MPN Panel 1

Chronic myeloproliferative neoplasms (MPNs) are blood disorders in which the bone marrow produces too many red blood cells, white blood cells, or platelets. 

The MPN Panel 1 is a focused genetic panel that evaluates mutations in CALR, JAK2 (exons 12–15), and MPL, which are commonly involved in MPNs. Testing these genes is important for identifying MPN types such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF), and for providing a genetic profile to guide diagnosis, treatment, and disease monitoring.

Doctors may recommend this panel if you experience symptoms such as fatigue, weakness, night sweats, or an enlarged spleen, or if you have abnormal blood counts. It is also advised for individuals with a family history of MPNs or known genetic risk factors. This test helps diagnose specific MPNs, differentiate between subtypes for appropriate treatment, monitor therapy response, and assess complication risks.

For this test, it is important to submit the clinical history, histopathology report, previous test results, and a doctor’s prescription at the time of sample collection. The Tata 1mg consolidated Test Requisition Form (TRF) must also be duly filled and submitted.

Lab test results may vary across different laboratories. Abnormal test results require an expert interpretation. Therefore, never try to self-medicate at home based solely on these results, and always consult a doctor for proper understanding of the test results.