MPN Panel 8 near me in Coimbatore

The Erythropoietin (EPO)+Jak 2 Exon 12-15 test measures serum erythropoietin (EPO) levels to determine whether red blood cell production is driven by hormones or occurs independently. It also detects mutations in the JAK2 gene (exons 12 to 15), which can cause abnormal activation of the JAK-STAT pathway and lead to myeloproliferative disorders. A low EPO level with a positive JAK2 mutation supports the diagnosis of polycythemia vera, whereas a normal or elevated EPO level with no JAK2 mutation points to a secondary cause, such as chronic hypoxia or kidney disease. By combining hormonal and genetic insights, this test helps accurately differentiate the origin of disease and enables clinicians to develop a personalized treatment plan.