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Lioton 500 Gel

Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Mekhala Chandra, MD, MBBS
Last updated on 07 Apr 2026 | 03:08 PM (IST)
Lioton 500 Gel is an anticoagulant that prevents blood clotting. It is applied to the skin for the treatment of superficial thrombophlebitis (inflammation of a vein caused by a blood clot), bruises, and varicose veins. It speeds up the formation of blood clots and decreases pain and swelling.
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General Information

Contains

Heparin (500IU/gm)

Marketer

A. Menarini India Pvt Ltd

Storage

Store below 25°C
The content is shown in English
Lioton 500 Gel image
Lioton 500 Gel image
Lioton 500 Gel image
Lioton 500 Gel image
Lioton 500 Gel image
Lioton 500 Gel image
Lioton 500 Gel image

Product introduction

Use Lioton 500 Gel as advised by your doctor. This medicine is meant for external use only. It should be applied only to the affected area of the skin as per the dosage and schedule prescribed by your doctor. To get the most benefit, apply it regularly. Do not use larger amounts, apply it more often, or use it for a longer duration than directed. This will only increase the risk of side effects.

Local side effects, such as rashes, may occur after application. This is usually temporary and resolves quickly. Avoid any contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the medicine in these areas. Consult your doctor if you experience any symptoms that bother you or if your condition does not improve.

Do not use Lioton 500 Gel if you are allergic to heparin or any of its ingredients. Use with caution in conditions such as hemorrhagic edema, as close monitoring may be required. Pregnant and breastfeeding women should let their doctor know to make sure it is safe for them.

Uses of Lioton Gel

  • Prevention of Blood clots

Benefits of Lioton Gel

Prevention of Blood clots
Formation of blood clots blocks one or more veins, usually in your legs. Lioton 500 Gel is used to prevent formation of blood clots near the surface of your skin. It dissolves the clots and also relieves pain and inflammation by increasing the blood flow. This improves the overall healing process.
Use it as advised by the doctor to get maximum benefit. The condition usually improves on its own in sometime. However, your doctor might recommend applying heat to the painful area, elevating the affected leg, using an over-the-counter painkiller and possibly wearing compression stockings.

Side effects of Lioton Gel

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Lioton
  • Skin rash

How to use Lioton Gel

This medicine is for external use only. Use it in the dose and duration as advised by your doctor. Check the label for directions before use. Clean and dry the affected area and apply the gel. Wash your hands after applying, unless hands are the affected area.

How Lioton Gel works

Lioton 500 Gel is an anticoagulant. It penetrates into the diseased tissue immediately upon application without leaving residues or degreasing the skin. This helps in strengthening and supporting the connective tissues, thus alleviating pain and speeding up healing.

Quick tips

  • Apply Lioton 500 Gel only to the affected area as instructed by your doctor.
  • Wash your hands with soap before and after applying Lioton 500 Gel to prevent accidental contact with other areas.
  • Apply a thin layer of Lioton 500 Gel and spread it gently without vigorous rubbing.
  • Use Lioton 500 Gel only on intact skin and avoid applying it on open wounds, cuts, or near the eyes, nose, or mouth.
  • Lioton 500 Gel may make your skin more sensitive to sunlight, so use sunscreen or protective clothing when going outdoors.
  • Stop using Lioton 500 Gel and consult your doctor if you notice itching, rash, or irritation at the application site.
  • This medicine is meant for surface vein or local skin conditions and cannot treat deep vein problems such as deep vein thrombosis (DVT).
  • If you experience severe swelling, warmth in the leg, or sudden chest pain, seek immediate medical attention.

Safety advice

Alcohol

Alcohol

No interaction found/established
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Lioton 500 Gel during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

SAFE IF PRESCRIBED
Lioton 500 Gel may be safe to use during breastfeeding. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Driving

Driving

No interaction found/established
Kidney

Kidney

No interaction found/established
Liver

Liver

No interaction found/established

Interaction with drugs

Taking Lioton with any of the following medicines can modify the effect of either of them and cause some undesirable side effects
Mild

Argatroban (Injection Route)

Inform your doctor if you notice any signs of bleeding (bruising, bleeding gums, blood in stool/vomit/urine).

Frequently asked questions

Lioton 500 Gel is a medicated gel that contains heparin, a substance that belongs to a group of medicines called anticoagulants. These medicines help prevent blood clots from forming. When applied to the skin, Lioton 500 Gel works locally at the affected area. It helps reduce inflammation and swelling linked to superficial vein conditions. By acting at the site of application, it supports the natural healing process in areas affected by clot-related vein inflammation.
It is important to use Lioton 500 Gel exactly as advised by your doctor or pharmacist. Even if your symptoms begin to improve, you should not stop treatment without medical advice. The length of treatment depends on the type and severity of your condition. If your symptoms do not improve or become worse, speak to your healthcare professional for further guidance.
Lioton 500 Gel should only be applied to intact, unbroken skin. It should not be used on open wounds, cuts, infected areas, or damaged skin. Avoid contact with the eyes, mouth, and other mucous membranes. Wash your hands after applying the gel, unless your hands are the area being treated. If you have a bleeding disorder or notice any unusual skin reactions, such as irritation or rash, stop using the gel and seek medical advice.
Lioton 500 Gel is used to relieve symptoms associated with superficial thrombophlebitis and related vein conditions. Its active ingredient, heparin, acts locally to help reduce inflammation and support clot management at the site of application. The response to treatment can vary from person to person, and it should be used as directed by a healthcare professional.
Since Lioton 500 Gel contains heparin, which affects blood clotting, caution is advised in people with bleeding disorders. However, when applied to the skin as directed, it works locally, and the risk of bleeding is generally low. If you notice any unusual bruising or bleeding, contact your doctor promptly.
Before using Lioton 500 Gel, inform your doctor if you are taking medicines that affect blood clotting, such as oral anticoagulants. Even though the gel is applied to the skin, your healthcare provider must be aware of all medicines you are using. This helps ensure safe and appropriate treatment.
The time it takes to notice improvement can vary depending on the severity of your condition. Relief may be felt as swelling and discomfort gradually reduce. If your symptoms do not improve within a few days or worsen, you should consult your doctor.
No, Lioton 500 Gel should not be applied to open wounds, cuts, infected skin, or damaged areas. It is meant for use only on intact skin. Applying it to broken skin may increase the risk of irritation or other unwanted effects.
If you are pregnant or breastfeeding, you should consult your doctor before using Lioton 500 Gel. It should only be used during pregnancy if clearly necessary and under medical advice.
If you are taking oral anticoagulants or other blood-thinning medicines, inform your doctor before using Lioton 500 Gel. Although it works locally on the skin, your doctor will decide whether it is appropriate for you based on your overall treatment plan.
Lioton 500 Gel is used for superficial vein conditions, including inflammation of veins associated with clot formation. It may help relieve related symptoms such as swelling and discomfort. However, it does not remove or cure varicose veins. A doctor can guide you on suitable treatment options for varicose veins.
Lioton 500 Gel is indicated for conditions related to superficial vein inflammation and clot-associated symptoms. It is not specifically indicated for general muscle pain. If you are experiencing muscle discomfort, it is advisable to consult a healthcare professional for appropriate advice.
Common warning signs of a blood clot may include swelling in one limb, pain or tenderness in the affected area, redness or skin discoloration, warmth over the area, and sudden shortness of breath or chest pain. These symptoms can indicate a serious medical condition. Immediate medical attention is important if such symptoms occur.

Fact Box

Chemical Class

Glycosaminoglycans

Habit Forming

No

Therapeutic Class

BLOOD RELATED

Action Class

Unfractionated Heparin (UFH)

References

  1. Weitz JI. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. pp. 853-59.
  2. Zehnder JL. Drugs Used in Disorders of Coagulation. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. pp. 591-93.
  3. Fox KA, White HD, Gersh BJ, et al. Antithrombotic Agents: Platelete Inhibitors, Acute Anticoagulants, Fibrinolytics, and Chronic Anticoagulants. In: Opie LH, Gersh BJ, editors. Drugs for the Heart. 8th ed. Philadelphia, Pennsylvania: Elsevier Saunders; 2013. pp. 367-73.
  4. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. pp. 652-53.
  5. Central Drugs Standard Control Organisation (CDSCO). Heparin. [Accessed 18 Mar. 2019] (online) Available from:
  6. Heparin sodium. Florence, Italy: A. Menarini Industrie Farmaceutiche Riunite S.r.l.; [Accessed 05 Jan. 2026] (online). Available from:
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Manufacturer details

Name: A)Akums Drugs & Pharmaceuticals Ltd.
Address: A)47, 48, Sector-6A, I.I.E., SIDCUL, Haridwar-249 403, Uttarakhand, India.

Marketer details

Name: A. Menarini India Pvt Ltd
Address: 2102, Tower 3, Indiabulls Finance Center, Senapati Bapat Marg, Elphinstone Road (west), Mumbai - 400013

Vendor Details

Country of origin: India

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