Amoxyclav 375 Tablet
Written By Dr. Swati Mishra, BDS
Reviewed By Dr. Rajeev Sharma, MBA, MBBS
Last updated on 01 Apr 2026 | 05:21 PM (IST)
Amoxyclav 375 Tablet is an antibiotic that helps your body fight infections caused by bacteria. It treats infections of the lungs (e.g., pneumonia), the ear, the nasal sinus, the urinary tract, the skin, and the soft tissue. It will not work for viral infections such as the common cold.
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General Information
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Product introduction
Amoxyclav 375 Tablet is best taken with a meal to reduce the chance of stomach upset. Take it regularly at evenly spaced intervals as prescribed by your doctor. Take it at the same time daily to help you remember. The dose will depend on the type and severity of the condition, as well as your body weight. Complete the full course of treatment. Do not stop taking it, even if you feel better. If you stop it early, some bacteria may survive, and the infection may return or worsen.
The most common side effects of Amoxyclav 375 Tablet include recurrent or persistent fungal infection (mucocutaneous candidiasis), nausea, diarrhea, and vomiting. If you experience any symptoms that are persistent or get worse, consult your doctor.
Before taking Amoxyclav 375 Tablet, let your doctor know if you are allergic to any antibiotics or have kidney or liver problems. You should also inform your doctor about all other medicines you are taking, as they may affect or be affected by Amoxyclav 375 Tablet. Pregnant and breastfeeding women should consult their doctor before taking this medicine to make sure it is safe for them.
The most common side effects of Amoxyclav 375 Tablet include recurrent or persistent fungal infection (mucocutaneous candidiasis), nausea, diarrhea, and vomiting. If you experience any symptoms that are persistent or get worse, consult your doctor.
Before taking Amoxyclav 375 Tablet, let your doctor know if you are allergic to any antibiotics or have kidney or liver problems. You should also inform your doctor about all other medicines you are taking, as they may affect or be affected by Amoxyclav 375 Tablet. Pregnant and breastfeeding women should consult their doctor before taking this medicine to make sure it is safe for them.
Uses of Amoxyclav Tablet
- Treatment of Bacterial infections : These include respiratory tract infections (pneumonia, bronchitis), sinus infections (sinusitis), ear infections (otitis media), skin infections (cellulitis), bone and joint infections (osteomyelitis), and dental infections (dental abscess).
Benefits of Amoxyclav Tablet
Treatment of Bacterial infections
Bacterial infections can affect different parts of the body, such as the ear, sinus, throat, lungs, urinary tract, skin, teeth, joints, and bones. Amoxyclav 375 Tablet is an antibiotic that works by killing the bacteria causing the infection. This helps relieve symptoms, clear the infection, and prevent it from spreading or worsening. Complete the full prescribed course to ensure effective treatment and reduce the risk of resistance.
Bacterial infections can affect different parts of the body, such as the ear, sinus, throat, lungs, urinary tract, skin, teeth, joints, and bones. Amoxyclav 375 Tablet is an antibiotic that works by killing the bacteria causing the infection. This helps relieve symptoms, clear the infection, and prevent it from spreading or worsening. Complete the full prescribed course to ensure effective treatment and reduce the risk of resistance.
Side effects of Amoxyclav Tablet
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of Amoxyclav
- Mucocutaneous candidiasis
- Diarrhea
- Nausea
- Vomiting
How to use Amoxyclav Tablet
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Amoxyclav 375 Tablet should be taken with or after food.
How Amoxyclav Tablet works
Amoxyclav 375 Tablet is a combination of two medicines: Amoxycillin and Clavulanic Acid. Amoxycillin is an antibiotic. It works by preventing the formation of the bacterial protective covering, which is essential for the survival of bacteria. Clavulanic Acid is a beta-lactamase inhibitor that reduces resistance and enhances the activity of Amoxycillin against bacteria.
All substitutes for Amoxyclav 375 Tablet
For information purposes only. Consult a doctor before taking any medicine.
Omniclav 375 Tablet
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Quick tips
- Take Amoxyclav 375 Tablet, preferably with food, to avoid stomach upset.
- Stick to simple meals, avoid fatty or spicy food, and drink plenty of water while taking this medicine.
- Do not take antacids 2 hours before or after taking this medicine.
- Diarrhea may occur as a side effect. Taking probiotics along with this medicine may help.
- Seek medical advice if diarrhea becomes severe or persistent, or if you notice bloody stools or develop abdominal cramps.
- Stop taking Amoxyclav 375 Tablet and seek urgent medical attention if you develop a rash, itching, swelling of the face or throat, or difficulty breathing.
- Do not use leftover medicine to treat any future infection. Always consult your doctor before taking any antibiotic.
- Inform your doctor if you have kidney or liver disease before taking Amoxyclav 375 Tablet.
- Complete the full course of treatment and do not stop it early, even if you start feeling better.
Safety advice

Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with Amoxyclav 375 Tablet. Please consult your doctor.

Pregnancy
CONSULT YOUR DOCTOR
The safety of Amoxyclav 375 Tablet during pregnancy has not been established. There are no adequate and well-controlled studies in pregnant women, and animal data on reproductive toxicity are insufficient. Your doctor will weigh the benefits and any potential risks before prescribing.

Breast feeding
CAUTION
Amoxyclav 375 Tablet should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from the body.

Driving
UNSAFE
Amoxyclav 375 Tablet may cause side effects that could affect your ability to drive.
Amoxyclav 375 Tablet may cause side effects such as allergic reactions, dizziness, or fits that may make you unfit to drive.
Amoxyclav 375 Tablet may cause side effects such as allergic reactions, dizziness, or fits that may make you unfit to drive.

Kidney
CAUTION
Amoxyclav 375 Tablet should be used with caution in patients with kidney disease. Dose adjustment may be needed.
Use of this medicine is not recommended in patients with severe kidney disease.
Use of this medicine is not recommended in patients with severe kidney disease.

Liver
CAUTION
Amoxyclav 375 Tablet should be used with caution in patients with liver disease. Dose adjustment may be needed.
Regular monitoring of liver function tests is recommended while you are taking this medicine
Regular monitoring of liver function tests is recommended while you are taking this medicine
Frequently asked questions
Amoxyclav 375 Tablet is an oral antibacterial combination of amoxicillin and clavulanic acid. It is used to treat a wide range of bacterial infections. It is commonly prescribed to treat infections such as ear infections (otitis media), sinus infections (bacterial rhinosinusitis), respiratory infections (pneumonia, bronchitis), and skin and soft tissue infections (cellulitis, abscesses).
Since Amoxyclav 375 Tablet is a penicillin-type antibiotic, individuals with a known penicillin allergy may be at higher risk of an allergic reaction. Patients who are allergic to penicillin or who have had a previous allergic reaction to Amoxyclav 375 Tablet should not use it.
Amoxyclav 375 Tablet should be used with caution in patients with liver disease or a history of jaundice. Dose adjustment may be needed. Your doctor will decide whether to prescribe this medicine after evaluating your condition, often with liver function tests. Always take it only after consulting your doctor.
As per the most recent evidence, Amoxyclav 375 Tablet does not interfere with hormonal birth control. However, talk to your doctor if you have any concerns. They can help you feel confident and protected. Antibiotics such as Amoxyclav 375 Tablet can cause nausea, vomiting, and diarrhea. If you vomit within two hours of taking the birth control pills, or if you have had diarrhea for 24 hours or more, your birth control pills may be ineffective. You may need to use an additional barrier method (such as condoms) in such cases.
No. It is very important to complete the full course of treatment, even if you start feeling better before finishing it. Feeling better does not necessarily mean that all the bacteria causing your infection have been eliminated. Stopping antibiotic treatment early may cause the symptoms to recur or make the bacteria resistant to the antibiotic.
Yes, diarrhea or loose motions is amongst the most commonly reported side effects of Amoxyclav 375 Tablet. In most cases, this is mild and resolves once the antibiotic course is complete. If you develop severe diarrhea, bloody stools, or abdominal cramping, or if symptoms persist or worsen, inform your doctor immediately.
No. Amoxyclav 375 Tablet is an antibiotic and works only against bacterial infections. Viruses cause the common cold and influenza (flu). Antibiotics are not effective against them. If you have a cold or flu, supportive care such as rest, staying hydrated, and using home remedies like saline gargles or steam inhalation may help with recovery.
Amoxyclav 375 Tablet begins to work against bacterial infections within hours of taking it. However, it may take 24 to 48 hours to notice improvement in your symptoms. If you do not notice any improvement, or if your symptoms worsen at any point, contact your doctor. This may indicate that the bacteria causing the infection are resistant to this antibiotic or that a different treatment is needed.
Special care is needed when Amoxyclav 375 Tablet is given to older adults, particularly those with reduced kidney function (renal impairment). The kidneys primarily clear Amoxyclav 375 Tablet from the body, so if they are not functioning well, the drug can build up in the body and increase the risk of side effects. Dose adjustment may be required based on kidney function.
Amoxycillin + Clavulanic Acid is available as a dry powder (dry syrup) that needs to be mixed with water before use. Proper preparation and storage are essential to ensure the medicine works correctly. Always refrigerate the reconstituted suspension (2°C–8°C). Shake well before each use, and discard it within 7–10 days after reconstitution.
Amoxyclav 375 Tablet fights infections caused by bacteria, specifically those that produce enzymes called beta-lactamases. These enzymes are a common mechanism by which bacteria defend themselves against antibiotics. Clavulanic acid blocks these enzymes, allowing amoxicillin to kill the bacteria effectively. This medicine is active against a broad range of bacteria, including both gram-positive and gram-negative types. Common bacteria it targets include Streptococcus pneumoniae (a cause of pneumonia and ear infections), Haemophilus influenzae (associated with respiratory and ear infections), and Moraxella catarrhalis (common in sinus and chest infections).
Fact Box
Habit Forming
No
Therapeutic Class
ANTI INFECTIVES
Related lab tests
References
- Amoxicillin/clavulanate potassium. Research Triangle Park, North Carolina: GlaxoSmithKline. [Accessed 25 Jan. 2019] (online) Available from:
- Amoxicillin and clavulanic acid. Mayenne, France: Glaxo Wellcome Production; 2017. [Accessed 01 Feb. 2019] (online) Available from:
- Amoxicillin trihydrate and potassium clavulanate [EMC SmPC]. London, UK: GlaxoSmithKline UK; 2025. [Accessed 02 Jul. 2025] (online) Available from:
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User feedback
Thrice A Day
50%
Twice A Day
46%
Once A Day
4%
Bacterial infections
67%
Others
33%
Average
67%
Excellent
24%
Poor
10%
Nausea
33%
No Side Effect
33%
Dizziness
17%
Vomiting
17%
With food
57%
Empty stomach
29%
With or without food
14%
Average
62%
Expensive
24%
Not Expensive
14%
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Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.
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Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Address: 16th Floor, Godrej BKC, Plot – C, “G” Block, Bandra-Kurla Complex, Bandra (East), Mumbai – 400 051, India
Vendor Details
Country of origin: India
A licensed vendor partner from your nearest location will deliver Amoxyclav 375 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
A licensed vendor partner from your nearest location will deliver Amoxyclav 375 Tablet. Once the pharmacy accepts your order, the details of the pharmacy will be shared with you. Acceptance of your order is based on the validity of your doctor's ℞ and the availability of this medicine.
In case of any issues, contact us
Email ID: [email protected]Phone Number: 0124-4166666
Address: 5th Floor Tower - B of the Presidency Building, 46/4 Mehrauli Gurgaon Road, Sector 14, Gurugram, Haryana-122001, India
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- Thyroid Profile Total (T3, T4 & TSH)
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- PPBS (Postprandial Blood Sugar)
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