TNF Alpha (Tumour Necrosis Factor)

TNF-α (tumor necrosis factor alpha) is a protein made by the immune cells (white blood cells), especially macrophages and T-cells, when the body encounters infection, injury, or an attack by harmful substances. This chemical messenger signals other immune cells to respond and protect the body. This response is helpful during infections. The production of too much TNF-α can cause long-term inflammation in the body, as seen in conditions like rheumatoid arthritis (RA) or inflammatory bowel disease (IBD).

The TNF Alpha (Tumour Necrosis Factor) test helps find and track inflammation in autoimmune diseases like rheumatoid arthritis (RA), ankylosing spondylitis, inflammatory bowel disease (IBD), psoriasis, etc. Also, high levels of TNF-α can be seen in long-term infections or certain cancers. This test helps doctors diagnose or monitor autoimmune and inflammatory conditions and evaluate how well the anti-TNF-α treatment is working. It is also used for research purposes in long-term illnesses. 

No special preparation is required for the TNF Alpha (Tumour Necrosis Factor) test. The doctor should be informed about all medications, supplements, underlying illnesses, or immunomodulatory treatments, as these factors can affect the test results.

Laboratory test results may vary across laboratories. Do not self-medicate and always consult a doctor to understand the test results correctly. In some cases, repeat testing or additional confirmatory tests may be warranted.