
Metanephrine - Free









The Metanephrine - Free test is a blood test that measures the level of free metanephrine in the blood. Metanephrine is formed when the body breaks down epinephrine (adrenaline), one of the hormones involved in the body's stress response. The test may be used to help evaluate suspected pheochromocytoma, It helps doctors detect pheochromocytoma, a rare adrenal gland tumor that causes excess release of these hormones.












Understanding Metanephrine - Free
The Metanephrine - Free test checks for rare tumors called pheochromocytomas and paragangliomas. These tumors can cause the adrenal glands to release too much of the body's stress hormones: epinephrine (adrenaline) and norepinephrine (noradrenaline). When these hormones break down, they form substances called metanephrines. This test measures the level of free metanephrines in the blood.
Doctors may suggest this test if signs of excess adrenaline-like hormone are present or if a tumor like pheochromocytoma is suspected based on symptoms or scan results. It is also used to monitor individuals who have had these tumors in the past. This test can be done if there are symptoms like high blood pressure that comes and goes, a fast heartbeat, headaches, and sweating.
An overnight fast for 8–12 hours is required before the test. However, drinking water is acceptable. Do not consume foods like bananas, pineapples, chocolate, coffee/caffeine, ice cream, vanilla, potatoes, B-complex supplements, high-cereal diets, nicotine/tobacco, and alcohol for at least 48 hours before sample collection. Also, avoid strenuous exercise and stress for at least 24 hours before collection. It is advised to rest quietly by lying down for 20–30 minutes before blood collection.
Do not stop prescribed medicines without your doctor's advice and inform the laboratory and your doctor about all medicines and supplements you are taking. Some medicines can affect results (e.g., certain antidepressants, decongestants/sympathomimetics, amphetamines, labetalol, sotalol). A doctor's prescription is required for the test.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does Metanephrine - Free measure?
The Metanephrine - Free test measures the level of free metanephrine in the blood. Metanephrine is a substance formed when the body breaks down epinephrine (adrenaline). An increased level of metanephrine may be associated with excess catecholamine production and can occur in conditions such as pheochromocytoma. However, elevated levels can also result from certain medicines, physiological stress, or other factors. Therefore, the test result should be interpreted by a doctor in combination with the individual's symptoms, medical history, and other clinical findings. The test may be recommended when pheochromocytoma is suspected or for follow-up evaluation in individuals with a previous history of the condition.





FAQs related to Metanephrine - Free
- Eisenhofer G, Lattke P, Herberg M, Siegert G, Qin N, Därr R, Hoyer J, Villringer A, Prejbisz A, Januszewicz A, Remaley A, Martucci V, Pacak K, Ross HA, Sweep FC, Lenders JW. Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma. Ann Clin Biochem. 2013 Jan;50(Pt 1):62-9. [Accessed 05 Aug. 2025]. Available from:
- Metanephrines (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 05 Aug. 2025]. Available from:
Other tests
- Urine R/M (Urine Routine & Microscopy)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Urine C/S (Urine Culture and Sensitivity),
- Urine C/S (Urine Culture and Sensitivity)
- Serum Creatinine
- LFT and KFT (Liver Function Test & Kidney Function Test)
- LFT and KFT (Liver Function Test & Kidney Function Test),
- Serum Calcium
- Uric Acid, Serum
- Cortisol, Serum (Morning Sample)
- CBC (Complete Blood Count)
- FBS (Fasting Blood Sugar)
- Thyroid Profile Total (T3, T4 & TSH)
- HbA1c (Glycosylated Hemoglobin)
- PPBS (Postprandial Blood Sugar)
- Lipid Profile
- Vitamin D (25-Hydroxy)
- Urine R/M (Urine Routine & Microscopy)
- Coronavirus Covid -19 test- RT PCR
- LFT (Liver Function Test)
- KFT (Kidney Function Test)
- TSH (Thyroid Stimulating Hormone) Ultrasensitive
- ESR (Erythrocyte Sedimentation Rate)
- Uric Acid, Serum
- Vitamin B12
- CRP (C-Reactive Protein), Quantitative
- Urine C/S (Urine Culture and Sensitivity)
- Serum Electrolytes
- Serum Calcium
- Serum Creatinine
- Diabetes Screening (HbA1C & Fasting Sugar)
- KFT with Electrolytes (Kidney Function Test with Electrolytes)
- Cholesterol - Total
- Hb (Hemoglobin)
- Complete Hemogram (CBC & ESR)











