Thalassemia Screening Profile near me in Noida

The Hemoglobin HPLC/Electrophoresis with CBC test identifies and measures different types of hemoglobin in the blood and assesses blood cell parameters through a CBC to help diagnose and keep track of certain blood disorders. These types of hemoglobin include: adult type (HbA2), fetal type (HbF), hemoglobin S (HbS), hemoglobin C (HbC), and hemoglobin E (HbE), among others.

The CBC measures parameters such as:

• Hemoglobin (Hb): Measures the amount of hemoglobin in the blood.
• Hematocrit (HCT): Measures the proportion of blood made up of red blood cells.
• Red blood cell (RBC) count: Measures the number of red blood cells in the blood.
• Red blood cell indices: Include MCV, MCH, MCHC, and RDW, which provide information about the size, hemoglobin content, and variation in the size of red blood cells.
• White blood cell (WBC) count and platelet count: Provide information about other blood cell types.

Normal hemoglobin types:

• Hemoglobin A (HbA): The main type of hemoglobin in healthy adults.
• Hemoglobin F (HbF): Found in unborn babies and newborns. It is slowly replaced by HbA after birth.

If the levels of HbA or HbF are not normal, it may indicate certain types of anemia. The interpretation depends on the overall hemoglobin pattern and CBC findings.

Abnormal hemoglobin types:

• Hemoglobin S (HbS): Found in people with sickle cell anemia. It causes red blood cells to become stiff and sickle-shaped, leading to pain and other health problems.
• Hemoglobin C (HbC): Linked to a condition called hemolytic anemia, where red blood cells break down faster than normal.
• Hemoglobin E (HbE): Common in people from Southeast Asia. It may cause mild anemia or sometimes no symptoms at all in the heterozygous state.
• Hemoglobin D (HbD): Causes mild hemolytic anemia and mild to moderate spleen enlargement. The Hb D Punjab variant is most commonly seen in people from Gujarat and among Sikhs of Punjab.

The HPLC or electrophoresis pattern, together with CBC findings and clinical history, helps the doctor assess whether further testing is required.

The Peripheral Smear Examination test is performed to check the characteristics of blood cells including:

1. Red blood cells (RBCs)
2. White blood cells (WBCs)
3. Platelets

By placing the blood sample on a specifically treated slide, these blood components are analyzed under a microscope for their shape, size, and number. Any irregularity in these cells indicates blood disorders or abnormality, the presence of parasites in the blood, etc. This test is also a beneficial tool in monitoring a blood disease or deciding whether a certain medication or therapy is working effectively or not.

The Serum Iron Studies Comprehensive package measures the level of iron in the body. It comprises a series of blood tests, including serum iron test that helps to evaluate iron level, total iron binding capacity (TIBC) test that helps to assess the ability of the body to transport iron in the blood, unsaturated iron binding capacity (UIBC) test that reflects binding of iron with transferrin, which is the main protein that binds with iron, transferrin saturation test that checks how many places on the transferrin that can hold iron are doing so, and ferritin test that detects ferritin protein in the blood and helps determine how much iron is stored in your body.