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Total Leucocyte Count + Differential Leucocyte Count

Total Leucocyte Count + Differential Leucocyte Count

Also referred as
White blood cell count
Leukocytes
For men & women
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48 hours
Contains
6 tests
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The Total Leucocyte Count + Differential Leucocyte Count is a group of blood tests that checks for the total number of white blood cells (WBCs) in the blood along with a detailed breakdown of their different types. These tests help assess immune system function, diagnose infections, and monitor different blood disorders. 

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Understanding Total Leucocyte Count + Differential Leucocyte Count

Leukocytes, or white blood cells (WBCs), are part of the immune system and help protect the body from infections and diseases. There are five types of WBCs: basophils, eosinophils, lymphocytes, monocytes, and neutrophils, each playing a different role in fighting infections. The Total Leucocyte Count + Differential Leucocyte Count test measure two key parameters of WBCs: Total Leucocyte Count (TLC) and Differential Leucocyte Count (DLC). TLC shows the total number of white blood cells in the blood, while DLC breaks down the WBCs into different types and shows their percentage. These tests are important for evaluating the immune system and detecting conditions like infections, allergies, etc., or blood cancers.

The Total Leucocyte Count + Differential Leucocyte Count test identify infections, evaluate immune system health, and monitor treatment response to therapy such as chemotherapy, etc. Also, they help in the early detection of diseases such as leukemia, lymphoma, and allergic reactions. They can also be done as part of a complete blood count (CBC) for routine health screening to provide insights into your overall health. 

By determining the count of white blood cells present in the body and their relative proportions, TLC and DLC tests are helpful in determining how the immune system is responding to various conditions. A raised TLC (leucocytosis) may reflect an infection, inflammation, or blood cancer, while a low TLC (leukopenia) suggests a weakened immune response resulting from bone marrow disorders or viral infection. On the contrary, DLC may help pinpoint which of those white blood cells is involved, which is crucial in supporting doctors in diagnosing and differentiating diseases. 

No special preparation is needed for the Total Leucocyte Count + Differential Leucocyte Count test. Eat or drink normally as per the daily routine. However, it is important to inform the doctor about any medications, supplements, medical conditions, or vaccination history before the test, as these factors may potentially influence the test results.

Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. The test results will help the doctor determine the medical condition, make recommendations for lifestyle modifications such as diet and exercise, decide whether or not medication will be required to manage the condition, and formulate the overall treatment plan.

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What does Total Leucocyte Count + Differential Leucocyte Count measure?

Contains 6 tests

The Total Leucocyte Count + Differential Leucocyte Count is a group of two blood tests that help measure and analyze white blood cells (WBCs) in the body. The Total Leucocyte Count (TLC) counts the total number of WBCs in the blood, showing how healthy your system is. A high TLC usually means there's an infection or inflammation, while a low count may suggest bone marrow problems or a viral infection. The Differential Leucocyte Count (DLC) looks at the different types of WBCs, including neutrophils, lymphocytes, monocytes, eosinophils, and basophils. High DLC may indicate bacterial infection, allergies, etc., while low DLC could signal viral infections or immune system issues. 

Together, TLC and DLC tests give a complete picture of the immune system, helping to detect infections, track diseases, and guide treatment decisions. These tests are essential for managing immune-related issues.

There are five types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. A Differential Leukocyte Count test measures the percentage of each type of WBC in the blood. Leukocytes or WBCs are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

Know more about Differential Leukocyte Count

This further contains

  • Differential Neutrophil Count
  • Differential Lymphocyte Count
  • Differential Monocyte Count
  • Differential Eosinophil Count
  • Differential Basophil Count

The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

Know more about Total Leukocyte Count

FAQs related to Total Leucocyte Count + Differential Leucocyte Count

The Total Leucocyte Count + Differential Leucocyte Count is a set of two blood tests that measures and analyzes the numbers and types of white blood cells (WBCs) in the body. They help evaluate the immune system’s activity and detect infections or diseases.
Your doctor may suggest the Total Leucocyte Count + Differential Leucocyte Count tests for a wide range of health conditions, such as infections, inflammation, and blood cancer, or if you are on certain immunosuppressive medications or treatments.
Generally, there is no risk with these tests. However, some people may feel a slight sting while the needle is pricked and may experience some bleeding that is normal and usually not bothersome. Rarely, some people may also experience slight swelling or bruising at the site of the needle prick. Applying ice 3-4 times a day for about a week may help reduce swelling and bruising. If it does not get better, consult your doctor.
A phlebotomist (a trained professional to perform blood draws) will clean your skin using an antiseptic alcohol cotton swab or wipe and take blood samples from your vein using a needle. The blood sample will be stored safely and transported to the laboratory for analysis.
Generally, preparations such as fasting or dietary restrictions are not required for these tests. It is recommended to carefully follow your doctor’s guidance.
The frequency of getting tested for these tests depends on your health or existing underlying conditions. Individuals who suffer from chronic diseases, infections, or immune disorders may be required to undergo these tests from time to time. Consult your doctor for better guidance about the frequency that is right for you.
If your test results are abnormal, it is suggested to consult your doctor. They may recommend further tests based on your symptoms and medical history to determine the cause responsible for the abnormal findings.
The Total Leukocyte Count (TLC) measures the total number of white blood cells in the blood, while the Differential Leukocyte Count (DLC) breaks down the WBCs into their different types and shows their percentage.
A high Total Leukocyte Count usually indicates an active infection, inflammation, or an immune response, such as in conditions like bacterial infections, stress, or leukemia.
Leukocytosis is a condition where the leukocyte count is higher than its normal range. This may occur due to infections, inflammation, or certain conditions, such as rheumatoid arthritis, allergies, cancers like leukemia, myeloproliferative neoplasms, or conditions causing necrosis (tissue death) like severe burns, trauma, surgery, etc. Other factors like cigarette smoking, surgical removal of the spleen, allergy, very heavy physical exercise, pregnancy, or certain medicines like corticosteroids, epinephrine, heparin, lithium, etc. can also cause leukocytosis.
Leukopenia is a condition in which the leukocyte count is lower than its normal range. This may occur due to bone marrow damage or disorders, radiotherapy or chemotherapy, blood cancers, or certain infections like the human immunodeficiency virus (HIV).
Tata 1mg ensures accurate lab test results through certified laboratories that use advanced technology and adhere to stringent quality control measures. This commitment to high standards guarantees reliable results.
Content created by
Written by:
Dr. Lipika Khurana
PGDHHM, BDS
Reviewed by:
Dr. Swati Gupta (Anand)
MD Lab Medicine, MBBS
Want to know moreRead our editorial policy
Last Updated8th Oct 2025

Total Leucocyte Count + Differential Leucocyte Count test price for other cities

Price inKolkataRs. 279
Price inBangaloreRs. 279
Price inMumbaiRs. 229
Price inDehradunRs. 229
Price inNew DelhiRs. 269

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Contains 6 tests
Differential Leukocyte Count (5)
Differential Neutrophil Count
Differential Lymphocyte Count
Differential Monocyte Count
Differential Eosinophil Count
Differential Basophil Count
Total Leukocyte Count