Adefresh 400 Tablet

Reviewed By Dr. Rajeev Sharma, MBA, MBBS

Last updated on 05 Apr 2026 | 07:41 PM (IST)

Adefresh 400 Tablet is a medicine used in the treatment of intrahepatic cholestasis and other chronic liver diseases. It works by restoring the natural compound in the liver that helps protect liver cells from damage, improves the flow of bile, and supports overall healthy liver function.

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₹868 MRP ₹9509% off

Available in pack-size of 15 tablets

15 tablets pack-size available

Adefresh 400 Tablet

₹1298~~₹1420~~

Available in pack size of 15 tablets

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Adefresh 400 Tablet

strip of 10 tablets

₹868

~~₹950~~

Different pack-size

Adefresh 400 Tablet

strip of 15 tablets

Ademetionine (400mg)

by Sanatra Health Care

Get in 60 mins

₹1298

₹86.53 per tablet

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General Information

Storage

Store below 25°C

The content is shown in English

Product introduction

Adefresh 400 Tablet is usually recommended to be taken before meals, as this improves absorption. The exact dose depends on your body weight and the condition being treated. To get the most benefit, it is important to take this medicine regularly and at the same time each day. Treatment may need to continue for several months or longer, depending on your doctor’s advice. Even if your symptoms improve, do not stop taking it unless your doctor tells you to.

The most common side effects of Adefresh 400 Tablet are nausea, abdominal discomfort, and diarrhea. These effects are usually mild and temporary. If diarrhea becomes bothersome, your doctor may adjust your dose or stop the treatment. Drinking plenty of fluids can help prevent dehydration if you experience diarrhea or constipation. Rarely, some people may also experience a headache, trouble sleeping, or a skin rash. If any side effect worries you, consult with a doctor.

Adefresh 400 Tablet should be used with caution in patients with a history of bipolar disorder, as this medicine may rarely trigger mood swings. Use during pregnancy and breastfeeding should only be under medical advice. This medicine can interact with other drugs, so let your doctor know about all the medicines and supplements you are taking. Avoid drinking alcohol while on treatment, as this may increase the strain on your liver and worsen side effects.

Uses of Adefresh Tablet

Treatment of Liver disease

Benefits of Adefresh Tablet

Treatment of Liver disease
Adefresh 400 Tablet is used in the management of liver disease, including conditions such as intrahepatic cholestasis and chronic liver disorders. It supports the liver’s natural detoxification processes, helps restore antioxidant levels like glutathione, and improves bile flow. It protects liver cells and promotes their healthy function, playing an important role in maintaining overall liver health.

Side effects of Adefresh Tablet

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Adefresh

Nausea
Diarrhea
Abdominal pain

How to use Adefresh Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Adefresh 400 Tablet is to be taken on an empty stomach.

How Adefresh Tablet works

Adefresh 400 Tablet works by helping the liver make and restore important substances that protect its cells. It increases the liver’s natural antioxidants, reduces damage from toxins, and improves the flow of bile. This supports healthier liver function in conditions like intrahepatic cholestasis and chronic liver disease.

All substitutes for Adefresh 400 Tablet

For information purposes only. Consult a doctor before taking any medicine.

Hepadem 400 Tablet

by Zeelab Pharmacy Pvt Ltd

₹29.9/tablet

66% cheaper

HEPtral 400mg Tablet

by Abbott

₹131.9/tablet

52% costlier

Cirrosam 400 Tablet

by La Renon Healthcare Pvt Ltd

₹115.87/tablet

33% costlier

New Nusam 400 Tablet

by Sun Pharmaceutical Industries Ltd

₹86.2/tablet

1% cheaper

Efekart 400mg Tablet

by Crizon Healthcare Pvt Ltd

₹76.2/tablet

12% cheaper

Quick tips

Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if diarrhea persists or if you find blood in your stools.
To make sure it is safe for you, consult with your doctor if you are pregnant, planning pregnancy, or breastfeeding before starting this medicine.
Follow a healthy diet, avoid alcohol, and keep yourself well hydrated to complement the treatment.
Inform your doctor if you have bipolar disorder or a history of mood swings; this medicine may trigger mania/hypomania.
Tell your doctor if you have rare genetic problems affecting methionine metabolism (e.g., homocystinuria).
Your doctor may check vitamin B12 and folate levels during treatment.

Safety advice

Alcohol

CONSULT YOUR DOCTOR

It is not known whether it is safe to consume alcohol with Adefresh 400 Tablet. Please consult your doctor.

Pregnancy

CONSULT YOUR DOCTOR

The safety of Adefresh 400 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
High doses used in late pregnancy have not shown harmful effects. However, in the first trimester, use only if clearly needed, and always under medical supervision.

Breast feeding

CONSULT YOUR DOCTOR

Information regarding the use of Adefresh 400 Tablet during breastfeeding is not available. Please consult your doctor.
Use during breastfeeding only if the expected benefit to the mother outweighs the possible risk to the baby.

Driving

SAFE

Adefresh 400 Tablet does not usually affect your ability to drive.
This medicine may cause dizziness. Do not drive or operate machinery until you know how it affects you.

Kidney

CAUTION

Adefresh 400 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.

Liver

CONSULT YOUR DOCTOR

There is limited data available on the use of Adefresh 400 Tablet in patients with liver disease.

Frequently asked questions

What is Adefresh 400 Tablet used for?

Adefresh 400 Tablet is mainly used for the treatment of intrahepatic cholestasis, a condition in which the flow of bile from the liver is reduced, and in certain liver diseases. It helps improve bile secretion and protect liver cells from damage. This helps relieve symptoms such as itching, tiredness, and digestive discomfort that often occur in these conditions.

How does Adefresh 400 Tablet work in liver disease?

Adefresh 400 Tablet is a natural substance produced in the body that plays an important role in liver health. In people with liver disease, its levels are usually lower than normal. Taking Adefresh 400 Tablet helps restore these levels, which improves bile flow, protects liver cells from harmful toxins and oxidative stress, and supports the liver’s natural detoxification functions. This way it helps the liver work more effectively and reduce the complications associated with cholestasis and other liver problems.

How should Adefresh 400 Tablet be taken?

Take Adefresh 400 Tablet exactly as prescribed by your doctor. The dose and duration of treatment depend on your medical condition, response to treatment, and your doctor’s judgment. Stopping or changing the dose on your own is not advised, as it may affect the effectiveness of treatment.

Is Adefresh 400 Tablet safe during pregnancy or breastfeeding?

Adefresh 400 Tablet should only be used during pregnancy or breastfeeding if it is clearly recommended by your doctor. The safety of this medicine in these conditions has not been fully established, so medical supervision is essential. Always consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding.

Can I take Adefresh 400 Tablet with other medicines?

You should inform your doctor about all other medicines, supplements, or herbal products that you are currently taking. This will help your doctor decide if Adefresh 400 Tablet is safe to use alongside them and will reduce the risk of any possible interactions that could affect your treatment or overall health.

Fact Box

Chemical Class

5'- deoxy- 5'- thionucleosides

Habit Forming

Therapeutic Class

GASTRO INTESTINAL

Action Class

Hepatoprotective Agents

References

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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Sanatra Health Care
Address: 83/4 Friends Colony, Ballupur Distt Dehradun 248001, Uttarakhand.

Vendor Details

Country of origin: India

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Why we need a prescription?

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In accordance with the law

Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945

Adefresh 400 Tablet

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General Information

Contains

Salt Synonyms

Marketer

Storage

Product introduction

Uses of Adefresh Tablet

Benefits of Adefresh Tablet

Side effects of Adefresh Tablet

How to use Adefresh Tablet

How Adefresh Tablet works

All substitutes for Adefresh 400 Tablet

Hepadem 400 Tablet

HEPtral 400mg Tablet

Cirrosam 400 Tablet

New Nusam 400 Tablet

Efekart 400mg Tablet

Quick tips

Safety advice

Alcohol

Pregnancy

Breast feeding

Driving

Kidney

Liver

Frequently asked questions

What is Adefresh 400 Tablet used for?

How does Adefresh 400 Tablet work in liver disease?

How should Adefresh 400 Tablet be taken?

Is Adefresh 400 Tablet safe during pregnancy or breastfeeding?

Can I take Adefresh 400 Tablet with other medicines?

Fact Box

Chemical Class

Habit Forming

Therapeutic Class

Action Class

References

Want to know more

Have issue with the content

Disclaimer

Marketer details

Vendor Details

Lab tests offered by us

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