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Koselugo 10mg Capsule

Selumetinib (10mg)
Genuine
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₹367876
₹408796.88
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60 capsules
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General Information

Contains

Selumetinib (10mg)

Marketer

AstraZeneca

Storage

Store below 30°C
The content is shown in English
Koselugo 10mg Capsule image
Koselugo 10mg Capsule image

Uses of Koselugo Capsule

  • Treatment of Neurofibromatosis type 1 (NF1)

Benefits of Koselugo Capsule

Treatment of Neurofibromatosis type 1 (NF1)
Koselugo 10mg Capsule is used to treat children aged 2 years and above with neurofibromatosis type 1 (NF1), particularly those with symptomatic, inoperable tumors. Koselugo 10mg Capsule helps slow tumor growth and reduce the size of tumors. This results in reduced pain, improved physical function, and decreased disfigurement caused by these benign growths. This improvement in tumor size and symptoms can improve mobility and reduce the need for invasive surgeries. When taken in the right dose and duration, Koselugo 10mg Capsule helps improve the overall quality of life for patients and allows them to engage more fully in daily activities with less discomfort.

Side effects of Koselugo Capsule

Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Koselugo
  • Headache
  • Paronychia
  • Itching
  • Vomiting
  • Rash
  • Abdominal pain
  • Diarrhea
  • Nausea
  • Dry skin
  • Fatigue
  • Musculoskeletal (bone, muscle or joint) pain
  • Fever
  • Stomatitis (Inflammation of the mouth)

How to use Koselugo Capsule

Take this medicine in the dose and duration as advised by your doctor. Koselugo 10mg Capsule may be taken with or without food.

How Koselugo Capsule works

Koselugo 10mg Capsule works by blocking a protein called MEK, which is part of a system in the body that controls cell growth. In neurofibromatosis type 1 (NF1), this system can become too active because of a genetic change, causing tumors called plexiform neurofibromas to grow. By turning off MEK, Koselugo 10mg Capsule helps slow down or shrink these tumors, reducing symptoms like pain or difficulty moving, and improving the patient’s daily life.

Quick tips

  • Take Koselugo 10mg Capsule exactly as prescribed and at the same time each day for maximum benefits.
  • Inform your doctor about all the medicines and supplements you are taking, and any preexisting medical conditions, to make sure it is safe for you.
  • Drink plenty of water and stay hydrated to manage nausea or diarrhea, and rest a good rest if you feel tired.
  • Make sure to attend all scheduled check-ups for blood tests and heart evaluations to track your progress and detect any potential issues early.
  • If you are of childbearing age, use reliable contraception during treatment and for a period of 1 week after stopping Koselugo 10mg Capsule.

Safety advice

Alcohol

Alcohol

CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Koselugo 10mg Capsule. Please consult your doctor.
Pregnancy

Pregnancy

CONSULT YOUR DOCTOR
The safety of Koselugo 10mg Capsule during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.
Breast feeding

Breast feeding

CONSULT YOUR DOCTOR
Information regarding the use of Koselugo 10mg Capsule during breastfeeding is not available. Please consult your doctor.
Due to the potential for side effects in a breastfed child, advise women not to breastfeed during treatment with Koselugo 10mg Capsule and for 1 week after the last dose.
Driving

Driving

CONSULT YOUR DOCTOR
It is not known whether Koselugo 10mg Capsule alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Please consult your doctor.
Patients may experience fatigue and visual disturbances during treatment with Koselugo 10mg Capsule, do not drive or operate heavy machinery if you experience such symptoms.
Kidney

Kidney

CONSULT YOUR DOCTOR
There is limited data available on the use of Koselugo 10mg Capsule in patients with kidney disease. Please consult your doctor.
Liver

Liver

CAUTION
Koselugo 10mg Capsule should be used with caution in patients with liver disease. Dose adjustment may be needed.

Frequently asked questions

Koselugo 10mg Capsule is used to treat children aged 2 years and older with neurofibromatosis type 1 (NF1). It is specifically prescribed for symptomatic, inoperable plexiform neurofibromas—benign tumors that can cause pain, disfigurement, or other complications.
Take Koselugo 10mg Capsule exactly as prescribed by your doctor. It may be taken with or without food. Swallow the capsules whole with water; do not crush or chew them.
Some medicines and supplements may interact with Koselugo 10mg Capsule, affecting how it works or increasing side effects. Let your doctor know about all the medicines you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
Koselugo 10mg Capsule can harm an unborn baby and is not recommended during pregnancy. If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor. Effective contraception should be used during treatment and for 1 week after the last dose.
Your doctor will perform regular check-ups, including blood tests and heart function evaluations, to ensure the medication is working and to monitor for potential side effects. These tests help adjust the dosage if needed and ensure your safety.
Koselugo 10mg Capsule is not a cure for NF1. It is a treatment to help manage symptoms, reduce the tumor size, and improve the quality of life for patients.
The duration of treatment depends on how your body responds to the medicine. Your doctor will regularly assess your progress and decide the best course of action.
While on treatment with Koselugo 10mg Capsule, avoid St. John’s wort, grapefruit, or grapefruit juice. Additionally, avoid activities that might increase your risk of infection or injury. Be cautious if you have underlying liver or heart conditions, and keep your doctor informed of any changes in your health.
Koselugo 10mg Capsule is primarily approved for children aged two years and older. Adults with NF1 should consult their doctor to determine if this treatment is appropriate for them.

Fact Box

Chemical Class

Benzimidazoles

Habit Forming

No

Action Class

MEK inhibitor

References

  1. Selumetinib [Prescribing Information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024. [Accessed 19/12/2024] (online) Available from:
  2. Selumetinib [Product Monograph]. Mississauga, Ontario: AstraZeneca Canada Inc.; 2022. [Accessed 19/12/2024] (online) Available from:
  3. AstraZeneca Rare Disease. Selumetinib [Information Guide]. 2022. [Accessed 19/12/2024] (online) Available from:
  4. AstraZeneca Rare Disease. Selumetinib [Information Guide]. 2022. [Accessed 19/12/2024] (online) Available from:
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Disclaimer

Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Marketer details

Name: AstraZeneca
Address: Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore

Vendor Details

Country of origin: India
A licensed vendor partner from your nearest location will deliver Koselugo 10mg Capsule. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.

In case of any issues, contact us

Email ID: [email protected]
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India

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Why we need a prescription?
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Provide right medicines
Prescriptions are complex documents. We proof read and recheck at various steps to provide you the right medication in the correct form and dose
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In accordance with the law
Most medicines cannot be sold without a valid prescription, as per the Drugs and Cosmetics Act, 1940 and Rules, 1945
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