Tata Projects Parental Medical Check-up (Female) near me in Jaipur

The Thyroxine - Free (FT4) test measures the free form of thyroxine (T4) hormone made by the thyroid gland. T4 hormone exists in the blood in two forms: bound (attached to proteins) and free (not attached to proteins). Most of the T4 hormone circulating in the blood is bound to proteins and only a small part is free. A delicate balance of bound and free T4 should be maintained to ensure the proper functioning of the body.

The TSH (Thyroid Stimulating Hormone) Ultrasensitive test measures the levels of TSH hormone in the blood. TSH is produced by the pituitary gland located at the base of the brain. Its function is to stimulate and regulate the functioning of the thyroid gland. It signals the thyroid gland to increase or decrease the production of thyroid hormones T3 and T4 when their levels are low or high, respectively. Therefore, when the levels of T3 & T4 decrease, the pituitary gland is stimulated to release TSH. This high TSH level, in turn, stimulates the thyroid gland to release more thyroid hormones (T3 & T4). Vice versa happens when the levels of thyroid hormones increase.

What Do the Results Mean?

Pathological Factors

Physiological Factors

 🧒Age: TSH may slightly increase with age.

🫄 Pregnancy: TSH levels may drop in early pregnancy because of hormonal changes.

🧑‍🦳 Gender: Women generally have higher TSH levels than men and are more prone to thyroid imbalances, especially during pregnancy, after childbirth, or around menopause.

⚖️ Body Weight & Metabolism: Weight gain or loss can slightly affect TSH levels.

Lifestyle Factors

🥗 Diet: Too little iodine can increase TSH, while too much may lower it.

😟 Stress: Long-term stress can disturb thyroid hormone balance.

💊 Medications: Some medicines, like steroids or lithium, can change TSH levels.

🛌 Sleep Patterns: Poor sleep can affect thyroid hormone control.

🚬 Smoking & Alcohol: Smoking may lower TSH, and too much alcohol can harm thyroid function.

🏃 Physical Activity: Regular exercise supports thyroid health, but extreme workouts can cause temporary TSH changes.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.

What Do Normal TSH (Thyroid Stimulating Hormone) Ultrasensitive Levels Mean?

Normal TSH levels indicate that your thyroid is functioning well, producing the right amount of thyroid hormones (T3 and T4) to regulate metabolism, energy, and overall body functions. Balanced TSH suggests your body is maintaining proper hormonal balance, supporting healthy weight, energy levels, mood, and cardiovascular health.

What Do High Levels of TSH (Thyroid Stimulating Hormone) Ultrasensitive Indicate?

High TSH levels usually mean the thyroid is underactive (hypothyroidism). The pituitary gland releases extra TSH to make the thyroid produce more hormones.

Common causes include:

• Autoimmune thyroid problems like Hashimoto’s thyroiditis
• Pituitary gland disorders
• Recovery after illness or thyroid surgery
• Some medicines or a lack of nutrients

What to Do if Your TSH (Thyroid Stimulating Hormone) Is Higher Than Normal?

If your TSH level is high, talk to your doctor. They may: 

• Recheck with more thyroid tests (T3, T4, or antibodies)
• Review your medicines, diet, and health history
• Recommend thyroid hormone treatment if required
• Track symptoms like tiredness, weight gain, feeling cold, or hair loss

Timely management can help control thyroid imbalances effectively.

What Do Low Levels of TSH (Thyroid Stimulating Hormone) Ultrasensitive Indicate?

Low TSH levels usually mean your thyroid is overactive (hyperthyroidism). This happens when the thyroid releases excess thyroid hormones, so the pituitary gland reduces TSH production.

Possible causes include:

• Graves’ disease (autoimmune thyroid disorder)
• Thyroid nodules that produce extra hormones
• Thyroid inflammation (thyroiditis)
• Taking too much thyroid medicine

If your TSH is low, your doctor may suggest more tests like T3, T4, thyroid antibody tests, or an ultrasound to find the cause and decide the right treatment.

Can TSH Results Be Inaccurate?

Yes. Certain factors such as pregnancy, recent illness, medications, or underlying pituitary or thyroid disorders can affect TSH levels and lead to inaccurate results. If your results do not match your symptoms or overall health, your doctor may suggest repeating the test or additional testing. 

What Factors Can Affect TSH (Thyroid Stimulating Hormone) Ultrasensitive Results?

The TSH (Thyroid Stimulating Hormone) Ultrasensitive test is reliable, but a few factors can affect its accuracy, such as:

• Recent thyroid surgery or radioactive iodine treatment
• Taking biotin supplements
• Severe illness or hospitalization
• Certain medicines (like amiodarone or lithium)
• Pregnancy

What Follow-Up Tests May Be Required?

Based on your TSH results, your doctor may suggest more tests to better understand your thyroid health. These tests may include:

Table: Tests Commonly Ordered Alongside TSH

How Does TSH Test Differ from Other Thyroid Tests?

It is important to understand how the TSH test differs from other common thyroid tests:

TSH (Thyroid-Stimulating Hormone): Measures how much signal the pituitary gland is sending to the thyroid to make hormones.

Total T4: Measures the overall amount of thyroxine (T4) in the blood, including both bound and unbound forms, to understand thyroid hormone production.

Free T4 (FT4): Checks the active form of T4 that is available for use by the body. It helps assess how well the thyroid is functioning.

Total T3: Measures the total amount of triiodothyronine (T3), the active hormone derived from T4, often helpful in detecting hyperthyroidism.

Free T3 (FT3): Evaluates the unbound, active T3 level to understand how efficiently T4 is being converted to T3.

Thyroid Antibody Tests (TPOAb, TgAb): Identify autoimmune thyroid conditions like Hashimoto’s thyroiditis or Graves’ disease.

The Triiodothyronine - Free (FT3) test measures the levels of free triiodothyronine (T3), a hormone produced by the thyroid gland. T3 hormone plays a vital role in regulating the body's metabolism, energy levels, and growth & development. It exists in the blood in two forms: free T3 and bound T3. Only a small portion of T3 is free (not bound to proteins) and can be utilized by the body’s tissues. In contrast, more than 99% of T3 is bound to proteins, such as albumin and thyroid-binding globulin (TBG), preventing it from entering the tissues. The body balances bound and free T3 to ensure proper functioning. 

The Red Blood Cell Count test measures the total number of red blood cells in your blood. RBCs are the most abundant cells in the blood with an average lifespan of 120 days. These cells are produced in the bone marrow and destroyed in the spleen or liver. Their primary function is to help carry oxygen from the lungs to different body parts. The normal range of RBC count can vary depending on age, gender, and the equipment and methods used for testing.

The Hb (Hemoglobin) test measures the concentration of hemoglobin in your blood. Hemoglobin binds oxygen molecules and carries them to body tissues while removing carbon dioxide. Low hemoglobin suggests reduced oxygen-carrying capacity. It can be due to anemia, bleeding, nutritional deficiencies (iron, vitamin B12, folate), or chronic disease. High hemoglobin may occur in dehydration, living at high altitudes, smoking, or diseases like polycythemia vera.

What Do the Results Mean?

Pathological Factors 

The Platelet Count test measures the average number of platelets in the blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days. 

Platelets help stop the bleeding, whenever there is an injury or trauma to a tissue or blood vessel, by adhering and accumulating at the injury site and releasing chemical compounds that stimulate the gathering of more platelets. A loose platelet plug is formed at the site of injury and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps, including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this step, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding. 

The Total Leukocyte Count test measures the numbers of all types of leukocytes, namely neutrophil, lymphocyte, monocyte, eosinophil, and basophil, in your blood. Leukocytes or WBCs are an essential part of our immune system. These cells are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

The Hematocrit test measures the proportion of red blood cells (RBCs) in your blood as a percentage of the total blood volume. It is a crucial part of a complete blood count (CBC) and helps in assessing your blood health. RBCs are responsible for carrying oxygen from the lungs to different parts of the body. The hematocrit test provides valuable information about your blood's oxygen-carrying capacity.

Higher-than-normal amounts of RBCs produced by the bone marrow can cause the hematocrit to increase, leading to increased blood density and slow blood flow. On the other hand, lower-than-normal hematocrit can be caused by low production of RBCs, reduced lifespan of RBCs in circulation, or excessive bleeding, leading to a reduced amount of oxygen being transported by RBCs. Monitoring your hematocrit levels is essential for diagnosing and managing various blood-related disorders.

The Mean Corpuscular Volume test measures the average size of your red blood cells, which carry oxygen through your body. This test tells whether your RBCs are of average size and volume or whether they are bigger or smaller.

An MCH test measures the average amount of hemoglobin in a single red blood cell (RBC). Hemoglobin is an iron-containing protein in RBCs, and its major function is to transport oxygen from the lungs to all body parts. This test provides information about how much oxygen is being delivered to the body by a certain number of RBCs.

An MCHC test measures the average amount of hemoglobin in a given volume of RBCs. MCHC is calculated by dividing the amount of hemoglobin by hematocrit (volume of blood made up of RBCs) and then multiplying it by 100. 

An MPV test measures the average size of the platelets in your blood. Platelets are disk-shaped tiny cells originating from large cells known as megakaryocytes, which are found in the bone marrow. After the platelets are formed, they are released into the blood circulation. Their average life span is 7-10 days. 

Platelets help stop bleeding whenever there is an injury or trauma to a tissue or blood vessel by adhering and accumulating at the injury site, and by releasing chemical compounds that stimulate the gathering of more platelets. After these steps, a loose platelet plug is formed at the site of injury, and this process is known as primary hemostasis. These activated platelets support the coagulation pathway that involves a series of steps including the sequential activation of clotting factors; this process is known as secondary hemostasis. After this, there is a formation of fibrin strands that form a mesh incorporated into and around the platelet plug. This mesh strengthens and stabilizes the blood clot so that it remains in place until the injury heals. After healing, other factors come into play and break the clot down so that it gets removed. In case the platelets are not sufficient in number or are not functioning properly, a stable clot might not form. These unstable clots can result in an increased risk of excessive bleeding. 

The RDW CV test which is part of red cell indices, helps identify characteristics of red blood cells. RDW (red cell distribution width) measures the variations in the sizes of red blood cells, indicating how much they differ from each other in a blood sample. RDW is expressed as RDW-CV, a coefficient of variation. A higher RDW may suggest more variation in red cell sizes, while a lower RDW indicates more uniform red cell sizes.

The PDW test reflects variability in platelet size, and is considered a marker of platelet function and activation (clot formation in case of an injury). This marker can give you additional information about your platelets and the cause of a high or low platelet count. Larger platelets are usually younger platelets that have been recently released from the bone marrow, while smaller platelets may be older and have been in circulation for a few days. Higher PDW values reflect a larger range of platelet size, which may result from increased activation, destruction and consumption of platelets.

The Absolute Leucocyte Count test measures the total number of white blood cells (leucocytes) in the given volume of blood. It examines different types of white blood cells such as neutrophils, lymphocytes, monocytes, basophils and eosinophils. These cells tell about the status of the immune system and its ability to fight off infections and other conditions like inflammation, allergies, bone marrow disorders etc.

There are five types of WBCs: neutrophils, lymphocytes, monocytes, eosinophils, and basophils. A Differential Leukocyte Count test measures the percentage of each type of WBC in the blood. Leukocytes or WBCs are produced in the bone marrow and defend the body against infections and diseases. Each type of WBC plays a unique role to protect against infections and is present in different numbers.

The Cholesterol - LDL test measures the concentration of low-density lipoprotein (LDL) cholesterol in the blood. LDL cholesterol plays an important role in your body. It carries cholesterol from your liver to other parts of the body where it's needed for things like building cell walls and making hormones. However, it is often referred to as "bad" cholesterol because when present in excess in your blood, it can stick to your blood vessel walls leading to the formation of plaque, making them narrow and less flexible. When this happens, it's harder for the blood to flow, which can lead to heart problems, like heart attacks and strokes. By measuring LDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and can recommend appropriate preventive or treatment strategies.

The Triglycerides test measures the amount of triglycerides in the blood and helps evaluate your risk of developing cardiovascular diseases. Triglycerides are a type of fat (lipid) that your body uses as a source of energy. When you consume more calories than your body needs, the excess calories are converted into triglycerides and stored in fat cells for later use. High triglyceride levels can contribute to the hardening and narrowing of arteries, increasing the risk of heart attack, stroke, and other related conditions. 

The Cholesterol - Total test measures the total amount of cholesterol (fats) in your blood. Cholesterol is mainly synthesized in the liver and partially in the intestines. It acts as a building block for cell membranes, is a precursor to vital hormones, and helps produce bile acids that help digest fats. Cholesterol is transported through the blood as lipoproteins: low-density lipoprotein (LDL) and high-density lipoprotein (HDL). An optimal amount of these proteins is necessary for proper body functioning.

The Cholesterol - HDL test measures the concentration of high-density lipoprotein (HDL) cholesterol in the blood. HDL cholesterol plays a crucial role in maintaining cardiovascular health, as it helps transport excess low-density lipoprotein (LDL) cholesterol from the bloodstream back to the liver for excretion. This process prevents plaque buildup on the blood vessel walls, which can cause them to become narrow and less flexible. Higher HDL cholesterol levels are generally associated with a lower risk of heart problems, such as heart attacks and strokes. By measuring HDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies, including lifestyle modifications and medications.

The Very Low Density Lipoprotein test measures the concentration of very-low-density lipoprotein (VLDL) cholesterol in the blood. VLDL cholesterol plays a vital role in the body's metabolic processes. It is produced by the liver and is used to transport triglycerides, a type of fat, from the liver to various tissues throughout the body, where they are either utilized for energy or stored for later use. Though VLDL cholesterol is essential for the body's normal functioning, it is harmful if present in excess amounts. By measuring VLDL cholesterol levels, your doctor can assess your risk of developing cardiovascular diseases and recommend appropriate preventive or treatment strategies.

The Total Cholesterol/HDL Cholesterol Ratio test measures the ratio of total cholesterol and high-density lipoprotein (HDL)/good cholesterol in your blood which is a significant indicator of cardiovascular health. This ratio is calculated by dividing the total cholesterol by the HDL number. A high ratio indicates a higher amount of 'bad' cholesterol relative to 'good' cholesterol, implying a higher risk of developing heart disease. Conversely, a lower ratio implies a higher amount of 'good' cholesterol relative to 'bad' cholesterol, indicating a lower risk.

An LDL/HDL Ratio test measures the ratio of low-density lipoproteins (LDL) to high-density lipoproteins (HDL) in your blood. These two types of lipoproteins carry cholesterol throughout the body. LDL, often referred to as the 'bad' cholesterol, carries cholesterol to the cells that need it. However, if there is too much LDL cholesterol in the blood, it can combine with other substances and form plaque in the arteries, leading to cardiovascular diseases. On the other hand, HDL, often referred to as the 'good' cholesterol, helps remove other forms of cholesterol, including LDL, from the bloodstream. It transports cholesterol back to the liver, where it is broken down and eliminated from the body, thus reducing the risk of cholesterol buildup and heart disease. The LDL/HDL ratio is a significant indicator of cardiovascular health. A high ratio indicates a higher amount of 'bad' cholesterol relative to 'good' cholesterol, implying a higher risk of developing heart disease. Conversely, a lower ratio implies a higher amount of 'good' cholesterol relative to 'bad' cholesterol, indicating a lower risk.

The Non HDL Cholesterol test looks for the “bad” cholesterol particles that are likely to contribute to heart problems. These bad particles include LDL (low-density lipoprotein) cholesterol, VLDL (very-low-density lipoprotein) cholesterol, and remnants of other cholesterol-carrying molecules. Cholesterol is a waxy substance that circulates in your bloodstream and is essential for various bodily functions. However, too much of “bad” types of cholesterol can build up in your arteries and increase the risk of heart conditions. LDL and VLDL cholesterol particles are often referred to as the "bad" cholesterol because they can stick to the walls of your arteries and form plaque, narrowing the arteries and restricting blood flow to your heart. By measuring non-HDL cholesterol, your doctor can assess your risk of heart disease and determine if any interventions or lifestyle changes are needed to protect your heart.

An Alkaline Phosphatase (ALP) test measures the quantity of ALP enzyme present throughout the body. The main sources of this enzyme are the liver and bones. It exists in different forms depending on where it originates, such as liver ALP, bone ALP, and intestinal ALP. In the liver, it is found on the edges of the cells that join together to form bile ducts. 

ALP levels can be increased during pregnancy as it is found in the placenta of pregnant women. It is also higher in children because their bones are in the growth phase. ALP is often high during growth spurts (a short period when an individual experiences quick physical growth in height and body weight).

An SGOT (Aspartate Aminotransferase) test measures the levels of serum glutamic-oxaloacetic transaminase (SGOT), also known as aspartate aminotransferase (AST), an enzyme produced by the liver. SGOT is present in most body cells, most abundantly in the liver and heart. The primary function of this enzyme is to convert food into glycogen (a form of glucose), which is stored in the cells, primarily the liver. The body uses this glycogen to generate energy for various body functions.

The Bilirubin (Total, Direct and Indirect) test measures the level of three forms of bilirubin such as total bilirubin, direct (conjugated bilirubin), and indirect (unconjugated) bilirubin in the blood. Total bilirubin represents the sum of direct and indirect bilirubin. Direct bilirubin is the water-soluble form of bilirubin that has been processed by the liver via a conjugation process with glucuronic acid and is ready to be excreted into the bile ducts and ultimately into the intestines. Indirect bilirubin is the water-insoluble form of bilirubin that has not yet been processed by the liver and is bound to albumin in the blood. It is formed in the spleen and liver during the breakdown of hemoglobin from old or damaged red blood cells and cannot be excreted directly by the liver. Instead, it is transported to the liver, where it undergoes conjugation to become direct bilirubin. 

Getting tested with the Bilirubin (Total, Direct and Indirect) test provides valuable information into various aspects of liver function, bile duct health, and the body’s ability to break down and eliminate bilirubin.

The Protein Total, Serum test measures the amount of proteins in the body. Proteins are known as the building blocks of all cells and tissues. They play a crucial role in the growth and development of most of your organs and in making enzymes and hormones. There are two types of proteins found in the body, namely albumin and globulin. About 60% of the total protein is made up of albumin, which is produced by the liver. It helps to carry small molecules such as hormones, minerals, and medicines throughout the body. It also serves as a source of amino acids for tissue metabolism. On the other hand, globulin is a group of proteins that are made by the liver and the immune system. They play an important role in liver functioning, blood clotting, and fighting off infections.

Gamma-Glutamyl Transferase (GGT) is an enzyme found in various organs, with the highest concentration in the liver. Usually, this enzyme is present in low levels in the blood. However, when there is liver damage or disease, GGT is released into the bloodstream, causing an increase in GGT levels. In addition to the liver, GGT can also be elevated in conditions affecting the bile ducts or the pancreas. It is usually, the first liver enzyme to rise in the blood when there is any damage or obstruction in the bile duct, making it one of the most sensitive liver enzyme tests for detecting bile duct problems.

An SGPT (Alanine Transaminase) test measures the amount of alanine transaminase (ALT) or SGPT enzyme in your blood. ALT is most abundantly found in the liver but is also present in smaller amounts in other organs like the kidneys, heart, and muscles. Its primary function is to convert food into energy. It also speeds up chemical reactions in the body. These chemical reactions include the production of bile and substances that help your blood clot, break down food and toxins, and fight off an infection.

Elevated levels of ALT in the blood may indicate liver damage or injury. When the liver cells are damaged, they release ALT into the bloodstream, causing an increase in ALT levels. Therefore, the SGPT/ALT test is primarily used to assess the liver's health and to detect liver-related problems such as hepatitis, fatty liver disease, cirrhosis, or other liver disorders.

The Blood Urea test measures the level of urea in the blood. Urea is a byproduct of protein metabolism. Proteins you consume in your diet are digested and converted into amino acids, which are then utilized by the body. This metabolic process produces a toxic byproduct known as ammonia. Ammonia is then rapidly converted into urea by your liver. Urea is comparatively less toxic than ammonia and is transported to the kidneys via the blood. The kidneys then filter it out through the urine. This process continues and the body keeps producing and eliminating urea, maintaining its low and steady levels in the blood.

The Sodium test measures the amount of sodium in your body. Sodium is present in all body fluids and is found in the highest concentration in the extracellular fluid. The body absorbs the required amount of sodium through dietary salts, and the kidneys eliminate the remaining sodium. The body keeps your blood sodium within a regular and steady range by following three mechanisms:

• By producing hormones that control the elimination of sodium through urine, such as natriuretic peptides and aldosterone.

• By producing hormones that prevent water loss, such as antidiuretic hormone (ADH).

• By controlling thirst (an increase in blood sodium level can make you thirsty and cause you to drink water, returning your sodium to normal).

These mechanisms regulate the amount of water and sodium in the body and control blood pressure by keeping the amount of water in check. When the sodium level in the blood changes, the water content in your body changes. These changes can be associated with dehydration, edema, and changes in blood pressure.

The Chloride test measures the amount of chloride in your body. Chloride is present in all body fluids and is found in the highest concentration in the blood and extracellular fluid (fluid present outside the cells). The body gets most of the chloride through dietary salt (sodium chloride or NaCl) and a small amount through other food items. The required amount of chloride is absorbed in the body and the excess amount is excreted by the kidneys through urine. When the chloride is combined with sodium it is mostly found in nature as salt. Chloride generally increases or decreases in direct relationship to sodium but may also change without any changes in sodium levels when there are problems with the body's pH. Usually, the normal blood chloride level remains steady with a slight fall after meals (because the stomach produces hydrochloric acid using chloride from the blood after we eat food).

The Potassium test measures the levels of potassium in your body. Potassium is one of the key electrolytes that helps in the functioning of the kidneys, heart, nerves, and muscles. It also balances the effect of sodium and helps keep your blood pressure normal. The body absorbs the required amount of potassium from the dietary sources and eliminates the remaining quantity through urine. Potassium level is typically maintained by the hormone aldosterone. Aldosterone acts on the nephrons present in the kidneys and activates the sodium-potassium pump that helps the body reabsorb sodium and excrete potassium. This aids in maintaining a regular and steady potassium level in the blood.

The Serum Creatinine test measures the creatinine level, a byproduct produced by the wear and tear of muscles during energy production. Since kidneys help filter creatinine, this test helps determine how well your kidneys work. Usually, high levels of creatinine in the blood signal diminished kidney function. At the same time, low levels may indicate decreased muscle mass.

What Do the Results Mean?

Pathological Factors 

Physiological Factors

🧒 Age: Creatinine levels may decrease with age (due to reduction in muscle mass).

🫄 Pregnancy: Slightly lower levels can be seen due to physiological changes in kidney function during pregnancy.

Lifestyle Factors

🥗 Diet: High protein intake may transiently increase creatinine.

🏋️ Exercise: Intense physical activity can temporarily elevate creatinine levels.

💊 Medications: Some medicines, such as NSAIDs, antibiotics, or certain blood pressure medications, may influence kidney function and creatinine levels.

Disclaimer: This information is for educational purposes only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider for personalized guidance.

What Do Normal Serum Creatinine Levels Mean?

Normal serum creatinine levels indicate that the kidneys are functioning properly and effectively filtering waste products from the blood.

What Do High Levels of Serum Creatinine Indicate?

High serum creatinine may indicate impaired kidney function, dehydration, urinary tract obstruction, or other conditions affecting renal health.

What to Do if Your Serum Creatinine Is Higher Than Normal?

If your creatinine level is higher than normal, consult your doctor for proper guidance. They may recommend additional tests, lifestyle adjustments, medication review, or referral to a nephrologist.

What Do Low Levels of Serum Creatinine Indicate?

Low levels are uncommon but may indicate low muscle mass, malnutrition, or liver disease. Always discuss results with your healthcare provider.

Can Serum Creatinine Results Be Inaccurate?

Yes, serum creatinine results can sometimes be inaccurate. Factors such as severe muscle loss, certain medications or supplements, and variations or errors in laboratory test methodologies can affect the accuracy of the results.

What Factors Can Affect Serum Creatinine Results?

Though a reliable test, several factors can influence accuracy:

• Muscle mass, age, sex
• Diet, hydration status
• Medications affecting kidney function
• Severe illness or trauma
• Hyperbilirubinemia

What Follow-Up Tests May Be Required?

Depending on your serum creatinine results, your doctor may recommend additional tests to get a clearer picture of kidney health. These can include urine tests, such as urine protein or microalbumin or cystatin C, to detect early kidney damage; an eGFR calculation to estimate kidney filtration efficiency; kidney imaging, like an ultrasound, to check for structural abnormalities; and electrolyte or kidney function panels to assess overall kidney performance and detect any imbalances. Fasting is not recommended for this test, you can eat and drink as per your daily routine.

Table: Tests Commonly Ordered Alongside the Serum Creatinine Test

The Uric Acid, Serum test measures the amount of uric acid in your blood. Uric acid is a waste product formed when the body breaks down purines. Purines are the natural substances found in your body’s cells (DNA) and in certain foods like red meat or seafood. Under normal conditions, uric acid dissolves in the blood, passes through the kidneys, and is excreted in the urine. When this process doesn’t work properly, due to either increased production or reduced elimination, the uric acid can build up in the blood. This may indicate underlying health issues such as kidney dysfunction, gout, or the presence of kidney stones. In some cases, the exact reason for high uric acid levels is unclear. On the other hand, low uric acid levels are rarely a cause for concern. This test helps doctors understand if uric acid levels are within a healthy range and whether further evaluation or treatment is needed.

What Do the Results Mean?

Pathological Factors 

The Blood Urea Nitrogen test measures the levels of urea nitrogen in the blood. Blood urea is a waste product that is formed in the liver when you eat food and the protein is metabolized into amino acids. This process leads to the production of ammonia that is further converted into urea. Both ammonia and urea are nitrogenous compounds. Your liver releases urea into the blood which is then carried out to the kidneys. In the kidneys, urea is filtered from the blood and flushed out of the body via urine. This is a continuous process, so a small amount of urea nitrogen always remains in the blood.

In the case of a kidney or liver disease, there is a change in the amount of urea present in the blood. If your liver produces urea in an increased amount or if there is any problem in kidney functioning, there might be difficulty in filtering out the waste products from the blood, which can result in increased urea levels in the blood.

The BUN/Creatinine Ratio test helps compare the levels of blood urea nitrogen to that of creatinine in your body. Urea is a waste product that is formed in the liver when you eat protein, which is then metabolized into amino acids. This process leads to the production of ammonia that is further converted into urea. Later, the urea is passed out of your body through the urine. On the other hand, creatinine is a byproduct produced by muscles during energy production. Therefore, the more muscle you have, the more creatinine your body produces. The kidneys remove both the urea and creatinine via urine, and this test determines how well your kidneys are functioning.

The Total Iron Binding Capacity test measures the ability of your blood to bind and transport iron, and therefore reflects your body's iron stores. TIBC correlates with the amount of transferrin, a protein, in your blood, that helps bind iron and facilitates its transportation in the blood. Usually, about one-third of the transferrin measured is being used to transport iron, and this is called transferrin saturation.

An Iron, Serum test determines iron levels in the blood and can help diagnose conditions like anemia, or iron overload in the body. People usually suffer from low iron levels in the blood if they prefer a diet that has low iron content, or if their body has trouble absorbing the iron from the foods or supplements they intake. Low iron levels can also occur due to intense blood loss or even during pregnancy. Similarly, an excess amount of iron in the blood can occur due to over-intake of iron supplements, blood transfusions, or if you are suffering from a condition called hemochromatosis (a rare genetic disorder that causes too much iron to build up in the body or cause problems in the body to remove excess iron). 

Therefore, doctors often suggest an Iron, Serum to help check the status of your iron level, get valuable information about your nutritional well-being, detect potential health issues (if any), and take timely preventive measures.

The Serum Ferritin test measures the concentration of ferritin in the blood. Ferritin is a protein found in cells, particularly in the liver, spleen, and bone marrow, that stores iron in a soluble or nontoxic form. When the body needs iron for essential functions like producing red blood cells and carrying oxygen, it releases iron from ferritin into the blood.

The Serum Ferritin test provides valuable information about the body's iron storage levels. Low ferritin levels may indicate iron deficiency, a condition where the body lacks enough iron to function properly. In contrast, elevated ferritin levels can indicate iron overload, a condition known as hemochromatosis. Iron overload can lead to organ damage if not adequately managed, making early detection crucial.

The Serum Ferritin test is a critical tool for assessing iron status, diagnosing iron deficiency anemia, monitoring treatment progress, detecting other iron-related disorders, and maintaining overall health.

The Transferrin Saturation test determines an individual’s iron status by using the ratio of serum iron concentration and total iron binding capacity (TIBC) as a percentage. The test tells us how much iron in the blood is bound to transferrin, the main protein in the blood that binds to iron and transports it throughout the body. Under normal conditions, transferrin is one-third saturated with iron, so about two-thirds of its capacity is held in reserve. This test is often employed alongside others to evaluate iron levels and diagnose conditions like iron deficiency anemia if transferrin saturation is low or hemochromatosis (an iron overload disorder) if transferrin saturation is higher than normal.

An Unsaturated Iron Binding Capacity test determines the reserve capacity of transferrin, i.e., the portion not yet saturated with iron. The iron-binding capacity of our body can be segregated into two parts – Total Iron Binding Capacity (TIBC) and Unsaturated Iron Binding Capacity (UIBC). UIBC refers to the capacity of transferrin, a protein that transports iron, to bind with additional iron. In easy terms, it represents the available "slots" on transferrin to carry iron molecules. Unlike iron saturation, which assesses the occupied slots, UIBC measures the unoccupied ones.