Pyrazinamide is an antitubercular medicine. In the body, it gets converted to pyrazinoic acid. This pyrazinoic acid inhibits fatty acid synthase I (bacterial enzyme), which is essential for bacterial growth. Thus, it works as a bacteriocidal to prohibit their growth and treats tuberculosis.
Q. What is Actizid 1500mg Tablet and what is it used for?
Actizid 1500mg Tablet is an antibiotic. It is used in combination with other antibiotics in the treatment of tuberculosis
Q. Is Actizid 1500mg Tablet bactericidal?
Actizid 1500mg Tablet is both a bacteriostatic and a bactericidal antibiotic. It stops the growth of bacteria (bacteriostatic) in certain cases and kills (bactericidal) the tuberculosis causing bacteria in other cases
Q. How does Actizid 1500mg Tablet work/treat tuberculosis?
Actizid 1500mg Tablet kills or stops growth of bacteria that causes tuberculosis (Mycobacterium tuberculosis). The exact mechanism of action for Actizid 1500mg Tablet is not known
Q. How does Actizid 1500mg Tablet cause hyperuricemia and gout?
Following oral intake of Actizid 1500mg Tablet, it gets converted in the body to pyrazinoic acid (active chemical form of Actizid 1500mg Tablet). Pyrazinoic acid blocks the excretion of urates (salt form of uric acid) by the kidneys. This causes an increase in blood levels of uric acid (hyperuricemia). Excess uric acid accumulation between joints causes pain, swelling, redness and stiffness in joints (gout).
Information last updated by Dr. Varun Gupta, MD Pharmacology on 26th Aug 2022. The medicine details are for information purpose only. Consult a doctor before taking any medicine.