Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS]

Chronic myeloproliferative neoplasms (MPNs) are blood disorders in which the bone marrow produces too many red blood cells, white blood cells, or platelets.

The Myeloproliferative Neoplasm (MPN) Reflex Panel [NGS] is used to evaluate genetic changes in blood cells that are characteristic of myeloproliferative neoplasms (MPNs). These include conditions such as polycythemia vera (PV), essential thrombocythemia (ET), primary myelofibrosis (PMF), and chronic myeloid leukemia (CML). This panel combines multiple molecular assays to detect mutations in genes associated with MPNs, including JAK2, MPL, and CALR. 

This panel works in a stepwise or “reflex” manner. It first checks for the common JAK2 V617F mutation. If this result is negative, the test automatically analyzes other regions of the JAK2 gene, followed by the MPL and CALR genes if needed. This step-by-step process helps identify mutations that cause MPNs, ensuring accurate and efficient diagnosis. 

Doctors may recommend this test if you have abnormal blood counts, symptoms such as fatigue, weakness, night sweats, or an enlarged spleen, or a family history of MPNs. The test helps differentiate between MPN subtypes, guide treatment decisions, monitor disease progression, and assess the risk of complications.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.

Note: Genetic counseling can be provided. If interested, please send the request to this email id:[email protected]