Pyrazinamide is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.
Pyzina is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Pyzina bactericidal?
Pyzina is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does Pyzina work/treat tuberculosis?
Pyzina kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Pyzina is not known
Q. How does Pyzina cause hyperuricemia and gout?
Following oral intake of Pyzina, it gets converted in the body to pyrazinoic acid (active chemical form of Pyzina). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
Information last updated by Dr. Varun Gupta, MD Pharmacology on 27th Dec 2019. The medicine details are for information purpose only. Consult a doctor before taking any medicine.