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Ryzodeg 100 unit/ml Penfill (3ml Each)

Insulin Degludec (2.56mg/ml)+ Insulin Aspart (1.05mg/ml)
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Stored between 2-8°C
Ryzodeg 100 unit/ml Penfill (3ml Each) is a combination of two medicines, a long-acting and a rapid-acting type of insulin, used to treat types 1 and 2 diabetes mellitus in both adults and children. It provides a steady level of insulin in the body for an entire day and helps control blood sugar levels.

Written By Dr. Sakshi Jain, MS, BDS,
Reviewed By Dr. Rajeev Sharma, MBA, MBBS,
Last updated on 03 Dec 2025 | 12:44 PM (IST)
₹5772 MRP ₹61937% off 
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General Information

The content is shown in English
Ryzodeg 100 unit/ml Penfill (3ml Each) image
Ryzodeg 100 unit/ml Penfill (3ml Each) image
Ryzodeg 100 unit/ml Penfill (3ml Each) image

Product introduction

Ryzodeg 100 unit/ml Penfill (3ml Each) can be prescribed by itself or along with other diabetes medicines. Your doctor or nurse will teach you how to inject it under the skin correctly. You should use this medicine regularly as per the dose advised to get the most benefit. It is usually taken once daily at the same time every day. However, when administration at the same time of the day is not possible, it may be taken at a different time. Always ensure that there is a minimum gap of 8 hours between doses. 

If you stop taking it, your blood sugar levels may rise very high and put you at risk of serious complications. It is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction, as your doctor advises.

This medicine's most common side effect is low blood sugar levels (hypoglycemia). To prevent this, it is important always to inject the correct dose of medicine only, have regular meals, and monitor your blood sugar levels regularly. Drinking excessive alcohol can also lead to a fall in your blood sugar levels. Other common side effects include allergic reactions, injection site reactions, lipodystrophy, itching, rash, edema, and weight gain.

Do not use this medicine when you have low blood sugar levels (hypoglycemia). Tell your doctor if you have ever had kidney, liver, or heart problems before starting treatment. Pregnant or breastfeeding women should also consult their doctor before using it.

Uses of Ryzodeg Cartridge

Benefits of Ryzodeg Cartridge

Treatment of Diabetes
Ryzodeg 100 unit/ml Penfill (3ml Each) combines long-acting insulin degludec and rapid-acting insulin aspart to provide flexible and convenient blood sugar control in patients with diabetes. The long-acting component helps maintain steady insulin levels throughout the day and night, while the rapid-acting insulin manages blood sugar spikes after meals. This reduces the number of injections needed, improves glycemic control, and helps lower the risk of hypoglycemia (low blood sugar), especially at night, making it a highly effective option for people with diabetes.

Side effects of Ryzodeg Cartridge

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Ryzodeg
  • Injection site reactions (pain, swelling, redness)
  • Lipodystrophy (skin thickening or pits at the injection site)
  • Itching
  • Rash
  • Edema (swelling)
  • Weight gain
  • Hypoglycemia (low blood glucose level)

How to use Ryzodeg Cartridge

Your doctor or nurse will give you this medicine. You or your care giver may be taught on how to use this medicine at home.

How Ryzodeg Cartridge works

Insulin degludec and insulin aspart. Insulin degludec has a prolonged duration of action while insulin aspart has a fast onset of action. Together, they ensure rapid and consistent sugar control by facilitating reuptake of sugar in muscle and fat cells, and suppressing the production of sugar in the liver.

Quick tips

  • Take it 15 minutes before or within 20 minutes after starting a meal.
  • Injection below the skin of the abdomen results in faster absorption than other injection sites, such as the skin of the upper arms, thighs, or buttocks. After injection, the site of injection should not be massaged.
  • Injection sites must be rotated to prevent hard lumps from developing at one site.
  • Change to another type or brand of insulin should be done under strict medical supervision as it may require a change in dosage.
  • Hypoglycemia (low blood sugar level) may occur when taken along with other antidiabetic medicines, alcohol, or by delaying/skipping a meal. Carry a sugar source with you for immediate relief.
  • Do not share your insulin device with others, even if the needle has been changed. You may give other people a serious infection or get it from them.
  • Opened vials/cartridges can be kept at room temperature for up to 4 weeks, while unopened vials must be stored in the refrigerator (2°C–8°C).

Safety advice

Alcohol

Alcohol

CAUTION
Alcohol should be used with caution while taking Ryzodeg 100 unit/ml Penfill (3ml Each).
Pregnancy

Pregnancy

SAFE IF PRESCRIBED
Ryzodeg 100 unit/ml Penfill (3ml Each) is generally considered safe to use during pregnancy. Animal studies do not indicate harmful effects. However, there are limited human studies.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Ryzodeg 100 unit/ml Penfill (3ml Each) may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

UNSAFE
Ryzodeg 100 unit/ml Penfill (3ml Each) may decrease alertness, affect your vision, or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
Kidney

Kidney

CAUTION
Ryzodeg 100 unit/ml Penfill (3ml Each) should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Liver

Liver

CAUTION
Ryzodeg 100 unit/ml Penfill (3ml Each) should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Ryzodeg 100 unit/ml Penfill (3ml Each) is a combination of two types of insulin: insulin degludec (long-acting) and insulin aspart (rapid-acting). It is used to help control blood sugar levels in people with diabetes.
Ryzodeg 100 unit/ml Penfill (3ml Each) works by mimicking the natural insulin produced by the pancreas. Insulin aspart helps manage blood sugar levels after meals, while insulin degludec provides a steady release of insulin to control blood sugar between meals and overnight.
Ryzodeg 100 unit/ml Penfill (3ml Each) is prescribed for adults, adolescents, and children over 2 years old with Type 1 or Type 2 diabetes who require insulin to manage their blood sugar levels.
Ryzodeg 100 unit/ml Penfill (3ml Each) should be injected under the skin (subcutaneously) using a compatible insulin delivery device (pen). It is typically administered once or twice daily, with at least one dose given with a main meal. Follow your doctor's instructions on dosage and timing.
No, Ryzodeg 100 unit/ml Penfill (3ml Each) should not be mixed with other insulins. Follow the exact prescription instructions. Avoid combining it with other insulin products in the same injection.
Store Ryzodeg 100 unit/ml Penfill (3ml Each) in a refrigerator between 2°C and 8°C. Do not freeze it. After opening, the pen can be stored at room temperature for up to 28 days. Keep it away from direct heat and sunlight.
If you are pregnant or planning to become pregnant, consult your doctor before using Ryzodeg 100 unit/ml Penfill (3ml Each). It is important to maintain good blood sugar control during pregnancy. If you are breastfeeding, your doctor will determine if Ryzodeg 100 unit/ml Penfill (3ml Each) is suitable for you.
An overdose of Ryzodeg 100 unit/ml Penfill (3ml Each) can cause hypoglycemia (low blood sugar). Symptoms may include dizziness, confusion, sweating, and shakiness. If you suspect an overdose, consume sugar or a sugary snack, and contact your healthcare provider immediately.
Yes, Ryzodeg 100 unit/ml Penfill (3ml Each) is approved for use in children over 2 years of age who have diabetes. The dosage for children will depend on individual needs, as determined by the doctor.
Yes, regular blood sugar monitoring is essential when using Ryzodeg 100 unit/ml Penfill (3ml Each). Your doctor will guide you on how often you should check your levels and adjust your insulin dose if necessary.
Allergic reactions to insulin are rare, but if you experience symptoms such as rash, itching, difficulty breathing, or swelling of the face or throat, seek medical help immediately.

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ANTI DIABETIC
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: Novo Nordisk India Pvt Ltd
Address: Plot No.32, 47-50, EPIP Area, Whitefield, Bangalore - 560 066

Vendor Details

Country of origin: Denmark
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