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For information purpose only
2Dege Oral Powder
Prescription Required
Product introduction
2Dege Oral Powder is the first Indian origin anti-Covid medication to receive emergency use approval for the acute treatment of moderate to severe COVID-19. It helps stop the growth of viruses in the body, thereby reducing the need for external oxygen and fastening recovery in hospitalized patients.
2Dege Oral Powder, also referred to as '2-DG', has been developed by Defence Research and Development Organisation (DRDO), in collaboration with Hyderabad based, Dr Reddy's Laboratories (DRL). Initial experiments with this medicine were conducted during the first wave of the pandemic, which demonstrated effectiveness against SARS-CoV-2 virus. Based on this, phase II and phase III clinical trials were conducted. The data from these showed that a significantly higher number of COVID-19 patients who were treated with 2-DG improved symptomatically and became free from supplemental oxygen dependence as compared to those being given standard care. Additionally, the medicine was found to be safe.
2Dege Oral Powder comes in powder form (sachet) that is to be taken orally by dissolving it in water. It may be taken twice daily for 5-7 days or as prescribed by the doctor based on the severity of the infection. As per the trials conducted, no side effects have been reported so far.
It is believed that this medicine will work on all the variants of Covid-19. 2Dege Oral Powder is recommended for use in hospital or institutional setup only. Patients with mild infections may not need the medicine as they may be able to recover at home if due protocols are followed. It is important to keep in mind that this medicine is to be given only in emergency cases. You should not take this medicine without the prescription of the doctor.
2Dege Oral Powder, also referred to as '2-DG', has been developed by Defence Research and Development Organisation (DRDO), in collaboration with Hyderabad based, Dr Reddy's Laboratories (DRL). Initial experiments with this medicine were conducted during the first wave of the pandemic, which demonstrated effectiveness against SARS-CoV-2 virus. Based on this, phase II and phase III clinical trials were conducted. The data from these showed that a significantly higher number of COVID-19 patients who were treated with 2-DG improved symptomatically and became free from supplemental oxygen dependence as compared to those being given standard care. Additionally, the medicine was found to be safe.
2Dege Oral Powder comes in powder form (sachet) that is to be taken orally by dissolving it in water. It may be taken twice daily for 5-7 days or as prescribed by the doctor based on the severity of the infection. As per the trials conducted, no side effects have been reported so far.
It is believed that this medicine will work on all the variants of Covid-19. 2Dege Oral Powder is recommended for use in hospital or institutional setup only. Patients with mild infections may not need the medicine as they may be able to recover at home if due protocols are followed. It is important to keep in mind that this medicine is to be given only in emergency cases. You should not take this medicine without the prescription of the doctor.
Uses of 2Dege Powder
- Acute treatment of moderate to severe Coronavirus disease (COVID-19)
Benefits of 2Dege Powder
In Acute treatment of moderate to severe Coronavirus disease (COVID-19)
2Dege Oral Powder being identical to glucose in structure can be produced easily and made readily available across the country. The medicine gets accumulated only in the virus-infected cells. Once entered, it prevents virus growth by stopping energy production that is needed for its further growth. 2Dege Oral Powder helps in faster recovery of hospitalized patients and reduces dependence on supplemental oxygen, thereby reducing the need for hospitalization. As per the clinical trials carried out in Covid patients, the medicine has shown a remarkable recovery rate with no side effects. Patients who were treated with 2Dege Oral Powder tested RT-PCR negative in a shorter span of time than those who were given standard treatment.
Side effects of 2Dege Powder
Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them
Common side effects of 2Dege
- No common side effects seen
How to use 2Dege Powder
Use this medicine in the dose and duration as advised by your doctor. Check the label for directions before use. 2Dege Oral Powder may be taken with or without food, but it is better to take it at a fixed time.
How 2Dege Powder works
2Dege Oral Powder is a medicine that resembles glucose structurally and is used to kill the virus causing Covid-19. The virus utilizes glucose to produce energy, and this energy is used by it to make copies of itself. Once given, 2Dege Oral Powder is readily absorbed by the ‘virus-infected cells’ as the virus takes it up just like glucose. On reaching the infected cells, the medicine stops energy production, inhibits further multiplication of the virus, and kills it. This helps in clearing the infection, even if it has spread to the lungs, and reduces the requirement of supplemental oxygen in moderate to severely infected Covid-19 patients.
Safety advice
Alcohol
CONSULT YOUR DOCTOR
It is not known whether it is safe to consume alcohol with 2Dege Oral Powder. Please consult your doctor.
Pregnancy
CONSULT YOUR DOCTOR
Information regarding the use of 2Dege Oral Powder during pregnancy is not available. Please consult your doctor.
Breast feeding
CONSULT YOUR DOCTOR
Information regarding the use of 2Dege Oral Powder during breastfeeding is not available. Please consult your doctor.
Driving
CONSULT YOUR DOCTOR
It is not known whether 2Dege Oral Powder alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Kidney
CONSULT YOUR DOCTOR
There is limited information available on the use of 2Dege Oral Powder in patients with kidney disease. Please consult your doctor.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of 2Dege Oral Powder in patients with liver disease. Please consult your doctor.
All substitutes
For informational purposes only. Consult a doctor before taking any medicines.
No substitutes found for this medicine
Quick tips
- 2Dege Oral Powder helps in faster recovery of hospitalized COVID-19 patients and reduces supplemental oxygen dependence.
- This medicine is to be used only in moderate to severe COVID-19 cases.
- The medicine comes in powder form in a sachet, which is taken orally by dissolving it in water twice a day. However, it should be consumed only on the advice of a doctor.
- A COVID-19 patient may have to take this drug for five to seven days to get completely cured.
- 2Dege Oral Powder currently is not meant to be given to children as safety and efficacy are not yet established.
Fact Box
Chemical Class
Fatty alcohol derivatives
Habit Forming
No
Therapeutic Class
ANTI NEOPLASTICS
Action Class
Antimetabolites
Patient concerns
FAQs
Q. What is 2-DG
2-DG is the short-form of DRDO's new anti-Covid oral medicine, 2-deoxy-D-glucose. It has been recently granted emergency use approval by the Drug Controller General of India (DCGI) as an adjunct therapy in moderate to severely infected cases of COVID-19. As per the clinical trials conducted so far, this medicine has reduced the supplemental oxygen dependence in even the hospitalized COVID-19 patients. Such patients showed faster recovery when treated with 2Dege Oral Powder.
Q. Why is 2Dege Oral Powder being considered unique?
2Dege Oral Powder is being considered unique as it has shown faster recovery in moderate to severe cases of Covid-19. This is because the medicine accumulates in the virus infected cells, and kills the virus. It can even kill the virus infection in the lungs. This helps the patients to recover faster.
Q. Where is 2Dege Oral Powder developed?
2Dege Oral Powder has been developed jointly by Institute of Nuclear Medicine and Allied Sciences, a lab of the Defence Research and Development Organisation (DRDO), in collaboration with Dr Reddy's Laboratories, Hyderabad.
Q. How is 2Dege Oral Powder taken?
2Dege Oral Powder can be taken easily by mouth (orally). It comes in a powdered form in a sachet and can be taken orally by dissolving it in water. However, it should be taken only if prescribed by a doctor.
Q. Is 2Dege Oral Powder safe?
Yes, trials have shown that 2Dege Oral Powder is safe if used in the dose and duration advised by your doctor. Take it exactly as directed and do not skip any dose. Follow your doctor's instructions carefully and let your doctor know if you have any other concerns.
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Disclaimer:
Tata 1mg's sole intention is to ensure that its consumers get information that is expert-reviewed, accurate and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified physician. The information provided here is for informational purposes only. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your doctor and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.References
- Ministry of Defence. DCGI approves anti-COVID drug developed by DRDO for emergency use. [Updated 08 May 2021]. [Accessed 18 May 2021] (online) Available from:
- Clinical Trials Registry - India. Phase II study to evaluate the Safety and Efficacy of 2-Deoxy-D-Glucose in COVID -19 patients. [Accessed 18 May 2021] (online) Available from:
- Madhya Pradesh Nurses Registration Council. DRDO Anti-Covid Drug (2DG Medicine) Approved, Efficacy, Price, Name. [Updated 18 May 2021]. [Accessed 18 May 2021] (online) Available from:
- Permission to Conduct Clinical Trial of New Drug or Investigational New Drug. [Accessed 19 May 2019] (online) Available from:
- Balkrishna A, Singh S, Dev S, et al. Glucose antimetabolite 2-Deoxy-D-Glucose and its derivative as promising candidates for tackling COVID-19: Insights derived from in silico docking and molecular simulations. Authorea. [Accessed 19 May 2019] (online) Available from:
- Verma A, Adhikary A, Woloschak G, et al. A combinatorial approach of a polypharmacological adjuvant 2-deoxy-D-glucose with low dose radiation therapy to quell the cytokine storm in COVID-19 management. Int J Radiat Biol. 2020;96(11):1323-1328. [Accessed 19 May 2019] (online) Available from:
- Defence Scientific Information & Documentation Centre. Newspapers Clippings: A Daily service to keep DRDO Fraternity abreast with DRDO Technologies, Defence Technologies, Defence Policies, International Relations and Science & Technology. [Accessed 19 May 2019] (online) Available from:
Marketer details
Name: Dr Reddy's Laboratories Ltd
Address: Dr. Reddy's Laboratories Ltd., Village Malpur, P.O.Bhud, Baddi, Dist. Solan, H.P.
Country of origin: India
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