
Metanephrine - Free









The Metanephrine - Free test is a blood test that measures the level of free metanephrine in the blood. Metanephrine is formed when the body breaks down epinephrine (adrenaline), one of the hormones involved in the body's stress response. The test may be used to help evaluate suspected pheochromocytoma, It helps doctors detect pheochromocytoma, a rare adrenal gland tumor that causes excess release of these hormones.












Understanding Metanephrine - Free
The Metanephrine - Free test checks for rare tumors called pheochromocytomas and paragangliomas. These tumors can cause the adrenal glands to release too much of the body's stress hormones: epinephrine (adrenaline) and norepinephrine (noradrenaline). When these hormones break down, they form substances called metanephrines. This test measures the level of free metanephrines in the blood.
Doctors may suggest this test if signs of excess adrenaline-like hormone are present, or if a tumor like pheochromocytoma is suspected based on symptoms or scan results. It is also used to monitor individuals who have had these tumors in the past. This test can be done if there are symptoms like high blood pressure that comes and goes, a fast heartbeat, headaches, and sweating.
An overnight fast for 8–12 hours is required before the test. However, drinking water is acceptable. Avoid taking specific medicines like labetalol, sotalol, acetaminophen, methyldopa, antidepressants, and agents such as ephedrine, amphetamine, nicotine, and caffeine before the test. Foods like bananas, pineapples, nuts, and cereals should also be avoided for at least 72 hours before sample collection.
Always inform the doctor about any medications or supplements being taken, as they may affect the test results.
Test result ranges are approximate and may differ slightly between labs depending on the methodology and laboratory guidelines. Do not self-medicate, and always consult a doctor to understand the test results correctly.
Please note: This is an outsourced test. The sample for this test is collected by TATA 1MG and processed at a NABL accredited partnered lab.
What does Metanephrine - Free measure?
The Metanephrine - Free test measures the level of free metanephrine in the blood. Metanephrine is a substance formed when the body breaks down epinephrine (adrenaline). An increased level of metanephrine may be associated with excess catecholamine production and can occur in conditions such as pheochromocytoma. However, elevated levels can also result from certain medicines, physiological stress, or other factors. Therefore, the test result should be interpreted by a doctor in combination with the individual's symptoms, medical history, and other clinical findings. The test may be recommended when pheochromocytoma is suspected or for follow-up evaluation in individuals with a previous history of the condition.





FAQs related to Metanephrine - Free
- Eisenhofer G, Lattke P, Herberg M, Siegert G, Qin N, Därr R, Hoyer J, Villringer A, Prejbisz A, Januszewicz A, Remaley A, Martucci V, Pacak K, Ross HA, Sweep FC, Lenders JW. Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma. Ann Clin Biochem. 2013 Jan;50(Pt 1):62-9. [Accessed 05 Aug. 2025]. Available from:
- Metanephrines (Blood) [Internet]. Rochester, NY: University of Rochester Medical Center; [Accessed 05 Aug. 2025]. Available from:
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