similar to common arthritis medicines but with fewer side effects. Your doctor will evaluate the need for this medicine and advise on the dose and duration for the best results.
ADMIN 400 Tablet is usually used to support liver health. However, some people find that it helps improve mood and reduce depression symptoms. Always use this medicine only as prescribed by your doctor.
ADMIN 400 Tablet contains SAMe, which is a natural compound made by the body but can also be taken as a synthetic supplement to increase low levels.
ADMIN 400 Tablet can support liver function and help protect liver cells. Your doctor will prescribe the dose and duration of this medicine for the best results.

Fact Box

Chemical Class

Sulfonium compounds

Habit Forming

No

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

Related lab tests

Bilirubin Direct

Bilirubin Indirect

Bilirubin Total

Liver Function Test

References

  1. Guo T, Chang L, Xiao Y, et al. S-adenosyl-L-methionine for the treatment of chronic liver disease: A systematic review and meta-analysis. PLoS One. 2015;10(3):e0122124. [Accessed 02 Jul. 2021] (online) Available from:
  2. Noureddin M, Sander-Struckmeier S, Mato JM. Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review. World J Hepatol. 2020;12(2):46-63. [Accessed 02 Jul. 2021] (online) Available from:
  3. La Renon: S-Adenosyl-L-methionine (SAMe) [Product Information]. [Accessed 25 Jul. 2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sanatra Health Care
Address: 83/4 Friends Colony, Ballupur Distt Dehradun 248001, Uttarakhand.

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver ADMIN 400 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's â„ž and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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