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Selumetinib
INFORMATION ABOUT SELUMETINIB
Selumetinib Uses
Selumetinib is used in the treatment of neurofibromatosis type 1 (NF1).
How Selumetinib works
Selumetinib works by blocking a protein called MEK, which is part of a system in the body that controls cell growth. In neurofibromatosis type 1 (NF1), this system can become too active because of a genetic change, causing tumors called plexiform neurofibromas to grow. By turning off MEK, Selumetinib helps slow down or shrink these tumors, reducing symptoms like pain or difficulty moving, and improving the patient’s daily life.
Common side effects of Selumetinib
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common
Vomiting, Rash, Abdominal pain, Diarrhea, Nausea, Dry skin, Fatigue, Musculoskeletal (bone, muscle or joint) pain, Fever, Stomatitis (Inflammation of the mouth), Headache, Paronychia, Itching
CONTENT DETAILS
Written By
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed By
Dr. Rajeev Sharma
MBA, MBBS
Last updated
29 May 2025 | 09:21 AM (UTC)
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Medicine brands for Selumetinib
Koselugo
₹408796 to ₹1021992
AstraZeneca
2 variant(s)
Expert advice for Selumetinib
  • Take Selumetinib exactly as prescribed and at the same time each day for maximum benefits.
  • Inform your doctor about all the medicines and supplements you are taking, and any preexisting medical conditions, to make sure it is safe for you.
  • Drink plenty of water and stay hydrated to manage nausea or diarrhea, and rest a good rest if you feel tired.
  • Make sure to attend all scheduled check-ups for blood tests and heart evaluations to track your progress and detect any potential issues early.
  • If you are of childbearing age, use reliable contraception during treatment and for a period of 1 week after stopping Selumetinib.
Frequently asked questions for Selumetinib
Selumetinib is used to treat children aged 2 years and older with neurofibromatosis type 1 (NF1). It is specifically prescribed for symptomatic, inoperable plexiform neurofibromas—benign tumors that can cause pain, disfigurement, or other complications.
Take Selumetinib exactly as prescribed by your doctor. It may be taken with or without food. Swallow the capsules whole with water; do not crush or chew them.
Some medicines and supplements may interact with Selumetinib, affecting how it works or increasing side effects. Let your doctor know about all the medicines you are taking, including over-the-counter drugs, vitamins, and herbal supplements.
Selumetinib can harm an unborn baby and is not recommended during pregnancy. If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your doctor. Effective contraception should be used during treatment and for 1 week after the last dose.
Your doctor will perform regular check-ups, including blood tests and heart function evaluations, to ensure the medication is working and to monitor for potential side effects. These tests help adjust the dosage if needed and ensure your safety.
Selumetinib is not a cure for NF1. It is a treatment to help manage symptoms, reduce the tumor size, and improve the quality of life for patients.
The duration of treatment depends on how your body responds to the medicine. Your doctor will regularly assess your progress and decide the best course of action.
While on treatment with Selumetinib, avoid St. John’s wort, grapefruit, or grapefruit juice. Additionally, avoid activities that might increase your risk of infection or injury. Be cautious if you have underlying liver or heart conditions, and keep your doctor informed of any changes in your health.
Selumetinib is primarily approved for children aged two years and older. Adults with NF1 should consult their doctor to determine if this treatment is appropriate for them.